Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break...

The management of abscess wounds induced by antibiotic-resistant bacterial infections has become increasingly formidable due to the widespread overutilization and misuse antimicrobial agents. This study presents an innovative dissolvable microneedle (MN) patch incorporating Au@ZnO/Ce nanocomposites vancomycin (AZC/Van@MN), exhibiting robust anti-inflammatory properties, meticulously engineered for therapeutic intervention wounds. developed AZC/Van@MN demonstrates exceptional biocompatibility...

Corticosteroid injections for hand tendinitis can lead to a rare significant complication of tendon spontaneous rupture. However, only sporadic cases were reported in the literature before. This study was designed gauge clinical effect repair patients rupture after corticosteroid injection and analyze our experience. retrospective observational 13 (8 women 5 men) operated between July 2011 December 2015 injection. Demographic data, features, imaging surgical treatments carefully reviewed....

An increasing number of patients with synchronous esophageal cancer (EC) and gastric (GC) have been diagnosed in recent years. Colon or jejunal interposition for reconstruction has frequently performed. This study aimed to evaluate the technical feasibility a new surgical procedure thoracic middle-lower segment EC distal GC.

Abstract Rationale: Cervical ribs are rare conditions, occurring in 0.05% to 3.0% of the population. This manuscript reports a case arterial thoracic outlet syndrome (ATOS) associated with this congenital anomaly. Patient concerns: We report 32-year-old female worker presenting pain her left upper-extremity for 7 months. Her hand became paler and cold when temperature decreased, symptoms could not be eased through rest, physiotherapy drugs medication. Diagnoses: Compression subclavian artery...

Background The medial sural artery perforator (MSAP) flap has become a popular target in head and neck reconstruction. This many advantages compared with other free flaps but not yet been used the reconstruction of circumferential haryngoesophageal defects. Methods Reconstruction pharyngoesophageal defects using MSAP was performed 4 patients. design based on perforators, which were confirmed by endoscopy. tubed anastomosed end to esophagus. superior thyroid arteries, whereas vein internal...

Aim: The present prospective observational study investigates the safety of transnasal percutaneous endoscopic gastrostomy (T‐PEG) carried out by a single physician using an ultrathin endoscope. Methods: A endoscopist attempted unsedated insertion 20‐Fr PEG tube pull‐method in 31 dysphagic patients: 11 females and 20 males aged 76.5 ± 10.6 (46–96) years, 5‐mm‐diameter indications for PEG, cardiopulmonary function before after T‐PEG, operation time, success or failure, any immediate adverse...

Abstract Background Transbronchial needle aspiration (TBNA) is a minimally invasive procedure performed to diagnose lymph node (LN) adenopathy. TBNA with and without endobronchial ultrasound (EBUS) guidance has high diagnostic yield for malignant LN enlargement, but the value diagnosing benign enlargement been less thoroughly investigated. Methods We retrospectively evaluated 3540 patients mediastinal who received TBNA. One hundred sixty-six lymphadenopathy were included 293 LNs biopsied. A...

Rosai-Dorfman disease (RDD) is an idiopathic histiocytic proliferative disorder characterized by sinus histiocytosis and massive lymphadenopathy. Extranodal central nervous system (CNS) involvement unusual. We describe two distinctly rare cases of isolated intradural RDD the spine without cervical report our experience in management patients with RDD. The first patient had ventral lesions, radiologically favour multiple spinal meningiomas, second presented extramedually lesion, extending...

Background: Transbronchial needle aspiration (TBNA) is a classical technique for diagnosing mediastinal-hilar lymph node enlargement. However, the diagnostic value of conventional TBNA (cTBNA) limited in small nodes. Methods: Here, we generated an innovative multi-dimensional virtual map on top Wang’s using Lungpoint Virtual Bronchoscopic Navigation System. Results: The bronchoscopic navigation (VBN) system was combined with computed tomography (CT) images to generate extrabronchial,...

Background Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating stroke subtype with high morbidity and mortality. Although several studies have developed prediction model in aSAH to predict individual outcomes, few addressed short-term mortality patients requiring mechanical ventilation. The study aimed construct user-friendly nomogram provide simple, precise, personalized of 30-day Methods We conducted post-hoc analysis based on retrospective French university hospital intensive care...

In the post-pandemic era, there is a need for medical professionals with creativity, clinical expertise, and social responsibility. The Chinese government issued directive to enhance "Five Characteristics" perceptions of students, incorporating moral integrity adeptness in saving lives aiding injured, embracing compassionate approach practice, possessing knowledge essential academic distinction, mastering technical artistry applying scientific methodologies. purpose this study was...

Abstract Background Dysfunction of cholesterol metabolism may be associated with low skeletal muscle mass. This study aimed to explore the relationship between mass and metabolic disorders in adults. Methods The data a total 5949 people complete medical history data, biochemical body composition analysis were recruited. According serum cholesterol, density lipoprotein (LDL), high (HDL) nonHDL, population was divided into disorder group normal group. Independent sample t tests, chi-square...

Aortoenteric fistula in a patient with right common iliac aortic aneurysm

Integrated avulsion of the nipple by human bite is not common. We treated a patient whose left had been completely avulsed modifing as free skin graft and reconstructing pillar-like fascia flap core to reshape configuration nipple.

Supplemented Erzhi Wan (SEZW) is a Traditional Chinese Medicine commonly used in the treatment of androgenetic alopecia (AGA). This study aims to verify effectiveness SEZW for AGA mice and explore potential molecular mechanisms underlying its function using network pharmacology docking.Forty were divided into five groups: Control, AGA-model, AGA-Positive, Low Dose, High Dose. Hair regrowth was evaluated by scoring hair on days 0, 14, 28 post-treatment weighing mouse day post-treatment. The...