A5101784529- Acute Kidney Injury Research
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Antibiotic Resistance in Bacteria
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Genomics and Phylogenetic Studies
- Virus-based gene therapy research
- Metal and Thin Film Mechanics
- Bacterial biofilms and quorum sensing
- Acute Myocardial Infarction Research
- Silicone and Siloxane Chemistry
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Cardiac and Coronary Surgery Techniques
- Marine Biology and Environmental Chemistry
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Congenital Diaphragmatic Hernia Studies
- Atrial Fibrillation Management and Outcomes
- Neurogenesis and neuroplasticity mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Cardiac Ischemia and Reperfusion
Xiangya Hospital Central South University
2023-2025
Central South University
2023-2025
Inner Mongolia University of Science and Technology
2024
Baotou Medical College
2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Bengbu Medical College
2023-2024
Anhui Agricultural University
2024
Jiangsu University
2024
This study investigated whether exosomes from LPS pretreated bone marrow mesenchymal stem cells (LPS pre-MSCs) could prolong skin graft survival.The were isolated the supernatant of MSCs with LPS. pre-Exo and rapamycin injected via tail vein into C57BL/6 mice allografted BALB/c skin; survival was observed evaluated. The accumulation polarization macrophages examined by immunohistochemistry. differentiation in spleen analyzed flow cytometry. For vitro, an inflammatory model established....
ABSTRACT The purpose of this study is to reveal the expression profile microRNA (miRNA) in plasma exosomes patients with alcohol‐induced osteonecrosis femoral head (AIONFH), and further explore potential effect alcohol‐stimulated hepatocyte on vascular endothelial cells (VECs). total RNA normal people (NC‐Exos) AIONFH (AI‐Exos) were extracted, followed by Illumina high‐throughput sequencing. GO KEGG analyses performed. MiR‐155‐5p (AML‐Exos) was detected RT‐PCR. effects AI‐Exos/AML‐Exos...
Abstract Background The ischemia–reperfusion (IR) environment during deep hypothermic circulatory arrest (DHCA) cardiovascular surgery is a major cause of acute kidney injury (AKI), which lacks preventive measure and treatment. It was reported that cold inducible RNA-binding protein (CIRP) can be induced under hypoxic stress may have protective effect on multiple organs. purpose this study to investigate whether CIRP could exert renoprotective IR the potential mechanisms. Methods Utilizing...
Evidence on the association between long-term ozone exposure and greenness hemorrhagic stroke (HS) is limited, with mixed results. One potential source of this inconsistency difference in time metrics. This study aimed to investigate ambient ozone, greenness, mortality from HS using metrics at different times. We also examined whether modified relationship due HS. The population consisted 45771 participants aged ≥40 y residing 20 counties Shandong Province who were followed up 2013 2019....
Delftia tsuruhatensis has become an emerging pathogen in humans. There is scant information on the genomic characteristics of this microorganism. In study, we determined complete genome sequence a clinical D. strain, TR1180, isolated from sputum specimen female patient China 2019. Phylogenetic and average nucleotide identity analysis demonstrated that TR1180 member . exhibited resistance to β-lactam, aminoglycoside, tetracycline sulphonamide antibiotics, but was susceptible phenicols,...
Mortality and morbidity of children received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support after cardiac surgery remain high despite remarkable advances in medical management devices. The purpose this study was to describe outcomes risk factors applying VA-ECMO the surgical pediatric population. We retrospectively analyzed 85 consecutive patients (aged <18 years) who postcardiotomy from January 2010 December 2018. Median (IQR) age at ECMO implantation cohort 12.7 (6.4,...
Abstract Introduction: Observational studies have revealed an association between waist circumference (WC) and atrial fibrillation (AF). However, it is difficult to infer a causal relationship from observational because the observed associations could be confounded by unknown risk factors. Therefore, role of WC in AF unclear. This study was designed investigate using two-sample Mendelian randomization (MR) analysis. Methods: In our MR analysis, genetic variation used as instrumental variable...
Total cavopulmonary connection (TCPC) is a definitive palliative procedure for functionally univentricular congenital heart disease. The study aims to compare the impact of on-pump cardioplegic arrest and beating cardiopulmonary bypass (CPB) on prognosis pediatric patients undergoing extracardiac TCPC.
Neutrophil-lymphocyte ratio (NLR) is a valuable indicator for evaluating inflammation and adverse outcomes after cardiac surgery. The objective of this study was to evaluate the association perioperative NLR with clinical in infants undergoing congenital heart surgery cardiopulmonary bypass.
Multidrug-resistant bacteria from different sources have been steadily emerging, and an increasing number of resistance mechanisms are being uncovered. In this work, we characterized a novel gene named aac(2')-If isolate Providencia species, wenzhouensis R33 (CCTCC AB 2021339). Susceptibility testing enzyme kinetic parameter analysis were conducted to determine the function aminoglycoside 2'-N-acetyltransferase. Whole-genome sequencing comparative genomic performed elucidate molecular...
Abstract Background KDIGO and pRIFLE classifications are commonly used in pediatric acute kidney injury (AKI). As a novel AKI definition, pROCK considered the high variability of serum creatinine children. This study aimed to compare above three definitions for infants undergoing cardiac surgery. Methods We analyzed clinical cohort 413 was defined staged according pRIFLE, KDIGO, pROCK, respectively. Incidence differences diagnostic agreement across were assessed. The association between...
This study sought to determine pulmonary vascular volumes (PVVs) on low-dose computed tomography (LDCT) in a healthy male Chinese population and analyze the effects of aging smoking PVVs.A total 1,320 participants (comprising 720 non-smokers, 445 smokers, 155 ex-smokers) who underwent LDCT were retrospectively included this study. Their demographic data status collected. An automatic integration segmentation approach for was used segment vessels semi-automatically. The PVVs whole lung, left...
Background Pediatric postcardiotomy veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients have high mortality and morbidity. There are currently three scoring systems available to predict mortality: the Extracorporeal Membrane Oxygenation Prediction (PEP) model, Precannulation Survival After VA-ECMO (Pedi-SAVE) score, Postcannulation Pedi-SAVE score. These methods provide risk stratification scores for pediatric requiring ECMO cardiac support. However, comparative validation...
Heparin resistance (HR) is a common finding in pediatric cardiac surgery and generally refers to decreased sensitivity heparin. Antithrombin (AT) deficiency considered the primary mechanism of HR; however, etiology HR may be multifactorial. Early identification might help optimize heparin anticoagulation management. This study aimed develop predictive nomogram for neonates young infants undergoing surgery.
Iron deficiency (ID) is common in patients undergoing cardiac surgery, which associated with adverse outcomes. However, the relevance of ID congenital heart disease still unclear. This study aimed to investigate characteristics preoperative and its association clinical outcomes infants surgery cardiopulmonary bypass.In this retrospective study, 314 were assigned into three groups according their status. Absolute was defined by serum ferritin <12 μg/L, functional level at 12-30 μg/L...
The association of high-sensitivity C-reactive protein (hsCRP) and anemia with postoperative acute kidney injury (AKI) in neonates congenital heart disease (CHD) is still unclear. purpose this study was to examine whether anemia-associated AKI modulated by hsCRP neonates. This included 253 consecutive neonatal patients who underwent CHD surgery a national tertiary hospital. We investigated the between baseline hsCRP, anemia, their interaction multivariable logistic regression analyses....