A5057477912- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Scoliosis diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Inflammasome and immune disorders
- Adenosine and Purinergic Signaling
- Spinal Hematomas and Complications
- Spinal Cord Injury Research
- Cardiovascular Issues in Pregnancy
- Anesthesia and Pain Management
- Magnesium Alloys: Properties and Applications
- Healthcare and Venom Research
- Pelvic and Acetabular Injuries
- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Heterotopic Ossification and Related Conditions
- Biomarkers in Disease Mechanisms
- Cancer-related molecular mechanisms research
- Bone and Joint Diseases
- Foot and Ankle Surgery
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Pulmonary Hypertension Research and Treatments
Huashan Hospital
2016-2025
Fudan University
2016-2025
Orthopedic One
2016
National Natural Science Foundation of China
2014-2015
Abstract Neuroinflammation plays a crucial role in the secondary phase of spinal cord injury (SCI), and is initiated following activation toll-like receptor 4 (TLR4). However, downstream mechanism remains unknown. Pyroptosis form inflammatory programmed cell death, which closely involved neuroinflammation, it can be regulated by TLR4 according to recent research. In addition, several studies have shown that long non-coding RNAs (lncRNAs) based mechanisms were related signal transduction...
Abstract Intervertebral disc degeneration (IVDD) is the primary cause of low back pain, with oxidative stress being a recognized factor that causes its development. Presently, pain imposes significant global economic burden. However, effectiveness treatments for IVDD remains extremely limited. Therefore, this study aims to explore innovative and effective by focusing on as starting point. In study, an injectable reactive oxygen species‐responsive hydrogel (PVA‐tsPBA@SLC7A11 modRNA)...
Immune activation, specifically activation of macrophages and resident microglia, leading to inflammation is a key component in the progression spinal cord injury (SCI). Macrophages/microglia exist two states-the classically activated M1 phenotype that confers pro-inflammatory effects or alternatively M2 anti-inflammatory effects. Ecto-5'-nucleotidase (CD73) an immunosuppressive molecule intricately involved adaptive innate immune responses able dephosphorylate AMP adenosine. However, it not...
Study Design. Experimental in vivo and vitro study of intervertebral disc (IVD) degeneration the mechanism exploration. Objective. This report aims to verify expression Sirt1 IVD different grades explore its potential human nucleus pulposus cells. Summary Background Data. Silent mating type information regulator 2 homolog 1 (Sirt1) has draw immense attention because influence on a variety aging-related diseases. The present is continuation complement our former role puncture-induced rodent...
To establish a clinician-led guideline for the diagnosis and treatment of Hirayama disease (HD) using modified Delphi technique.Based on combination systematic review opinion ten experts, protocol consensus diagnosis, follow-up assessment HD was established. A 3-round survey then performed by more than 40 panelists from various countries world. Both levels evidence agreement were derived in all statements finial guideline.A total 47 experts 6 enrolled expert panel this study. Highly...
Hirayama disease (HD), amyotrophic lateral sclerosis (ALS) or cervical spondylotic amyotrophy (CSA) may result in atrophy of intrinsic hand and forearm muscles. The incidence HD is low, it rarely encountered the clinical setting. Consequently, often misdiagnosed as ALS CSA. It important to differentiate these diseases because caused by a benign focal lesion that limited upper limbs. thenar hypothenar compound muscle action potential (CMAP) amplitude limbs 100 HD, 97 32 CSA cases were...
Because Hirayama disease is stereotyped as a self-limited in the absence of definite pathology, we investigated potential relationship between snake-eyes appearance (SEA) and to bring new perspective pathological process based on relevant radiological clinical evidence.A total 30 cases observed SEA were selected from 293 patients with constitute group, an equal number randomly remaining form non-SEA group. Cervical magnetic resonance imaging (MRI) was performed subsequently used measure...
Selecting an interbody cage with appropriate height is one of the key steps in lumbar fusion, and has important impact on clinical efficacy. How to choose becomes core problems fusion for spine surgeons. However, studies about objective selection criteria was rare. One hundred fifty-seven patients single segment degenerative diseases treated by TLIF surgery from January 2011 July 2013 were retrospectively analyzed. Parameters analyzed included: gender, age, body height, diagnosis,...
Study Design: A retrospective analysis.Purpose: To investigate the occurrence of central sensitization (CS) in patients with osteoporotic vertebral compression fractures (OVCFs) and identify association between CS residual back pain (RBP).Overview Literature: RBP is a vexing complication that affects 6.3%–17.0% OVCFs who underwent percutaneous vertebroplasty (PVP). Given negative effect on patients’ psychological physiological statuses, efforts to preoperatively select are at risk for...
Abstract Mitochondrial homeostasis plays a crucial role in degenerative joint diseases, including cartilaginous endplate (CEP) degeneration. To date, research into mitochondrial dynamics IVDD is at an early stage. Since Piezo1 novel Ca 2+ ‐permeable channel, we asked whether could modulate fission through signalling during CEP In vitro and vivo models of inflammation‐induced degeneration were established with lipopolysaccharide (LPS). We found increased expression degenerated tissues...
Circular RNAs (circRNAs) are relatively recently identified noncoding that ubiquitously expressed in human tissues and serve key functions regulating gene expression. However, few studies have focused on intervertebral disc degeneration (IDD) circRNAs, the potential role of circRNAs IDD has not been described detail. In present study, circRNA expression data was downloaded from Gene Expression Omnibus database, were classified according to their length, indicating uniform distribution...
Magnesium (Mg) released from Mg-based implants degradation is believed to be effective in improving osteogenesis, however, studies focusing on interbody cages are limited and fusion success was never reported. As excessive Mg accumulation can inhibit new bone formation, this study designed explain the possible reasons for failure of by analyzing relationships between intervertebral resulting fusion. The experimental cage consisted magnesium alloy (AZ31) substrate Silicon (Si) -containing...
Purpose: To compare repetitive nerve stimulation (RNS) between Hirayama disease (HD) and amyotrophic lateral sclerosis (ALS). Methods: The 3-Hz RNS test was performed on bilateral abductor pollicis brevis, digiti minimi, middle deltoid, upper trapezius muscles in 33 HD patients 37 ALS patients. Results: In patients, none of tested showed any abnormal decrements (≥10%). Significant were observed 73% the more frequently proximal (deltoid: 70.3%; trapezius: 48.6%). Illness duration did not...
Endplate pathology plays an important role in the development of lumbar disc degeneration. Previous research paid little attention to differences between superior and inferior endplates as a possible risk factor for The purpose this study was test hypothesis that asymmetry is A total 134 patients with herniation (LDH) 100 healthy adults ("Controls") underwent magnetic resonance imaging scans. Each categorized non-degenerated (Pfirrmann grades I-II) or degenerated III-V) get following three...
Spinal gout is rare in patients younger than 45 years, occurring most commonly between ages and 80 years. This article describes a 29-year-old man with history of initially observed more 20 years previously who presented lower back pain left limb weakness. Computed tomography magnetic resonance imaging revealed severely damaged facet joints laminae surrounding L4-S1, materials granular, yellow, cheese-like appearance were under direct vision. Postoperative histological examination confirmed...
Bioabsorbable Mg-based implants were previously assessed due to their intrinsic advantages, but cage related research is limited. The specific blood supply and stress of the intervertebral environment can affect function implants. objective this study was investigate performance a bioabsorbable Mg-Zn alloy in anterior cervical discectomy fusion (ACDF) evaluate control degradation surface modified by microarc oxidation (MAO) technology containing Si under an microenvironment.Twenty-four goats...
Objective. To evaluate the forward shifting of cervical spinal cords in different segments patients with Hirayama disease to determine whether is self-limiting. Methods. This study was performed on 11 healthy subjects and 64 patients. According duration, were divided into 5 groups (≤1 year, 1-2 years, 2-3 3-4 ≥4 years). Cervical magnetic resonance imaging (MRI) flexion conventional position performed. The distances between posterior edge cord canal (<mml:math...
We report two rare cases of spinal intraosseous schwannoma (SIS) with sustained myelopathy symptoms and provide an updated review regarding SIS in the literature. A 71-year-old man experienced right lumbocrural pain gait disturbance accompanied paresthesia leg weakness. Imaging examinations revealed a mass lesions L4 vertebral body causing bone destruction cord compression. Complete resection well-demarcated tumor posterior fusion were performed. 54-year-old female reported bilateral...
A retrospective clinical data analysis.To investigate the factors related to postoperative neurological deficits after nerve root resection in treatment of spinal intradural schwannoma.Neurological could be observed tumor-involved roots schwannoma. Thus, it is important find deficits.Clinical and pathological were selected from patients underwent total solitary schwannoma T11 S. Patients divided into positive group (PND group, n = 12) negative (non-PND 52). Clinical features including age,...