A5009906406- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Pluripotent Stem Cells Research
- Ion channel regulation and function
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- CAR-T cell therapy research
- Aortic Disease and Treatment Approaches
- Hematopoietic Stem Cell Transplantation
- Cardiac Arrhythmias and Treatments
- Optical Polarization and Ellipsometry
- Renal and related cancers
- Cardiovascular Function and Risk Factors
- Single-cell and spatial transcriptomics
- Leaf Properties and Growth Measurement
- Autopsy Techniques and Outcomes
- Infective Endocarditis Diagnosis and Management
- Peptidase Inhibition and Analysis
- Aortic aneurysm repair treatments
- Traumatic Brain Injury Research
- Dermatological and COVID-19 studies
Hohai University
2024
Sun Yat-sen University
2012-2024
Shanghai Pulmonary Hospital
2024
Tongji University
2024
Kunming Children's Hospital
2023
Key Laboratory of Guangdong Province
2023
Tsinghua University
2022
University Town of Shenzhen
2022
Chinese Academy of Sciences
2017-2019
Guangzhou Institutes of Biomedicine and Health
2015-2019
Autopsy is of great significance for elucidating the pathological changes, pathogenesis and cause death Coronavirus Disease 2019 (COVID-19) can provide a theoretical basis scientific accurate prevention control its outbreak. Based on related laws regulations, such as Law People's Republic China Prevention Control Infectious Diseases, clinical manifestations epidemiological characteristics COVID-19 guidelines this epidemic, combined with practical work forensic pathology examinations, we...
In the field of hematopoietic regeneration, deriving stem cells (HSCs) from pluripotent with engraftment potential is central mission. Unstable differentiation protocol due to variation factors such as serums and feeder cells, remains a major technical issue impeding screening key for derivation HSCs. combination cytokines, UM171 has capacity facilitate maintenance expansion human primary HSCs in vitro . Here, using serum-free, feeder-free, chemically defined induction protocol, we observed...
Sudden cardiac death (SCD) is progressively threatening the lives of young people throughout world. We conducted a retrospective study SCD cases identified among sudden based on comprehensive autopsies and pathological examinations in Center for Medicolegal Expertise Sun Yat-Sen University to investigate exact etiological distribution epidemiological features SCD. One thousand six hundred fifty-six were identified, accounted 43.0% these cases. The mean age cases—where data definite ages...
Thoracic aortic dissection (TAD) is the most common cause of sudden cardiac death associated with diseases. The age TAD victims in forensic studies significantly younger than hospitalized patients TAD, while only a few have been conducted on autopsy-diagnosed deceased. A retrospective study was at Medicolegal Center Sun Yat-sen University from 1999 to 2019 address characteristics victims. total 200 deceased spontaneous rupture were assessed, 165 (82.5%) males and 175 (87.5%) Stanford type...
Background This study aimed to employ plasma proteomics investigate the molecular changes, pathway alterations, and potential novel biochemical markers associated with balloon pulmonary angioplasty (BPA) in patients chronic thromboembolic hypertension (CTEPH). Methods Pre- post-BPA samples from five CTEPH PRACTICE were analyzed identify differentially expressed proteins. Proteomic bioinformatics analyses conducted, identified proteins further validated using ELISA assays a separate cohort of...
Abstract In vitro generation of hematopoietic stem cells from pluripotent (PSCs) can be regarded as novel therapeutic approaches for replacing bone marrow transplantation without immune rejection or graft versus host disease. To date, many different have been evaluated in terms directing PSCs toward cell types, yet, low efficiency and no function restrict the further differentiation study, our research aims to develop a three dimension (3D) approach that serves recapitulation embryonic...
Generating engraftable hematopoietic stem cells (HSCs) from pluripotent (PSCs) is an ideal approach for obtaining induced HSCs cell therapy. However, the path PSCs to robustly (iHSCs) in vitro remains elusive. We hypothesize that modification of niche by transcription factors facilitates derivation PSCs. The Lhx2 factor expressed fetal liver stromal but not blood cells. Knocking out leads a defect non-autonomous role. In this study, we demonstrate ectopic expression OP9 (OP9-Lhx2)...
Abstract Background Hypertrophic cardiomyopathy (HCM) is predominantly caused by mutations in sarcomeric genes. However, a subset of cases attributed to genetic disorders unrelated genes, such as Noonan syndrome (NS) and other RASopathies. In this study, we present family with history sudden cardiac death (SCD) focus on two adults syndromic left ventricular hypertrophy (LVH). Methods Clinical evaluations, including echocardiography, were conducted assess manifestations. Whole‐exome...
The expression of transcription factor Hoxb5 specifically marks the functional haematopoietic stem cells (HSC) in mice. However, our recent work demonstrated that ectopic exerted little effect on HSC but could convert B-cell progenitors into T vivo. Thus, cell type- and development stage-specific roles hierarchy await more extensive exploration. In this study, we aim to investigate multipotent blood progenitor cells.A Mx1cre/RosaLSL-Hoxb5-EGFP/+ mouse model was used evaluate (MPP). Golden...
Hoxb5 exhibits preferential expression in hematopoietic stem cells (HSCs) and uniquely marks the long-term HSCs (LT-HSCs). Previous studies have demonstrated remarkable capability of to alter cell fates when enforced blood progenitors, such as B progenitors multipotent progenitors. Additionally, deficiency does not hinder generation LT-HSCs. However, specific impact deletion on LT-HSCs has remained unexplored. To address this, we developed a conditional knockout-reporter mouse model, wherein...
As a substitute for scalp needle, the intravenous indwelling needle is easy to operate and use. it not only conducive rescue of critically ill children, improves nursing efficiency, but also avoids pain caused by repeated venipuncture. However, cases catheter breaking remaining in vessels are rarely reported. This study collected 12 vein rupture retention our center from January 2012 2022. It was found that there were 7 males 5 females, with an average age 19.17 ± 8.96 months. The length...
Background Mitral annular disjunction (MAD) is an under-recognised phenotype associated with severe ventricular arrhythmias. Limited knowledge has been gained on its molecular genesis. Methods A total of 150 unrelated deceased Chinese were collected for whole-exome sequencing, analysis focusing a panel 118 genes ‘abnormal mitral valve morphology’. Cases prespecified as ‘longitudinally extensive MAD (LE-MAD)’ or less-extensive (LLE-MAD)’ according to the gross disjunctional length cut-off 4.0...
Producing qualified forensic pathological practitioners is a common difficulty around the world. In China, pathology one of required major subspecialties for undergraduates majoring in medicine, contrast to education Western countries where often optional. The enduring predicament that professional qualities and abilities students from different institutions vary due lack an efficient pedagogical model. purpose this article describe new model at Zhongshan School Medicine, Sun Yat-sen...
Abstract Sudden unexplained nocturnal death syndrome (SUNDS) is widely considered to be related hereditary fatal arrhythmias. Hyperpolarization‐activated cyclic nucleotide‐gated channel 4 (HCN4) channels are distributed in sinus myocytes and play a profound role generating pacemaker electro‐activity cardiomyocytes. In the present study, potential correlation between HCN4 gene variations occurrence of SUNDS was investigated. Genomic DNA extracted from blood samples both 119 unrelated patients...
The accuracy of the Mueller polarimeter is usually affected by Gaussian–Poisson mixed noise, and optimizing instrument matrices polarization state generator analyzer in measurement system, estimation variance caused Gaussian noise can be suppressed, Poisson made independent sample. However, optimization procedure targets only numerical value matrix without considering how to configure system achieve optimal matrix. In this paper, we investigate make for different systems combining geometric...