A5067899566- Tuberculosis Research and Epidemiology
- RNA and protein synthesis mechanisms
- Neonatal and fetal brain pathology
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Functional Brain Connectivity Studies
- Antimicrobial Resistance in Staphylococcus
- Respiratory Support and Mechanisms
- Hepatitis B Virus Studies
- Domain Adaptation and Few-Shot Learning
- Nosocomial Infections in ICU
- Advanced Neuroimaging Techniques and Applications
- Hepatitis C virus research
- Pneumonia and Respiratory Infections
- Antimicrobial Peptides and Activities
- Immunotherapy and Immune Responses
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Fetal and Pediatric Neurological Disorders
- Immune Cell Function and Interaction
- Bacterial biofilms and quorum sensing
- Peptidase Inhibition and Analysis
- Sepsis Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Pneumocystis jirovecii pneumonia detection and treatment
University of California, San Francisco
2018-2025
Affiliated Hospital of Guizhou Medical University
2025
Guizhou University
2024-2025
Jiangmen Central Hospital
2012-2024
Xidian University
2024
Lanzhou University
2024
Zhejiang University
2020-2022
Guangzhou Medical University
2008-2021
Second Affiliated Hospital of Guangzhou Medical University
2021
Sun Yat-sen University
2020
Peptide modulators targeting protein–protein interactions (PPIs) exhibit greater potential than small-molecule drugs in several important aspects including facile modification and relative large contact surface area. Stabilized peptides constructed by variable chemistry methods improved peptide stability cell permeability compared to that of the linears. Herein, we designed a stabilized peptide-based proteolysis-targeting chimera (PROTAC) estrogen receptor α (ERα) tethering an N-terminal...
Multi-modal pre-training models have been intensively explored to bridge vision and language in recent years. However, most of them explicitly model the cross-modal interaction between image-text pairs, by assuming that there exists strong semantic correlation text image modalities. Since this assumption is often invalid real-world scenarios, we choose implicitly for large-scale multi-modal pre-training, which focus Chinese project `WenLan' led our team. Specifically, with weak over propose...
Mycobacterium tuberculosis (Mtb) infects lung myeloid cells, but the specific Mtb-permissive cells and host mechanisms supporting Mtb persistence during chronic infection are incompletely characterized. We report that after development of T cell responses, CD11c lo monocyte-derived harbor more live than alveolar macrophages (AM), neutrophils, hi cells. Transcriptomic functional studies revealed lysosome pathway is underexpressed in this highly permissive subset, characterized by less...
Abstract Real-time physiological information monitoring can predict and prevent disease, or improve treatment by early diagnosis. A comprehensive continuous of human health requires highly integrated wearable comfortable sensing devices. To address this need, we propose a low-cost electronic fabric-enabled multifunctional flexible integration platform that includes pressure sensor for postural pressure, humidity the skin surface, temperature visualizing ambient around body. Thanks to unique...
Mycobacterium tuberculosis (MTB) ESX-1, a type VII secretion system, is key virulence determinant contributing to MTB’s survival within lung mononuclear phagocytes (MNPs), but its effect on MNP recruitment and differentiation remains unknown. Here, using multiple single-cell RNA sequencing techniques, we studied the role of ESX-1 in heterogeneity response mice murine bone marrow–derived macrophages (BMDM). We found that required for MTB recruit diverse subsets with high burden. Further,...
Lack of specific and efficient therapy leads to the high mortality rate acute lung injury (ALI) respiratory distress syndrome (ARDS). Losartan is a potent pharmaceutical drug for ALI/ARDS. However, protective effects mechanisms losartan remain incompletely known. This study evaluates on ALI/ARDS further investigates possible these effects. Mice received i.p. injections AT1 inhibitor (15 mg/kg), or control vehicle, half hour after cecal ligation puncture (CLP). Plasma TNF-α, IL-1β, IL-6...
Metagenome next-generation sequencing (mNGS) is a valuable diagnostic tool that can be used for the identification of early pathogens acute respiratory distress syndrome (ARDS) in severe pneumonia. Little known about use this technology clinical application and evaluation prognostic value ARDS.We performed retrospective cohort study patients with ARDS caused by Samples were collected from intensive care unit (ICU) Jiangmen Central Hospital January 2018 to August 2019. The no-next generation...
Genome engineering of primary human cells with CRISPR-Cas9 has revolutionized experimental and therapeutic approaches to cell biology, but myeloid-lineage have remained largely genetically intractable. We present a method for the delivery ribonucleoprotein (RNP) complexes by nucleofection directly into CD14+ monocytes purified from peripheral blood, leading high rates precise gene knockout. These can be efficiently differentiated monocyte-derived macrophages or dendritic cells. This process...
Osteoporosis (OP) is a metabolic disease characterized by decreased bone mass and increased risk of fragility fractures, which significantly reduces the quality life. Stem cell-based therapies, especially using marrow mesenchymal stem cells (BMSCs), are promising strategy for treating OP. Nevertheless, survival differentiation rates transplanted BMSCs low, limits their therapeutic efficiency. Icariin (ICA) traditional Chinese medicine formulation that prescribed tonifying kidneys. It also...
The human brain demonstrates anatomical and functional lateralization/asymmetry between the left right hemispheres, such asymmetry is known to start from early age of life. However, how changes with development during infancy remained unknown. In this study, we aimed systematically investigate spatiotemporal pattern in healthy preterm-born infants first-half-year development, using high angular resolution diffusion MRI. Sixty-five (gestational 25.3–36.6 weeks) were scanned postmenstrual...
Previous studies have reported the changes of magnetic susceptibility induced by iron deposition in hippocampus Alzheimer's disease (AD) brains. It is well-known that divided into well-defined laminar architecture, which, however, difficult to be resolved with in-vivo MRI due limited imaging resolution. The present study aims investigate layer-specific AD patients using high-resolution ex-vivo MRI, and elucidate its relationship beta amyloid (Aβ) tau protein histology. We performed...
Background: Acute respiratory distress syndrome (ARDS) is an unresolved challenge in the field of and critical care, changes lung microbiome during development ARDS their clinical diagnostic value remain unclear. This study aimed to explore role disease progression patients with sepsis-induced potential therapeutic targets. Methods: Patients were divided into two groups according initial site infection, intrapulmonary infection (ARDSp, 111 cases) extrapulmonary (ARDSexp, 45 cases), a total...
Abstract SarA (staphylococcal accessory protein A), MgrA (MarR family of global transcriptional regulator and SarZ (a paralogue SarA) play critical roles in modulating the virulence, drug resistance autolysis Staphylococcus aureus . Recently, eukaryotic‐like Ser/Thr kinase/phosphatases (Stk1/Stp1) were found to modulate phosphorylation these regulators as well staphylococcal virulence. Importantly, an stp1 ‐deficient strain showed significant virulence reduction mice, indicative Stp1 a...
Cytolytic peptides are an emerging class of promising cancer therapeutics shown to overcome drug resistance. They eliminate cells via disruption the phospholipid bilayer cell membranes, a mechanism that differentiates it from traditional treatments. However, applications lytic systematic administration hampered by nonspecific toxicity. Here, we describe activatable, masked conjugated with anionic cleavable linker sensitive matrix metalloproteinases (Ac-w-βA-e8-XPLG*LAG-klUklUkklUklUk-NH2;...
Abstract The thalamus plays crucial roles in consciousness generation and information processing. Previous evidence suggests that disorder of (DOC) caused by severe brain injury, is potentially related to thalamic abnormalities. However, how the morphology microstructure change subfields thalamocortical fiber pathways patients with DOC, relationships between these changes status remain unclear. Here, we generated individual-specific parcellation 10 DOC healthy controls (HC) via a novel...
The eukaryotic-like Ser/Thr kinase Stk1 is crucial for virulence, cell wall biosynthesis, and drug susceptibility in methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA). Importantly, MRSA lacking become sensitive to β-lactam antibiotics, implying that could be an alternative target combination therapy. However, the autophosphorylation mechanism of remains elusive. Using a phosphoproteomic study, we identified six vivo phosphorylated activation loop residues (Ser159, Thr161,...