A5046520037- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Synthesis and Biological Activity
- Intensive Care Unit Cognitive Disorders
- Diabetes Treatment and Management
- Flavonoids in Medical Research
- Biomedical Ethics and Regulation
- Medicinal Plant Pharmacodynamics Research
- Vitamin C and Antioxidants Research
- Bone health and osteoporosis research
- Clinical Nutrition and Gastroenterology
- Mesenchymal stem cell research
- Natural product bioactivities and synthesis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vitamin K Research Studies
- Neurological Disease Mechanisms and Treatments
- Biomarkers in Disease Mechanisms
- Foot and Ankle Surgery
- Cancer Cells and Metastasis
- Pregnancy-related medical research
- Water Treatment and Disinfection
- Marine Sponges and Natural Products
- Peripheral Artery Disease Management
- Axon Guidance and Neuronal Signaling
Dongguan People’s Hospital
2020-2025
Southern Medical University
2020-2025
Soochow University
2025
Harbin University of Science and Technology
2021-2023
Guangdong Medical College
2018-2022
Zunyi Medical University
2022
Guangdong Pharmaceutical University
2022
Marine Biomedical Research Institute of Qingdao
2019-2021
Songshan Lake Materials Laboratory
2018
Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than other derivatives. Currently, there are 20 marine-derived used in clinical practice, with 11 them demonstrating anti-tumor effects. This article provides a thorough review recent advancements exploration involving 167 bisindole their Not...
Kaempferol has been reported to exhibit beneficial effect on the osteogenic differentiation in mesenchymal stem cells (MSC) and osteoblasts. In our previous study, dexamethasone (DEX) demonstrated inhibitory MC3T3-E1 differentiation. this we mainly explored protective of kaempferol activity DEX osteogenesis cells. We found that ameliorated proliferation inhibition, cell cycle arrest, apoptosis increased alkaline phosphatase (ALP) mineralization DEX-treated also significantly enhanced...
Cancer stem cells (CSCs) are key drivers of cancer progression and therapeutic resistance. Long non-coding RNAs (lncRNAs) have emerged as critical regulators CSC properties. The aim this study was to investigate the role MIR4435-2HG in regulating characteristics, tumorigenesis, chemoresistance pancreatic cancer. Functional assays were conducted evaluate self-renewal, tumorigenic potential, with altered expression MIR4435-2HG. RNA interference (RNAi) employed knock down MIR4435-2HG, a STAT1...
Glucocorticoid (GC) therapy is the leading cause of secondary osteoporosis and therapeutic preventative drugs for GC-induced are limited. In this study, we investigated protective effects geniposide on dexamethasone (DEX)-induced osteogenic inhibition in MC3T3-E1 cells. The results showed that there was no obvious toxicity cells when used at doses ranging from 1 to 75 μM. DEX-treated cells, promoted alkaline phosphatase (ALP) activity mineralization. addition, also significantly increased...
Secondary osteoporosis is triggered mostly by glucocorticoid (GC) therapy. Dexamethasone (DEX) was reported to inhibit osteogenic differentiation in zebrafish larvae and MC3T3-E1 cells prior research. In this research, we primarily examined the protective impacts of epimedin C on inhibition impact mediated DEX. The findings illustrated no apparent toxicity for after administering at increasing dosages from 1 60 μM remarkable proliferation treated using that had been DEX, discovered enhanced...
Abstract Glucocorticoid‐induced osteoporosis is the third epidemic following postmenopausal and senileosteoporosis. According to one study, salidroside made ovariectomized rats' bones strong. Salidroside's potential for treating glucocorticoid‐induced remains unproven. This study aimed investigate protective effect mechanism of on dexamethasone‐induced osteogenic differentiation bone formation in MC3T3‐E1 cells zebrafish. The proved that salindroside had no harmful impact MC3T3E1 cells....
Abstract Pancreatic cancer is known for its recurrence and chemotherapy resistance, partly attributed to stem cells (CSCs). Targeting CSCs could improve the efficacy of standard cytotoxic therapies potentially prevent or delay recurrence. The increased reliance on modulation metabolic pathways in offers a potential therapeutic opportunity. In this study, we investigated effects CPI-613 (Dedvimistat), inhibitor that targets tricarboxylic acid cycle pancreatic cells. We demonstrate treatment...