A5101404175- Drug-Induced Hepatotoxicity and Protection
- Inflammasome and immune disorders
- Nerve injury and regeneration
- Liver physiology and pathology
- Silymarin and Mushroom Poisoning
- Drug Transport and Resistance Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral gastroenteritis research and epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Gout, Hyperuricemia, Uric Acid
- Hepatitis Viruses Studies and Epidemiology
- Pharmacological Effects of Natural Compounds
- Axon Guidance and Neuronal Signaling
- Pharmacogenetics and Drug Metabolism
- Natural product bioactivities and synthesis
- Cyclopropane Reaction Mechanisms
- Extracellular vesicles in disease
- Wnt/β-catenin signaling in development and cancer
- Virus-based gene therapy research
- Biomarkers in Disease Mechanisms
- Synthesis and Reactivity of Heterocycles
Taiwan Semiconductor Manufacturing Company (China)
2022-2024
Nanjing Medical University
2024
Huaian First People’s Hospital
2024
Nanjing Drum Tower Hospital
2021-2023
China Pharmaceutical University
2012-2021
Huazhong University of Science and Technology
2016-2021
State Key Laboratory of Natural Medicine
2021
Heilongjiang University of Chinese Medicine
2017-2021
Union Hospital
2021
Chongqing Medical University
2010-2020
Silybin is one of the effective, traditional Chinese medicines used as a hepatoprotective agent in nonalcoholic fatty liver disease (NAFLD) therapy worldwide, and NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has been recognized an important factor involved NAFLD development. However, little known about mechanisms silybin regulation high-fat diet (HFD)–induced inflammation. In our study, we found that inhibited endoplasmic reticulum stress NLRP3 activation livers...
Silybin shows good effects against obesity and metabolic syndrome, but the systemic modulation effect of silybin has not been fully revealed. This study aims to investigate regulation by nonalcoholic fatty liver disease (NAFLD). C57BL/6 J mice were fed a high-fat/high-cholesterol diet for 8 weeks treated with (50 or 100 mg/kg/day) sodium tauroursodeoxycholate (TUDCA, 50 gavage last 4 weeks. Blood biochemical indexes hepatic lipid measurement as well Oil red O staining conducted evaluate...
Due to the substantial interspecies differences in drug metabolism and disposition, drug-induced liver injury (DILI) humans is often not predicted by studies performed animal species. For example, a (bosentan) used treat pulmonary artery hypertension caused unexpected cholestatic toxicity humans, which was preclinical toxicology multiple In this study, we demonstrate that NOG mice expressing thymidine kinase transgene (TK-NOG) with humanized livers have profile of biliary excretion test...
We have developed a DNA origami-based platform for detecting aflatoxin B1 the first time with assistance of aptamer probes and its complementary ssDNA-modified gold nanoparticles.
Abstract Background: Acute lung injury (ALI) is a respiratory disease with high morbidity and mortality rates. Currently, there no effective treatment to complement mechanical ventilation. Exosomes microRNAs (miRNAs) are promising agents for the management of this disease. Methods: were isolated from mouse bone marrow stromal stem cells (BMSCs). The levels two miRNAs, miR-542-3P miR-150, in exosomes determined using RT-PCR, miR-150 was selected further study. ALI model established mice...
The pharmacopoeias list a number of microorganisms to be used in the compendial microbiological tests for confirming growth-promoting, indicative, and inhibitory properties media demonstrating suitability test specific article. Major national culture collections are specified as sources these strains based on their history deposition maintenance use tests. Using microorganisms, it has long been assumed that interchangeable sourcing from different no impact result quality control method...
Abstract Drug-induced liver injury (DILI) is the leading cause of acute failure (ALF). Continuous and prolonged hepatic cellular oxidative stress inflammatory stimuli are key signatures DILI. DEAD-box helicase 3, X-linked (DDX3X) a central regulator in pro-survival granule (SG) assembly response to signals. However, role DDX3X DILI remains unknown. Herein, we characterized hepatocyte-specific Human tissues patients control subjects were used evaluate expression. APAP, CCl4 TAA models...
A possible mechanism involving transmembrane release of O<sub>2</sub><sup>−</sup>was revealed to explain nanosilver-caused suppression aflatoxin production from<italic>Aspergillus flavus</italic>.
Caulophyllum robustum Maxim (CRM) is a Chinese folk medicine with significant effect on treatment of rheumatoid arthritis (RA). This study was designed to explore the spectrum-effect relationships between high-performance liquid chromatography (HPLC) fingerprints and anti-inflammatory effects CRM. Seventeen common peaks were detected by fingerprint similarity evaluation software. Among them, 15 identified Liquid Chromatography-Mass Spectrometry (LC-MS). Pharmacodynamics experiments conducted...
Abstract Tumor angiogenesis is mediated by vascular endothelial growth factor receptor (VEGFR) and other protein kinases. Inhibition of these kinases presents an attractive approach for developing anticancer therapeutics. In this work, a series 2,5,7‐trisubstituted oxazolo[5,4‐ d ]pyrimidines were synthesized, their inhibitory activities investigated against VEGFR‐2 human umbilical vein cells (HUVEC) in vitro. Compound 9n exhibited the most potent activity with IC 50 values 0.33 0.29 μ M...
Proteolysis targeting chimera (PROTAC) is a protein degradation technique that has been increasingly used in the development of new drugs recent years. Akt classical serine/threonine kinase, and its role outside kinase gradually gained attention years, making it one proteins targeted by PROTACs. Currently, there are many methods for evaluation intracellular degradation, but each own advantages or disadvantages. This study aimed to investigate feasibility evaluating pan-Akt cells PROTACs...
Interspecies differences have limited the predictive utility of toxicology studies performed using animal species. A drug that could be a safe and effective treatment in humans cause toxicity animals, preventing it from being used humans. We investigated whether use thymidine kinase (TK)–NOG mice with humanized livers prevent this unfortunate outcome (i.e., "rescue" for humans). high dose furosemide is known to severe liver mice, but demonstrate administration (200 mg/kg i.p.) causes...
In adult mammals, CNS damage does not repair well spontaneously. The Nogo receptor (NgR) signaling pathway prevents axonal regrowth and promotes neuronal apoptosis. This pathway, pathways like it, may be part of the reason why nerves do regrow. A number preclinical experiments inhibiting portions NgR have yielded limited induction nerve repair. Here, we developed a small hairpin RNA (shRNA) to knock down expression. With use rat hippocampal slices in tissue culture, induced similar that...