A5101873999- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- T-cell and B-cell Immunology
- Salivary Gland Disorders and Functions
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Biosimilars and Bioanalytical Methods
- Orthopedic Infections and Treatments
- Cell Adhesion Molecules Research
- HIV Research and Treatment
- Chemokine receptors and signaling
- Inflammasome and immune disorders
- Inflammatory Bowel Disease
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Inflammatory Myopathies and Dermatomyositis
- Cancer Immunotherapy and Biomarkers
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood groups and transfusion
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal Tumor Research and Treatment
- Otitis Media and Relapsing Polychondritis
Shanxi Medical University
2019-2022
Second Hospital of Shanxi Medical University
2019-2022
Objective To guide clinical decision making, race-, age- and gender-specific reference ranges for lymphocytes CD4+ T-cell subsets are required. Methods Single platform flow cytometry to determine intervals lymphocyte subpopulations in 196 healthy Han Chinese adults. Results The frequencies absolute numbers of B cells were slightly lower individuals the Shanxi region than from Hong Kong, Germany Singapore, while percentages NK higher compared with Kong. CD4+/CD8+ ratios, T cell Th2 counts...
Distinguishing flares from bacterial infections in systemic lupus erythematosus (SLE) patients remains a challenge. This study aimed to build model, using multiple blood cells and plasma indicators, improve the identification of SLE.Building PLS-DA/OPLS-DA models bioscore system distinguish SLE.Department Rheumatology Second Hospital Shanxi Medical University.SLE with (n = 142) or 106) were recruited this retrospective study.The peripheral these was collected by experimenter measure levels...
<h3>Background:</h3> Some of the autoantibodies found in RA are primarily directed against these citrullinated protein epitopes and can be even before symptoms arthritis appear <sup>[1]</sup>. So detection antibodies used clinical practice to help develop therapeutic strategies. The classic method for detecting anti-CCP serum is ELISA. However, traditional ELISA still has some inevitable limitations, such as time-consuming, complicated process low degree automation, may not able provide...
Background: Little known about the roles of peripheral immune cell subsets in IgG4-related disease (IgG4-RD). Objectives: The aim our study was to analyze role low-dose interleukin-2 (ld-IL2) on these cells IgG4-RD. Methods: percentage and absolute counts lymphocyte subpopulations [CD3+ (T cells), CD4+, CD8+, CD19+ (B cells) CD16+CD56+ (NK cells)] CD4+T (Th1, Th2, Th17, regulatory T (Treg)) using single platform flow cytometry 25 IgG4-RD patients which were admitted treated, as well 24...
<h3>Background</h3> Interferons (IFNs) have long been implicated in the pathogenesis of systemic lupus erythematosus (SLE). However, specific consequences IFN activity not well-defined. In this study, biology associated with an signature was assessed SLE blood neutrophil and PBMC fractions. <h3>Objectives</h3> We alterations transcriptome isolated PBMCs neutrophils dysregulation (IFN high vs. low), used data to describe activation differences between cell types. <h3>Methods</h3> RNA...
Detection of autoantibody against extractable nuclear antigens (ENAs) plays a critical role in the diagnosis and management autoimmune diseases.In this study, we assessed performance LETIA detecting anti-ENAs. Total 606 serum samples from Second Hospital Shanxi Medical University were collected. Anti-SSA, anti-SSB, anti-Sm, anti-U1-snRNP, anti-Sm/RNP parallelly detected by line immunoblot (LIA). Besides, study for its repeatability anti-ENAs autoantibodies, consistency with LIA. A receiver...