Abstract Background Epigenetic modifications have been proved to play important roles in the spinal degenerative diseases. As a type of noncoding RNA, microRNA (miRNA) is vital class regulatory factor epigenetic modifications, while role miRNAs regulation ligamentum flavum hypertrophy (LFH) has not fully investigated. Methods The miRNA sequencing analysis was used explore change expression during fibrosis (LF) cells caused by TGF-β1 (10 ng/ml). downregulated miR-335-3p selected investigate...

The authors investigated the relation between Hounsfield unit (HU) values measured on CT and risk of pedicle screw loosening in patients who underwent lumbar fixation for degenerative spine disease.

Study Design. Retrospective analysis. Objective. To investigate the prevalence of osteoporosis (OP) in patients undergoing lumbar fusion for degenerative diseases (LDD). Summary Background Data. OP is related to many complications after with LDD. There are sparse data on among this specific population. Moreover, LDD can falsely elevate bone mineral density measured by dual energy x-ray absorptiometry (DXA), leading unreliable diagnostic results. Computed tomography (CT) Hounsfield unit (HU)...

OBJECTIVE The authors aimed to compare the efficacy of lumbar vertebral body Hounsfield units (HUs) and pedicle HUs at predicting screw loosening. METHODS retrospectively assessed 143 patients with L3–5 instrumentation. were classified into one two groups based on status their L3 screws (a loosening group or a control group). measured using preoperative CT scans, in ways: by excluding including cortical bone. RESULTS rate was 20.3% (n = 29/143) 12-month follow-up. lower than those (vertebral...

To investigate the biomechanical changes in proximal adjacent segment with different grades of degeneration after posterior lumbar interbody fusion (PLIF). We created three finite element models L3–5 (healthy, mild, and moderate) at L3–4 that were developed by changing disc height material properties nucleus pulposus. The L4–5 operated cages pedicle screws. All loaded a compressive pre-load 400 N bending moment 10 planes to recreate flexion, extension, lateral bending, axial rotation. range...

Background: The main function of robots in spine surgery is to assist with pedicle screw placement. Laminectomy, which as important placement, lacks a mature robot-assisted system. aims this study were introduce the first autonomous laminectomy robot, explore feasibility robotic laminectomy, and validate its accuracy using cadaveric model. Methods: Forty vertebrae from 4 cadavers included study; 7 thoracic 3 lumbar randomly selected each cadaver. surgeon was able plan path based on computed...

ABSTRACT Objective During percutaneous endoscopic interlaminar discectomy (PEID), a range of technologies including medical robotics, visual navigation, and spatial registration have been proposed to expand the application scope success rate minimally invasive surgery. The use robotic technology in surgery is conducive improving accuracy reducing risk. This study aims introduce precise efficient targeting method tailored for robot‐assisted positioning under C‐arm fluoroscopy inPEID. Methods...

The application of robots in the field pedicle screw placement has achieved great success. However, decompressive laminectomy, a step that is just as critical placement, does not have mature robot-assisted system. To address this lack, authors designed collaborative spine robot system to assist with laminectomy. In study, they aimed investigate reliability novel spinal and compare it manual laminectomy (ML).Thirty vitro porcine lumbar vertebral specimens were obtained experimental bone...

OBJECTIVE This study aimed to quantify pre- and postoperative paraspinal muscular variation following posterior lumbar interbody fusion (PLIF) in patients with degenerative spinal stenosis (DLSS) measure the association of this adjacent-segment degeneration (ASD). METHODS Data from 149 who underwent L4–S1 PLIF for DLSS were collected. Patients divided into radiologically confirmed ASD control groups according follow-up radiological findings. MRI was performed before surgery at last...

OBJECTIVE This study aimed to introduce a novel artificial intelligence (AI)–based robotic system for autonomous planning of spinal posterior decompression and verify its accuracy through cadaveric model. METHODS Seventeen vertebrae from 3 cadavers were included in the study. Three thoracic (T9–11) lumbar (L3–5) selected each cadaver. After obtaining CT data, independently planned laminectomy path based on AI algorithms before surgical procedure automatically performed during procedure. A...

This study aimed to analyze the effect of patient positions on lordosis and scoliosis patients with degenerative lumbar (DLS). Seventy-seven DLS were retrospectively analyzed. We measured Cobb's angle preoperative upright x-rays magnetic resonance imagings in supine position. The surgical segments intraoperative prone position radiographs 20 compare that standing Paired t tests performed investigate parameters sample. From whole increased (29.2 ± 15.7 degree vs. 34.9 11.2 degree), decreased...

When choosing S1 as the lowest level of instrumentation, there are many complications may come out such screw loosening. Facing this problem, has been various techniques for protection including sacropelvic fixation, bicortical or tricortical insertion screw.This study aimed to explore risk factors loosening, then demonstrate relationship between loosening and postoperative outcome patients with degenerative lumbar scoliosis (DLS).Patients who underwent lumbosacral fixation DLS were...

A basic experimental study.To elucidate the role and mechanism of interleukin (IL)-17A in thoracic ossification ligamentum flavum (TOLF).TOLF is characterized by replacement with ossified tissue one leading causes spinal stenosis. IL-17A an important member IL-17 family that has received widespread attention for its key contributions to regulation bone metabolism heterotopic ossification. However, it unclear whether involved TOLF.Cell counting kit-8 assay 5-ethynyl-2'-deoxyuridine staining...

Abstract Background It was reported the paraspinal muscle played an important role in spinal stability. The preoperative related to S1 screw loosening. But relationship between and postoperative change of psoas major (PS) pedicle loosening degenerative lumbar stenosis (DLSS) patients has not been reported. This study investigated effects follow-up variations on first sacral vertebra (S1) with DLSS. Methods 212 DLSS who underwent surgery were included. divided into group non-loosening group....

Abstract Rationale: Cervical ribs are rare conditions, occurring in 0.05% to 3.0% of the population. This manuscript reports a case arterial thoracic outlet syndrome (ATOS) associated with this congenital anomaly. Patient concerns: We report 32-year-old female worker presenting pain her left upper-extremity for 7 months. Her hand became paler and cold when temperature decreased, symptoms could not be eased through rest, physiotherapy drugs medication. Diagnoses: Compression subclavian artery...

Prospective radiological analysis.To investigate the characteristics of sagittal spinopelvic alignment in standing and sitting positions under Roussouly classification a healthy population.This study using lateral radiographs included 143 volunteers whose parameters were measured. The compared positions. lumbo-pelvic profile was identified according to classification. differences values between analyzed. different frequencies unchanged apex assessed.All parameter except thoracolumbar angle...

Abstract Background Inadequate release of the posterior spinal bone elements may hinder correction lumbosacral fractional curve in degenerative lumbar scoliosis, since junction tends to be particularly rigid and already fused into an abnormal position. The purpose this study was evaluate surgical outcome complications column osteotomy plus unilateral cage strutting technique on concavity for scoliosis patients. Methods Thirty-two patients with more than 15° that were surgically treated by...

Abstract Background Robot‐assisted pedicle screw insertion has gained popularity in the spinal surgery field. Due to high cost, these robots are not extensively applied clinical surgeries. Developing an effective robot system with low cost and acceptability is one of future trends. Methods We developed a novel fluoroscopy‐based for insertion. Four live pigs were conducted percutaneous was performed on left side pedicle, while right opposite placed by freehand. The respect accuracy, surgical...

Abstract Background To assess the incidence and causative factors of unplanned hospital readmission within 90 days after surgical treatment thoracic spinal stenosis (TSS). Methods Hospital administrative database was queried to identify patients who underwent TSS from July 2010 through December 2017. All readmissions discharge were reviewed for causes rate calculated. Patients matched 1:3 a control cohort without readmission. Results Twenty-one (incidence 1.7 % in 1239 patients) presented...