A5063401702- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- Clinical Nutrition and Gastroenterology
- Micro and Nano Robotics
- Eicosanoids and Hypertension Pharmacology
- Abdominal Surgery and Complications
- Diet and metabolism studies
- Molecular Communication and Nanonetworks
- Clostridium difficile and Clostridium perfringens research
- Lipid Membrane Structure and Behavior
- Telomeres, Telomerase, and Senescence
- Metabolomics and Mass Spectrometry Studies
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Non-Invasive Vital Sign Monitoring
Dongguan People’s Hospital
2010-2024
Guangdong Medical College
2024
Southern Medical University
2020-2024
State Key Laboratory of Respiratory Disease
2008-2009
Guangzhou Medical University
2008-2009
Lack of specific and efficient therapy leads to the high mortality rate acute lung injury (ALI) respiratory distress syndrome (ARDS). Losartan is a potent pharmaceutical drug for ALI/ARDS. However, protective effects mechanisms losartan remain incompletely known. This study evaluates on ALI/ARDS further investigates possible these effects. Mice received i.p. injections AT1 inhibitor (15 mg/kg), or control vehicle, half hour after cecal ligation puncture (CLP). Plasma TNF-α, IL-1β, IL-6...
Abstract Acute lung injury (ALI) is a frequent and serious complication of sepsis with limited therapeutic options. Gaining insights into the inflammatory dysregulation that causes sepsis‐associated ALI can help develop new strategies. Herein, crucial role cell‐free mitochondrial DNA (cf‐mtDNA) in regulation alveolar macrophage activation during identified. Most importantly, biocompatible hybrid protein nanomotor (NM) composed recombinant deoxyribonuclease I (DNase‐I) human serum albumin...
Recent outbreaks of avian influenza and ongoing virus reassortment have drawn focus on spill-over infections. The increase in human infections with highly pathogenic H5N6 its high fatality rate posed a potential threat, necessitating the search for more effective treatment.
Corticosteroid is commonly used to reduce damage from inflammatory reactions in coronavirus disease 2019 (COVID-19). We aim determine the outcomes of corticosteroid use critically ill COVID-19 patients. Ninety six patients, hospitalized 14 hospitals outside Wuhan January 16 March 30, 2020 were enrolled this study. Among 96 critical 68 treated with (CS group), while 28 not corticosteroids (non-CS group). Multivariable logistic regression performed possible correlation between and treatment...
Avian influenza A (H7N9) viruses emerged in China 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles peripheral blood reflect host responses can help to elucidate pathogenesis.We correlated serial transcriptomic patients avian virus infection determined the biological significances from analysis.We found that specific gene expression were strongly Pao 2/Fio 2 viral load lower respiratory tract. Cell cycle leukocyte-related immunity...
The eicosanoid metabolic pathway is responsible for mediating the production of various inflammatory factors that are closely related to development and resolution inflammation. In biological matrices, major quantifying obstacles were shown be oxidation low quantities eicosanoids their metabolites. This study aimed develop a reliable, sensitive ultrahigh-performance liquid chromatography coupled tandem mass spectrometry (UPLC-MS/MS) method quantify in human serum. Solid-phase extraction...
Abstract Background Prior studies reported that 5 ~ 32% COVID-19 patients were critically ill, a situation poses great challenge for the management of and ICU resources. We aim to identify independent risk factors serve as prediction markers critical illness SARS-CoV-2 infection. Methods Fifty-two 200 non-critical nucleic acid positive hospitalized in 15 hospitals outside Wuhan from January 19 March 6, 2020 enrolled this study. Multivariable logistic regression LASSO performed illness....
Introduction SARS-CoV-2 infection drove senescent cells and the senescence-associated phenotypes were reported playing roles in disease progression, which contributes to severe COVID-19 related sequelae. Cdc42 is involved regulation of cellular senescence. This study, aimed investigate mechanism spike protein regulating senescence through Cdc42. Methods K18-hACE2 mice infected with Omicron BA.4 or stimulated airway, expression lung tissue detected. Overexpression exogenous incubation was...
The current COVID-19 pandemic is posing a major challenge to public health on global scale. While it generally believed that severe results from over-expression of inflammatory mediators (i.e., "cytokine storm"), still unclear whether and how co-infecting pathogens contribute disease pathogenesis. To address this, we followed the entire course in cases with or critical determine presence abundance all potential present-the total "infectome"-and they interact host immune system context...
Herbal medicine has a long history of use in the prevention and treatment disease is becoming increasingly popular globally. However, there are also widespread concerns about its safety. Among them, cardiotoxicity aconitine been described.We report case 61-year-old male with poisoning presenting malignant arrhythmia severe cardiogenic shock, which was successfully managed aggressive advanced life support heart transplantation.This first wherein vivo cardiac pathology obtained, confirming...
Heart failure is a condition caused by variety of pathophysiological factors. One important pathological change chronic heart myocardial hypertrophy. In recent years, several studies have found that dysregulated microRNAs are involved in regulating the process failure. this study, cardiac hypertrophy models were constructed using isoproterenol (ISO)-/angiotensin-II (Ang-II) to explore role miR-384-5p and its molecular mechanism vivo vitro. Echocardiography, invasive pressure-volume analysis...
Abstract To inform seroepidemiological studies, we characterized the IgG‐ responses in COVID‐19 patients against two major SARS‐CoV‐2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 sera collected up to 85 days post‐symptom onset 230 non‐COVID‐19 sera, including 27 SARS from 2003. Although average S N‐IgG titers were comparable, N‐responses more variable among individuals. S‐ N‐assay specificity with comparable at 97.5% 97.0%, respectively. Therefore, will make a better target...
Point-of-care ultrasonography is a non-invasive, convenient, and reproducible method used in the diagnosis of patients admitted to intensive care unit. We report case acute aortic dissection presenting as myocardial infarction cerebral confirmed through point-of-care ultrasonography. The patient received timely effective treatment. However, sensitivity cannot be overestimated, CTA still needs combined.
Abstract Sepsis is a life-threatening organ dysfunction caused by an unregulated host response to infection. It important clinical problem in acute and critical care. In recent years, with the increasing research on epidemiology, pathogenesis, diagnostic therapeutic strategies of sepsis, great progress has been made practice, but there still lack specific effective treatment plans. Curcuma longa, leafy plant ginger family, which common safe compound, multiple pharmacological actions,...
Abstract Background Recent increase in human infections of highly pathogenic avian influenza H5N6 virus and its high mortality have raised concerns. Methods To analyze evolution outcomes, longitudinal clinical data specimens were collected from five patients infected with after admission. All received antiviral treatment either sequentially or combination oseltamivir baloxavir. Severity illness, viral load sputum, urine blood, cytokine levels serum sputum serially analyzed. Results When...
Self-Propelled Proteomotors with active cf-mtDNA Clearance In article number 2301635, Lihan Shen, Fei Peng, Yingfeng Tu, and co-workers develop a novel DNase-I-powered nanomotor system which efficiently eliminates inhibits TLR9-mediated inflammatory activation of alveolar macrophages as strategy for sepsis-associated acute lung injury treatment.
Objective To study the impact on clinical outcomes of ARDS patients using PiCCO monitoring.Methods A total 28 were randomly divided into intervention group (n =15) and control =13),and received monitoring was not.The change blood lactic acid oxygenation index measured in first week PiCCO.Patients followed until time hospital discharge to determine days mechanical ventilation,ICU length stay,days vasoactive agent support 28-day mortality.Results There not significant differences between two...