A5081777043- Aortic Disease and Treatment Approaches
- Gut microbiota and health
- Cardiac Valve Diseases and Treatments
- Mental Health via Writing
- Diet and metabolism studies
- Aortic aneurysm repair treatments
- Autophagy in Disease and Therapy
- Hate Speech and Cyberbullying Detection
- Dietary Effects on Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Artery Disease Management
- Machine Learning in Healthcare
- Pancreatic function and diabetes
- Mesenchymal stem cell research
- Neurological Disorders and Treatments
- Natural Compounds in Disease Treatment
- Artificial Intelligence in Healthcare
- Digital Mental Health Interventions
- Sentiment Analysis and Opinion Mining
- Venous Thromboembolism Diagnosis and Management
- Hormonal and reproductive studies
- Clinical Nutrition and Gastroenterology
- Metabolomics and Mass Spectrometry Studies
- Lipoproteins and Cardiovascular Health
- Misinformation and Its Impacts
Sun Yat-sen University
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Our aims were to better understand the interplay of diet and gut microbiota in Crohn's disease [CD], taking advantage a new-onset treatment-naïve CD cohort. We focus on phenylacetylglutamine [PAGln], diet-derived meta-organismal prothrombotic metabolite.We collected faecal serum samples from cohort [n = 136] healthy controls 126] prior treatment, quantified PAGln using LC-MS/MS. Diet was assessed food-frequency questionnaires. Mice [C57BL/6] fed high/low-protein diets administered dextran...
Social media has become an important source for understanding mental health, providing researchers with a way to detect conditions like depression from user-generated posts. This tutorial provides practical guidance address common challenges in applying machine learning and deep methods health detection on these platforms. It focuses strategies working diverse datasets, improving text preprocessing, addressing issues such as imbalanced data model evaluation. Real-world examples step-by-step...
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established NAFLD mouse model through high-fat diet (HFD) and implemented 16:8 TRF for duration of 6 weeks. We that remarkably alleviated hepatic steatosis HFD mice. Of note, aldehyde oxidase 1 (AOX1), key enzyme...
Obesity is one of the most prevalent chronic metabolic diseases, and induction apoptosis in preadipocytes adipocytes a potential strategy to treat obesity. Celastrol represents robust anti-obesity phytochemicals so far, yet its direct binding target remains elusive. Here, we determined that celastrol could induce via mitochondrial mediated pathway. Further study clarified inhibited fusion autophagosome lysosome prohibit autophagy, leading cell apoptosis. By conducting virtual screening...
Glycoursodeoxycholic acid (GUDCA) has been acknowledged for its ability to regulate lipid homeostasis and provide benefits various metabolic disorders. However, the impact of GUDCA on arterial thrombotic events remains unexplored. The objective this study is examine effects thrombogenesis elucidate underlying mechanisms.
The global rise in depression necessitates innovative detection methods for early intervention. Social media provides a unique opportunity to identify through user-generated posts. This systematic review evaluates machine learning (ML) models on social media, focusing biases and methodological challenges throughout the ML lifecycle. A search of PubMed, IEEE Xplore, Google Scholar identified 47 relevant studies published after 2010. Prediction model Risk Of Bias ASsessment Tool (PROBAST) was...
This report describes the recanalization of iliac-femoral-popliteal-below knee super-long chronic total occlusion (CTO) in a patient with limb-threatening ischemia. We attempted SAFARI technique but failed because retrograde guidewire could not re-enter into true lumen common iliac artery. Then we conducted an additional puncture occluded femoral artery and created "flossing"-type to achieve revascularization. combined techniques artery, which may represent new strategy for revascularizing...
Spontaneous isolated abdominal aortic dissection (SIAAD) is a rare emergency and not yet fully understood. This study aims to report the characteristics treatments of 31 patients with SIAAD in past 12 years.A total consecutive between 2010 2022 were included. The clinical manifestations, treatment strategies, outcomes reviewed. Following SVS/STS reporting standard, we compared different locations primary entry, or numbers dissected zones. Furthermore, effects surgical conservative therapies...
Abstract: OBJECTIVES: Aortic dissection with aberrant right subclavian artery (ARSA) is rare but fatal, its optimal treatment remaining controversial. In this retrospective study, we presented the outcome of endovascular repair for these patients, aiming to evaluate efficacy and safety technique. MATERIALS AND METHODS: From January 2016 2022, seven patients diagnosed aortic ARSA in First Affiliated Hospital Sun Yat-sen University were enrolled. All received thoracic (TEVAR) within 1 week...
Background: Aortic dissection (AD) is a serious aortic disease. Although current imaging methods can provide accurate diagnosis for AD, they do not include essential biological information. The aim of this study to identify plasma metabolites the risk and severity type B AD (TBAD). Methods: In cross-sectional study, we enrolled 16 hypertensive patients with TBAD 7 without in Jieyang People’s Hospital between December 2021 April 2022. After metabolomics analysis, score (MRS) model was...