A5091302480- Diet and metabolism studies
- Dietary Effects on Health
- Aortic Disease and Treatment Approaches
- Liver Disease Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Neurological Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Aortic aneurysm repair treatments
- Infectious Aortic and Vascular Conditions
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Angiogenesis and VEGF in Cancer
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacology and Obesity Treatment
- Hormonal and reproductive studies
- Central Venous Catheters and Hemodialysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Coronary Interventions and Diagnostics
- Vascular anomalies and interventions
Sun Yat-sen University
2021-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Foam cell formation has traditionally been attributed to macrophages; however, emerging evidence highlights vascular smooth muscle cells (VSMCs) as another significant contributor. Here, we found TMEM41B is significantly upregulated in VSMCs of both human atherosclerotic (AS) lesions and murine models. specific silencing expression apolipoprotein E-deficient (ApoE-/-) mice markedly reduced plaque size macrophage infiltration. Overexpressing cultured alters intracellular lipid profiles...
Background: Restenosis (RS) poses a significant concern, leading to recurrent ischemia and the potential for amputation following intraluminal angioplasty in treatment of Peripheral Artery Disease (PAD). Through microRNA microarray analysis, study detected downregulation miR-199a-5p within arterial smooth muscle cells (ASMCs) associated with RS. Objective: This research aims explore possible function underlying mechanisms context Methods: Primary ASMCs were extracted from femoral arteries...
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established NAFLD mouse model through high-fat diet (HFD) and implemented 16:8 TRF for duration of 6 weeks. We that remarkably alleviated hepatic steatosis HFD mice. Of note, aldehyde oxidase 1 (AOX1), key enzyme...
To evaluate the effectiveness and safety of using off-the-shelf "Octopus" technique to treat ruptured or symptomatic thoracoabdominal aortic aneurysm (TAAA) pararenal abdominal (PRAAA).All cases who underwent from May 2016 2019 at our center were retrospectively analyzed. A total 10 (8 males) included. The mean age was 54.5±14.2 years (range: 31-80 years). Eight presented as rupture impending accepted emergency repair. Technical success, defined by placement all endografts planned, achieved...
Glycoursodeoxycholic acid (GUDCA) has been acknowledged for its ability to regulate lipid homeostasis and provide benefits various metabolic disorders. However, the impact of GUDCA on arterial thrombotic events remains unexplored. The objective this study is examine effects thrombogenesis elucidate underlying mechanisms.
Background: Arterial thrombotic disease has long been a crucial worldwide health concern. Metabolic disorders have validated to enhance platelet reactivity, thereby augmenting the risk. Recent investigations highlighted metabolic improving effect of alternate day fasting (ADF). However, its impact on thrombosis remains unclear. Hypothesis: We hypothesize that ADF may reduce arterial risk through modulatory effect. Aims: To investigate effects thrombogenesis and unravel underlying mechanisms....
Background: Atherosclerotic cardiovascular disease (ASCVD) stands as the foremost cause of mortality and disability among adults worldwide. Despite non-alcoholic fatty liver (NAFLD) has been well-characterized an independent risk factor atherosclerosis (AS), precise underlying mechanisms remain poorly elucidated. We recently identified N-methyl-2-pyridone-5-carboxamide (2PY), main end product nicotinamide in human, a pro-steatotic metabolite markedly elevated hepatic steatosis conditions....