A5057922694- Immune Cell Function and Interaction
- Bacterial Infections and Vaccines
- Thyroid and Parathyroid Surgery
- Pneumonia and Respiratory Infections
- Myasthenia Gravis and Thymoma
- Respiratory viral infections research
- Thyroid Cancer Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Neuroscience and Neuropharmacology Research
- Diabetes and associated disorders
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Pituitary Gland Disorders and Treatments
- Ear Surgery and Otitis Media
- Neurotransmitter Receptor Influence on Behavior
- Cardiac Valve Diseases and Treatments
- Voice and Speech Disorders
- Liver physiology and pathology
- RNA Interference and Gene Delivery
- Airway Management and Intubation Techniques
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- Surgical Sutures and Adhesives
- Nutrition and Health in Aging
- Lung Cancer Research Studies
Wakayama Medical University
2015-2025
Stanford University
2004-2024
Stanford Medicine
2022-2023
Osaka University
1980-2019
Eli Lilly (United States)
2014
Bruker (United States)
2014
Central Institute for Experimental Animals
2014
Meijo University
2012
Prefectural University of Hiroshima
2011
Infiltration of natural killer (NK) cells into solid organ allografts is observed in clinical and experimental transplantation. Studies suggest a role for NK acute chronic rejection allografts; however, the effects immunosuppressive agents on are not clearly established. Rat cell lines were analyzed proliferation cytotoxicity presence cyclosporine, FK506, or rapamycin. Lewis recipients DA liver received after demonstrated robust function both absence cyclosporine FK506. In contrast,...
Due to the substantial interspecies differences in drug metabolism and disposition, drug-induced liver injury (DILI) humans is often not predicted by studies performed animal species. For example, a (bosentan) used treat pulmonary artery hypertension caused unexpected cholestatic toxicity humans, which was preclinical toxicology multiple In this study, we demonstrate that NOG mice expressing thymidine kinase transgene (TK-NOG) with humanized livers have profile of biliary excretion test...
Pneumococcal conjugated vaccine (PCV) has contributed to a dramatic reduction in invasive pneumococcal diseases. However, its impact upon nasopharyngeal carriage and upper respiratory tract infections is unclear. This study was aimed evaluate the humoral immunity against Streptococcus pneumoniae children with recurrent acute otitis media (rAOM) post PCV era. We evaluated eight representative serotypes included PCV13 (3, 6 A, 6B, 9 V, 14, 18 C, 19 F, 23 F) among rAOM. Serum total...
Hamartomas are classified as either epithelial, mesenchymal, or epithelium-mesenchymal mixed types. They occur extremely rarely in the nasopharynx. A 58-year-old man had multiple tumors with repeating contraction and relaxation nasopharynx shown on endoscopy. One of was endoscopically resected under general anesthesia for histological examination finally diagnosed mesenchymal hamartoma. Smooth muscle tissue is sometimes confirmed hamartomas, but spontaneous nasopharyngeal hamartomas rare. In...
We established an infant mouse model for colonization and transmission by nonencapsulated Streptococcus pneumoniae (NESp) strains to gain important information about its virulence among children. Invasive pneumococcal diseases have decreased dramatically since the worldwide introduction of capsular polysaccharide vaccines. Increasing prevalence nonvaccine serotypes, including NESp, has been highlighted as a challenge in treatment strategy, but NESp is not well understood. Protective...
Interspecies differences have limited the predictive utility of toxicology studies performed using animal species. A drug that could be a safe and effective treatment in humans cause toxicity animals, preventing it from being used humans. We investigated whether use thymidine kinase (TK)–NOG mice with humanized livers prevent this unfortunate outcome (i.e., "rescue" for humans). high dose furosemide is known to severe liver mice, but demonstrate administration (200 mg/kg i.p.) causes...
A nonrecurrent laryngeal nerve (NRLN) is a rare anatomical variant of nerves that branches directly from the vagus nerve. The abnormality makes it difficult to identify NRLN and results in high incidence accidental injury during surgery. 76-year-old woman complained swelling right side her neck visited our university hospital for further examination. Ultrasonography showed thyroid lobe mass with calcification fine needle aspiration biopsy was classified as class III. Computed tomography...
Thyroid carcinoma showing thymus-like differentiation (CASTLE) is thought to originate from ectopic thymic tissue or remnants of the developing thymus within adjacent thyroid. This case report describes a mass located on left thyroid 28-year-old man. Fine-needle aspiration cytology revealed number lymphoid cells without atypia that were similar those seen in malignant lymphoma thyroid, and surgery was performed. Based additional histopathological findings, tumor finally diagnosed as CASTLE....
Background: Nontypeable Haemophilus influenzae (NTHi)-caused acute otitis media persists even after antimicrobial treatment, presumably as a result of biofilm formation. It is urgent to establish an alternative treatment against that effectively deals with NTHi biofilm. Methods: An otopathogenic clinical strain IH-202 isolated from the middle ear fluid intractable pediatric cases was used in study. Antimicrobial susceptibility and assay using agent tosufloxacin were performed. Results:...
The cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is an uncommon subtype PTC, and it associated with familial adenomatous polyposis (FAP).We describe a 32-year-old female who presented recurrent CMV-PTC FAP. Surgery performed after the disease resulted in left laryngeal nerve palsy due to formation strong scar initial operation. histopathological examination revealed without capsular invasion remnant tissue berry ligament. In addition, immunohistochemical analysis...
Abstract Carcinoma showing thymus-like differentiation (CASTLE) is a rare thyroid cancer. This the first report of case concurrent occurrence CASTLE with papillary carcinoma (PTC). A 66-year-old male patient had hoarseness right vocal cord paralysis. Ultrasonography revealed hypoechoic nodule in inferior pole lobe. Ultrasound-guided fine-needle aspiration cytology suggested differentiated The underwent total thyroidectomy neck dissection. Pathological examination two different cancers: and...
Parathyroid cysts are comparatively rare, and often difficult to differentiate from thyroid preoperatively. Therefore, a definitive diagnosis of parathyroid can be made only after surgery in most patients. We report two cases cysts. classified as functional or non-functional, depending on whether the patient exhibits features hyperparathyroidism not. Both our reported here were having non-functional It is distinguish based clinical radiological findings alone. has been that analysis cyst...