A5010562965- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Gut microbiota and health
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Domain Adaptation and Few-Shot Learning
- Functional Brain Connectivity Studies
- Nanoplatforms for cancer theranostics
- Sulfur Compounds in Biology
- Liver Disease Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Surgical site infection prevention
- Anorectal Disease Treatments and Outcomes
- Congenital heart defects research
- Dementia and Cognitive Impairment Research
- Tuberculosis Research and Epidemiology
- Immune cells in cancer
- Plant Genetic and Mutation Studies
- Alzheimer's disease research and treatments
- Genomics, phytochemicals, and oxidative stress
- Oral Health Pathology and Treatment
- RNA Interference and Gene Delivery
- Spaceflight effects on biology
- Extracellular vesicles in disease
Sun Yat-sen Memorial Hospital
2023-2024
Sun Yat-sen University
2023-2024
Huazhong University of Science and Technology
2024
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Union Hospital
2024
Zhejiang University
2020-2022
Xi'an Jiaotong University
2022
Soochow University
2020-2021
Deyang Stomatological Hospital
2019
The fetal brains experience rapid and complex development
Our aims were to better understand the interplay of diet and gut microbiota in Crohn's disease [CD], taking advantage a new-onset treatment-naïve CD cohort. We focus on phenylacetylglutamine [PAGln], diet-derived meta-organismal prothrombotic metabolite.We collected faecal serum samples from cohort [n = 136] healthy controls 126] prior treatment, quantified PAGln using LC-MS/MS. Diet was assessed food-frequency questionnaires. Mice [C57BL/6] fed high/low-protein diets administered dextran...
Abstract Background H 2 S imbalances in the intestinal tract trigger Crohn's disease (CD), a chronic inflammatory gastrointestinal disorder characterized by microbiota dysbiosis and barrier dysfunction. However, comprehensive understanding of generation gut, contributions both host to systemic levels CD, remain be elucidated. This investigation aimed enhance comprehension regarding sulfidogenic potential human gut microbiota. Results Our analysis treatment-naive CD cohorts' fecal metagenomic...
High expression of programmed death ligand 1 (PD-L1) and strong immune evasion ability the tumor microenvironment (TME) are maintained through mutual regulation between different stromal cells, which causes obstructions for cancer immunotherapy, especially immunosuppressive M2-like phenotype tumor-associated macrophages (TAMs). Repolarization TAMs to M1-like could secrete proinflammatory cytokines reverse state TME. However, we found that reactive oxygen species (ROS) generated by...
Previous studies have reported the changes of magnetic susceptibility induced by iron deposition in hippocampus Alzheimer's disease (AD) brains. It is well-known that divided into well-defined laminar architecture, which, however, difficult to be resolved with in-vivo MRI due limited imaging resolution. The present study aims investigate layer-specific AD patients using high-resolution ex-vivo MRI, and elucidate its relationship beta amyloid (Aβ) tau protein histology. We performed...
Accumulation of senescent cells is a recognized feature in hepatocellular carcinoma (HCC), but their specific types and prognostic implications remain under investigation. This study aimed to delineate cell patterns HCC using publicly available bulk single-cell mRNA sequencing data. Through gene expression set enrichment analysis, we identified distinct within samples. Notably, unconventional T cells, specifically natural killer γδT were found be the predominant types. These exhibited...
With the advent of long-duration space explorations, ionizing radiation (IR) may pose a constant threat to astronauts without protection Earth’s magnetic field, or hypomagnetic field (HMF). However, potential biological effects HMF on cellular response IR have not been well characterized so far. In this study, immortalized human bronchial epithelial cells were exposed X-rays under either geomagnetic (GMF, ~50 uT) (<50 nT) culture condition. A significant increase cell survival rate in...
The embryonic mouse brain undergoes drastic changes in establishing basic anatomical compartments and laying out major axonal connections of the developing brain. Correlating with gene-expression patterns is an essential step toward understanding mechanisms regulating development. Traditionally, this done a cross-sectional manner, but dynamic nature development calls for probing gene-neuroanatomy interactions combined spatiotemporal domain. Here, we present four-dimensional (4D) continuum...
Objectives: This study assessed the associations between long-term trajectories of percentage energy from fat (PEF) and obesity among Chinese adults. Methods: Longitudinal data collected by China Health Nutrition Survey 1991 to 2015 were analyzed. A body mass index ≥28.0 was defined as general obesity. Participants’ baseline PEF levels categorized lower than recommendation Dietary Guideline (<20%), meeting (20−30%), higher (>30%). Patterns identified latent class trajectory analysis for...
Abstract High‐resolution ex vivo diffusion MRI (dMRI) can provide exquisite mesoscopic details and microstructural information of the human brain. Microstructural pattern anterior part hippocampus, however, has not been well elucidated with dMRI, either in normal or disease conditions. The present study collected high‐resolution (0.1 mm isotropic) dMRI post‐mortem hippocampal tissues from four Alzheimer's diseases (AD), three primary age‐related tauopathy (PART), healthy control (HC) brains...
Abstract The fetal brains experience rapid and complex development in utero during the second third trimesters. MRI atlas of brain this period enables us to quantify normal spatiotemporal domain. In study, we constructed a high quality between 23-38 weeks gestational age (GA) from 90 healthy Chinese fetuses using pairwise groupwise registration-based pipeline. We quantified cortical morphology characterized developmental trajectories each morphological index. thickness exhibited biphasic...
Radiofrequency ablation (RFA) is a safe and minimally invasive procedure had been recommended as the first-line treatment for early stage hepatocellular carcinoma (HCC) by NCCN CSCO guideline. However, it reported that insufficient radiofrequency (IRFA) was main cause of recurrence metastasis patients who underwent RFA. Angiogenesis in residual tumor after IRFA one reasons progression. Although variety antiangiogenesis drugs clinically applied, systemic side effects resistance may lead to...
<title>Abstract</title> Background H<sub>2</sub>S imbalances in the intestinal tract trigger Crohn's disease (CD), a chronic inflammatory gastrointestinal disorder characterized by microbiota dysbiosis and barrier dysfunction. However, comprehensive understanding of generation gut, contributions both host to systemic levels CD, remain be elucidated. This investigation aimed enhance comprehension regarding sulfidogenic potential human gut microbiota. Results Our analysis treatment-naive CD...
Chemotherapy is important in the systemic therapy for breast cancer. However, after chemotherapy, left living tumour cells are more progressive. There an urgent need to study underlying mechanism which still unclear further improve therapeutic efficacy of chemotherapy Here we find a pro-tumour effect apoptotic induced by mediated new subset macrophages undergoing LC3-associated phagocytosis (LAP). By transferring exosomal S100A11 into macrophage exhibits phenotype than classic M2-type...
Abstract Fetal brain MRI has become an important tool for in utero assessment of development and disorders. However, quantitative analysis fetal remains difficult, partially due to the limited tools automated preprocessing lack normative templates. In this paper, we proposed pipeline extraction, super-resolution reconstruction, atlasing quantitatively map during mid-to-late gestation a Chinese population. First, designed U-net convolutional neural network which achieved average accuracy 97%....