A5079684666- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Computational Drug Discovery Methods
- Inflammasome and immune disorders
- Tannin, Tannase and Anticancer Activities
- Acute Kidney Injury Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Gout, Hyperuricemia, Uric Acid
- Extracellular vesicles in disease
- COVID-19 diagnosis using AI
- Analytical Chemistry and Chromatography
- Liver Diseases and Immunity
- Biomarkers in Disease Mechanisms
- Ideological and Political Education
- COVID-19 and Mental Health
- Hearing Impairment and Communication
- Immune responses and vaccinations
- IL-33, ST2, and ILC Pathways
- Hepatitis Viruses Studies and Epidemiology
- Synthesis and biological activity
- Astronomical Observations and Instrumentation
- COVID-19 epidemiological studies
- Educational Research and Pedagogy
- Viral Infections and Vectors
Union Hospital
2020-2023
Huazhong University of Science and Technology
2020-2023
Tongji University
2020-2022
State Council of the People's Republic of China
2020
Jiangmen Central Hospital
2013
Sun Yat-sen University
2013
Hengyang Academy of Agricultural Sciences
2002
Abstract Background Sepsis-associated AKI has been shown to be related sepsis mortality. Macrophage activation and endothelial cell damage are involved in the progression of sepsis-associated AKI, but specific mechanisms still unclear. Methods In vitro experiments, exosomes extracted from lipopolysaccharide (LPS) -stimulated macrophages were co-incubated with rat glomerular cells (RGECs) then detected injury markers RGECs. Acid sphingomyelinase (ASM) inhibitor amitriptyline used investigate...
Coronavirus disease 2019 (COVID-19) has been associated with increased mortality and morbidity from thromboembolism, especially venous thromboembolism. There are more limited data for systemic The present study aimed to investigate the prevalence of thromboembolism as well major bleeding in relation underlying risk factors impact anticoagulation use hospitalized patients COVID-19. Patients COVID-19 admitted Union Hospital, Wuhan, Hubei, China between January 08, 2020 April 7, were enrolled...
COVID-19 emerged in Wuhan December 2019 and soon became a worldwide pandemic. We collected analyzed the data from 1077 patients with who were admitted to west campus of Union Hospital January 16 April 16, 2020. Sixty (5.6%) diagnosed acute kidney injury (AKI) during hospitalization, 18 them (30%) had AKI on chronic disease (AKI/CKD). worse prognosis, higher intensive care unit (ICU) admission (28.3%) fatality (65%) rates than without (3.4% 10.7%, respectively). Among patients, was more...
Background: The pathological differences between Crohn’s disease (CD) and ulcerative colitis (UC) are substantial unexplained yet. Here, we aimed to identify potential regulators that drive different pathogenesis of CD UC by causal inference analysis transcriptome data. Methods: Kruskal–Wallis Dunnett’s tests were performed differentially expressed genes (DEGs) among patients, controls. Subsequently, pathways (DEPs) identified used construct the interaction network DEPs. Causal was IBD...
Background and Objective: WHO Director-General declared that the 2019-nCoV outbreak constitutes a Public Health Emergency of International Concern,and is still on-going.Chest CT had been key component diagnostic workup for patients with suspected infection. In this retrospective study, we attempt to summarize analyze chest features 2019-nCov infections, identify typical improved accuracy new coronavirus pneumonia (NCP). Methods: Chest scans Clinical data 21 confirmed NCP in our hospital were...
Fibrosis is a key component in the pathogenic mechanism of variety diseases. These diseases involving fibrosis may share common mechanisms and therapeutic targets, therefore intervention strategies medicines be applicable for these For this reason, deliberately introducing anti-fibrosis characteristics into predictive modeling lead to more success drug repositioning. In study, knowledge base was first built by collecting data from multiple resources. Both structural biological profiles were...
Objective To investigate the clinical value of serum procalcitonin (PCT) in diagnosis and treatment patients with high fever acute illness.Methods A total 285 febrile suffered from illness were divided into conventional group (n =122) PCT =163).The routine blood examination level C-reactive protein (CRP) detection carried out for dignosis these patiens two groups,and addition,serum determination was group.The comnfirmed by etiology or immunologic assays.Routine guidelines administrating...
At present, the prevention and control of COVID-19 is still severe, its pathogen SARS-CoV-2 highly infectious pathogenic, population generally susceptible. In order to deal with epidemic, selective operation can be postponed, but most patients acute abdominal diseases are commonly in clinic, onset severe condition, them accompanied fever gastrointestinal symptoms, so emergency needed.Under condition current epidemic—COVID-19, it requires a higher standard diagnose treat abdomen. The first...
Abstract Fibrosis is a key component in the pathogenic mechanism of many diseases. These diseases involving fibrosis may share common mechanisms, therapeutic targets and therefore, intervention strategies medicines be applicable for these For this reason, deliberately introducing anti-fibrosis characteristics into modelling lead to more success drug repositioning. In study, knowledge base was first built by collecting data from multiple resources. Both structural biological profiles were...
Objective: This study was designed to analyze the characteristics of novel coronavirus disease 2019 (COVID-19) epidemic in seven clusters city Chenzhou, China, act as a reference for prevention and control COVID-19 epidemic. Methods: The data confirmed cases reported between January 23 February 24, 2020, were obtained from Chenzhou infectious surveillance system. In line with diagnostic criteria Novel Coronavirus Pneumonia Diagnosis Treatment Plan (Sixth Edition, Trial Implementation), 33...