A5086916644- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Nuclear physics research studies
- Lipid metabolism and biosynthesis
- Fatty Acid Research and Health
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Chromatography in Natural Products
- Cholesterol and Lipid Metabolism
- Muscle Physiology and Disorders
- Quantum Chromodynamics and Particle Interactions
- Medicinal Plant Pharmacodynamics Research
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Particle physics theoretical and experimental studies
- Cancer Treatment and Pharmacology
- Nanoplatforms for cancer theranostics
- Pulsars and Gravitational Waves Research
- Adipokines, Inflammation, and Metabolic Diseases
Jiangnan University
2016-2025
State Key Laboratory of Food Science and Technology
2014-2024
State Grid Corporation of China (China)
2024
Second People’s Hospital of Yibin
2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Chinese University of Hong Kong
2019
Northeast Agricultural University
2013-2017
Fibroblast growth factor 21 (FGF21), a recently identified member of the FGF superfamily, is mainly secreted from liver and adipose tissues plays an important role in improving metabolic syndrome homeostasis. The aim this study to evaluate FGF21 alcoholic fatty disease (AFLD) determine if it has therapeutic effect on AFLD. In paper, we tested alcohol-induced injury murine model chronic ethanol gavage alcohol-treated HepG2 cells. Male KM mice received single dose 5 g/kg every day for 6 weeks,...
Metabolic syndrome (MetS) is closely associated with an increased risk of dementia and cognitive impairment, a complex interaction genetic environmental dietary factors may be implicated. Free fatty acid receptor 4 (Ffar4) bridge the aspects MetS development. However, role Ffar4 in MetS-related dysfunction unclear. In this study, we found that expression down-regulated mice patients impairment. Conventional microglial conditional knockout exacerbated high-fat diet (HFD)–induced anxiety,...
Abstract Background Sarcopenia, the age‐related decline in skeletal muscle mass and function, diminishes life quality elderly people. Improving capacity of differentiation is expected to counteract sarcopenia. However, mechanisms underlying are complex, effective therapeutic targets largely unknown. Methods The human Gene Expression Omnibus database, aged mice primary cells were used assess expression level pyruvate dehydrogenase B (PDHB) mouse state. d ‐Galactose ( ‐gal)‐induced sarcopenia...
Danshen, a well-known traditional Chinese medicine (TCM), has gained increasing attention due to the protective effects on nonalcoholic fatty liver disease (NAFLD). However, molecular basis and working mechanism remain be elucidated. Niemann-Pick C1-like 1 (NPC1L1) is crucial target mediating intestinal cholesterol absorption its inactivation been shown alleviate NAFLD. Thus, this study aimed screen NPC1L1 inhibitors in Danshen investigate therapeutic A high-throughput screening platform...
Newcastle disease virus (NDV) have shown oncolytic therapeutic efficacy in preclinical study and are currently approved for clinical trials. NDV Anhinga strain which is a mesogenic should be classified as lytic has hepatocellular cancer. In this study, we evaluated the capacity of to elicit immune reaction vivo possibility using vaccine vector expressing tumor factors. Interleukin-2 (IL-2) could boost response against cells. Therefore, use backbone construct recombinant (NDV/Anh-IL-2) IL-2....
Due to the complexity and incomplete understanding of crosstalk between liver adipose tissue, especially processes hepatic lipogenesis adipogenic differentiation, there are currently no effective drugs for treatment nonalcoholic fatty disease (NAFLD). Stearoyl-coenzyme A desaturase 1 (SCD1), which is abundantly expressed in may mediate cross-talk tissue. Thus, it essential develop specific SCD1 inhibitors that target liver-adipose axis. Herein, we identified a novel inhibitor, E6446, through...
All-trans retinoic acid (ATRA), one of vitamin A derivatives, shows greater growth inhibition breast cancer cell for ER-positive than ER-negative cells, while triple negative such as MDA-MB-231 is poorly responsive to ATRA treatment. In this study, we found that combination ω-3 free fatty acids (ω-3 FFAs) and exhibited synergistic in three subtypes (ER
Inflammatory bowel disease (IBD) has complex genetic and environmental aspects, free fatty acid receptors (FFARs) may bridge dietary aspects. FFAR4 is highly expressed in the intestine acts primarily as receptor of long-chain acids, which are major components human diet. It unclear what role, if any, play IBD.Mouse colitis samples, mice with complete knockout, intestine-specific knockout overexpression cell culture were used. RNA-sequencing analysis flow cytometry performed to examine...
Castration-resistance of prostate cancer is one the most challenging clinical problems. In present study, we have performed proteomics and glycomics using LNCaP model. Growth differentiation factor-15 (GDF15) level increased in androgen receptor (AR) inhibitor-resistant cells inhibitory effect GDF15 on epithelial growth factor (EGFR) pathway relieved by N70 glycosylation. Interference (siRNA or N70Q dominant negative) EGFR (inhibitor siRNA for EGFR, SRC ERK) decreases resistant-cell survival...
The gut-liver axis plays a key role in the development and progression of non-alcoholic fatty liver disease (NAFLD). Due to complexity incomplete understanding cross-talk between gut liver, effective therapeutic targets are largely unknown. Free acid receptors (FFARs) may bridge liver. FFAR4 has received considerable attention due its important lipid metabolism. However, this cross talk NAFLD remains unclear. In study, mice with high endogenous n-3 PUFAs but deficiency were generated by...
Abstract Background The incidence of diabetic kidney disease (DKD) continues to rapidly increase, with limited available treatment options. One the hallmarks DKD is persistent inflammation, but underlying molecular mechanisms early injury remain poorly understood. C-X-C chemokine receptor 2 (CXCR2), plays an important role in progression inflammation-related vascular diseases and may bridge between glomerular endothelium inflammation DKD. Methods Multiple methods were employed assess...
Breast cancer is a leading type of in women and generally classified into three subtypes ER+ /PR+ , HER2+ triple negative. Both omega-3 polyunsaturated fatty acids vitamin D3 play positive role the reduction breast incidence. However, whether combination has stronger protective effect on carcinogenesis still remains unknown. In this study, we show that ω-3 free (ω-3 FFAs) 1α, 25-dihydroxy-vitamin (VD3 ) dramatically enhances cell apoptosis among lines. Bcl-2 total PARP protein levels are...
Abstract T‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in progression toxin‐stimulated injury. A metabolomics experiment is performed to assess responses infection human podocytes. Roles protein O‐linked‐N‐acetylglucosaminylation (O‐GlcNAcylation) regulating injury mouse models are assessed. O‐GlcNAc target proteins recognized by mass spectrometry...