A5067682918- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Wound Healing and Treatments
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Oral Health Pathology and Treatment
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Nanoparticle-Based Drug Delivery
- Systemic Sclerosis and Related Diseases
- Reconstructive Surgery and Microvascular Techniques
- Ferroptosis and cancer prognosis
- Eosinophilic Esophagitis
- Inflammation biomarkers and pathways
- Adenosine and Purinergic Signaling
- Lymphatic System and Diseases
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Apelin-related biomedical research
Central South University
2019-2025
Xiangya Hospital Central South University
2022-2024
First Hospital of Jilin University
2023
Jilin University
2023
BackgroundPerforator flaps are widely used in hand microsurgery to reconstruct and repair soft tissue injuries. However, ischemia subsequent ischemia-reperfusion injury may cause distal necrosis of the flap. Itaconic acid (IA) is a modulator macrophage function, which exerts anti-inflammatory effects activation.MethodsThe necrotic area flap was detected by measuring temperature with an infrared thermometer. Flap cell apoptosis TUNEL staining Western blot analysis apoptosis-associated...
This study investigated whether exosomes from LPS pretreated bone marrow mesenchymal stem cells (LPS pre-MSCs) could prolong skin graft survival.The were isolated the supernatant of MSCs with LPS. pre-Exo and rapamycin injected via tail vein into C57BL/6 mice allografted BALB/c skin; survival was observed evaluated. The accumulation polarization macrophages examined by immunohistochemistry. differentiation in spleen analyzed flow cytometry. For vitro, an inflammatory model established....
Secondary lymphedema often occurs after filariasis, trauma, lymph node dissection and radiation therapy, which is manifested by infiltration of inflammatory cells fibrosis formation in pathologically. Substance P a widely used neuropeptide the field tissue repair, while regenerative potential substance has not been proven secondary lymphedema. In this study, animal model was constructed excising skin subcutaneous lymphatic network tail mice, degree swelling mice evaluated 6 weeks under...
Abstract Objectives Mesenchymal stem cells (MSCs) could regulate the function of various immune cells. It remains unclear whether MSCs additionally possess immunostimulatory properties. We investigated impact human on responsiveness primary natural killer (NK) in terms induction anti‐inflammatory purinergic signalling. Material and Methods obtained bone marrow mesenchymal (BMMSCs) dental pulp (DPSCs). NK were isolated from peripheral blood healthy volunteers. Activated cultured with MSCs....
Peripheral nerve adhesion occurs following injury and surgery. Functional impairment leading by peripheral remains challenging for surgeons. Local tissue overexpression of heat shock protein (HSP) 72 can reduce the occurrence adhesion. This study aims to develop a photothermal material polydopamine nanoparticles@Hyaluronic acid methacryloyl hydrogel (PDA NPs@HAMA) evaluate their efficacy preventing in rat sciatic model.PDA NPs@HAMA was prepared characterized. The safety PDA evaluated....
Head and neck squamous cell carcinoma (HNSCC) remains an unmet medical challenge. Metabolic reprogramming is a hallmark of diverse cancers, including HNSCC.We investigated the metabolic profile in HNSCC by using The Cancer Genome Atlas (TCGA) (n = 481) Gene Expression Omnibus (GEO) 97) databases. stratification samples was identified unsupervised k-means clustering. We analyzed correlations subtypes with featured genomic alterations known subtypes. further validated metabolism-related based...
Oral submucous fibrosis (OSF) is a potentially malignant disorder characterized by the accumulation of extracellular matrix in oral mucosa, which leads to stiffening and can result trismus. There still lack effective measures prevent treat OSF. Nitrate has been verified provide protective responses against fibrotic diseases multiple organs tissues. It remains unclear whether dietary nitrate In present study, we established OSF rat model evaluate effect for preventing treatment demonstrated...
Traditional observational studies have shown that fatty acids and gut microbiota are crucial in osteoarthritis (OA) progression, but their findings often conflicting due to biases, confounding factors, measurement errors. We conducted a two-sample Mendelian randomization analysis using genome-wide association study data on from 136,016 individuals, the 7738 314,870 individuals. Elevated levels of total (odds ratio [OR]: 0.92; 95% CI 0.84–1.00; P = .039), saturated (OR: 0.91; 0.84–0.99;...
Background: Head and neck squamous cell carcinoma's tumor immune microenvironment (TIME) plays an important role in tumorigenesis progression, but its clinical significance remains unclear. Therefore, the TIME needs to be better understood order improve response of diagnosis therapy. Methods: The gene expression data 569 HNSCC patients were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). Immune-related genes (IRGs) ImmPort database used for immunotyping patients,...
Abstract Peripheral nerve regeneration is a complex process that involves many signaling pathways, and M2 macrophage polarization was recognized to play pivotal role in this process. The neuroprotective effects of metformin have attracted wide attention, but few reports focusedon the potentialeffects metforminin immunomodulatory properties improve peripheral by affecting polarization. In study, rat model sciatic injury an inflammatory bone marrow-derived (BMDM) cells were established examine...
Abstract Objectives This study investigated whether exosomes from LPS pretreated bone marrow mesenchymal stem cells (LPS pre-MSCs) could prolong skin graft survival. Methods The were isolated the supernatant of MSCs with LPS. pre-Exo and rapamycin injected via tail vein into C57BL/6 mice allografted BALB/c skin; survival was observed evaluated. accumulation polarization macrophages examined by immunohistochemistry. differentiation in spleen analyzed flow cytometry. For vitro, an inflammatory...