A5070345166- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Congenital Heart Disease Studies
- Genomics, phytochemicals, and oxidative stress
- Aortic Disease and Treatment Approaches
- Protein Tyrosine Phosphatases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacology and Obesity Treatment
- Hormonal and reproductive studies
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Congenital heart defects research
- Neurological Disorders and Treatments
The First Affiliated Hospital, Sun Yat-sen University
2024-2025
Sun Yat-sen University
2024-2025
Guangdong Provincial People's Hospital
2023
South China University of Technology
2023
Guangdong Academy of Medical Sciences
2023
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established NAFLD mouse model through high-fat diet (HFD) and implemented 16:8 TRF for duration of 6 weeks. We that remarkably alleviated hepatic steatosis HFD mice. Of note, aldehyde oxidase 1 (AOX1), key enzyme...
Glycoursodeoxycholic acid (GUDCA) has been acknowledged for its ability to regulate lipid homeostasis and provide benefits various metabolic disorders. However, the impact of GUDCA on arterial thrombotic events remains unexplored. The objective this study is examine effects thrombogenesis elucidate underlying mechanisms.
Abstract Src-homology region 2 domain-containing phosphatase 1 (SHP-1) is considered an anti-inflammatory factor, but its role in chronic obstructive pulmonary disease (COPD) remains unknown. Herein, overexpression of SHP-1 was utilized to explore the functions COPD models established by stimulating 16HBE cells with cigarette smoke extracts (CSE) vitro . downregulated both patients and CES-treated cells. reinforced cell viability significantly prevented CSE-induced apoptosis Furthermore,...
Background: Arterial thrombotic disease has long been a crucial worldwide health concern. Metabolic disorders have validated to enhance platelet reactivity, thereby augmenting the risk. Recent investigations highlighted metabolic improving effect of alternate day fasting (ADF). However, its impact on thrombosis remains unclear. Hypothesis: We hypothesize that ADF may reduce arterial risk through modulatory effect. Aims: To investigate effects thrombogenesis and unravel underlying mechanisms....
Background: Atherosclerotic cardiovascular disease (ASCVD) stands as the foremost cause of mortality and disability among adults worldwide. Despite non-alcoholic fatty liver (NAFLD) has been well-characterized an independent risk factor atherosclerosis (AS), precise underlying mechanisms remain poorly elucidated. We recently identified N-methyl-2-pyridone-5-carboxamide (2PY), main end product nicotinamide in human, a pro-steatotic metabolite markedly elevated hepatic steatosis conditions....
Aortic dissection (AD) is a lethal cardiovascular disease that related to genetic mutation. This study showed the generation of induced pluripotent stem cell (iPSC) line (iPSC-ZPR-4-P10) from AD patients' peripheral blood mononuclear cells carried c.2635T > G mutation in MCTP2. The iPSC demonstrated normal karyotype and expression pluripotency markers, which could be an efficient tool better investigate mechanism aortic dissection.