A5031474236- Microbial Inactivation Methods
- Optical Network Technologies
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- High-Voltage Power Transmission Systems
- Cardiac electrophysiology and arrhythmias
- Power Systems and Technologies
- Microfluidic and Bio-sensing Technologies
- Smart Grid and Power Systems
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Immune cells in cancer
- Advanced Photonic Communication Systems
- Spinal Cord Injury Research
- Power Systems and Renewable Energy
- Medical Malpractice and Liability Issues
- Medical Research and Treatments
- Respiratory Support and Mechanisms
- Advanced Fiber Optic Sensors
- Photonic Crystal and Fiber Optics
- Power Systems Fault Detection
- Reproductive System and Pregnancy
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
Shenzhen University
2024-2025
Inner Mongolia Medical University
2024
University of Wisconsin–Madison
2021-2024
Nanjing University of Chinese Medicine
2024
Beijing Jiaotong University
2020-2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Beijing Chuiyangliu Hospital
2024
Jiangsu Province Hospital
2024
General Hospital of Shenyang Military Region
2015-2022
A body of experimental evidence suggests that T cells mediate neuroprotection following CNS injury; however, the antigen specificity these and how they are unknown. Here, we have provided cell–mediated after injury can occur independently major histocompatibility class II (MHCII) signaling to cell receptors (TCRs). Using two murine models injury, determined damage-associated molecular mediators originate from injured tissue induce a population neuroprotective, IL-4–producing in an...
The inflammatory response following spinal cord injury (SCI) involves the activation of resident microglia and infiltration macrophages. Macrophages can be polarized into classically activated proinflammatory M1 phenotype or alternatively anti-inflammatory M2 phenotype. Programmed cell death 1 (PD-1) is a critical immune inhibitory receptor involved in innate adaptive responses. However, whether PD-1 modulation macrophage/microglial polarization unknown. In this study, mRNA levels pd1...
Abstract Previous research investigating the roles of T effector (Teff) and regulatory (Treg) cells after injury to CNS has yielded contradictory conclusions, with both protective destructive functions being ascribed each these cell subpopulations. In this work, we study dichotomy by examining how regulation immune system affects response trauma. We show that, in injury, Teff Treg subsets CNS-draining deep cervical lymph nodes are activated, surgical resection results impaired neuronal...
<h3>BACKGROUND:</h3> Despite the high prevalence of weight loss in subjects with COPD, 2011 COPD management guidelines do not include an index measuring nutritional status. Fat-free mass (FFMI) can accurately determine status and may be closely correlated severity. We aimed to evaluated by FFMI according Global Initiative for Chronic Obstructive Lung Disease (GOLD) levels stable association between respiratory symptoms, exercise capacity, muscle function. <h3>METHODS:</h3> included 235 this...
Background Esophageal ulceration and fistula are severe complications of pulmonary vein isolation using thermal ablation. Nonthermal irreversible electroporation (NTIRE) is a promising new technology for in patients with atrial fibrillation. NTIRE ablation has been used to treat fibrillation; however, the effects on esophageal tissue have not clearly described. Methods Results A typical electrical protocol was directly applied esophagi 84 New Zealand rabbits. Finite element modeling...
Spinal cord injury (SCI) frequently provokes serious detrimental outcomes because neuronal regeneration is limited in the central nervous system (CNS). Thus, creation of a permissive environment for transplantation therapy with neural stem/progenitor cells (NS/PCs) promising strategy to replace lost cells, promote repair, and stimulate functional plasticity after SCI. Macrophages are important SCI-associated inflammatory major source secreted factors that modify lesion milieu. Here, we used...
A step index few-mode erbium-doped fiber (FM-EDF) for mode gain equalization is designed and proposed in this paper, which uses the layered-doping method to reduce differential (DMG). The optimum structure of FM-EDF obtained by adjusting doping radius concentration. When applied a amplifier (FM-EDFA), DMG range 1550-1565 nm ∼0.28dB, whole C-band usually less than 0.5 dB. At same time, each 1530-1555 ∼20dB, while decreases gradually 1555-1565 due absorption characteristics erbium ions. In...
Abstract O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is a critical post-translational (PTM) of cytoplasmic and nuclear proteins. O-GlcNAcylation levels are regulated by the activity two enzymes, O-GlcNAc transferase (OGT) O‑GlcNAcase (OGA). While OGT attaches to proteins, OGA removes from Since its discovery, researchers have demonstrated on thousands proteins implicated in numerous different biological processes. Moreover, dysregulation has been associated...
Irreversible electroporation (IRE) is a novel ablation method that has been tested in humans with lung, prostate, kidney, liver, lymph node and presacral cancers. As new non-thermal treatment, the use of IRE to ablate tumors musculoskeletal system might reduce incidence fractures. We aimed determine threshold cortical bone evaluate medium- long-term healing process mechanical properties femur rabbit model post-IRE ablation. The was between 1090 V/cm 1310 (120 pulses). IRE-ablated femurs...
Cardiopulmonary bypass (CPB) is mainly used during cardiac surgeries that treat ischemic, valvular, or congenital heart disease and aortic dissections. The disorders of central nervous system (CNS) occur after cardiopulmonary are attracting considerable interest. Postoperative neurocognitive (PND) have been reported as the leading cause patients’ disability death following CPB. k-opioid receptor (KOR) agonists (U50488H) suggested to be vital in treatment surgically induced CNS...
Abstract Background When using ablation technology to treat esophageal cancer or tumors adjacent the esophagus, damage and recovery of esophagus itself is particular concern. Non-thermal irreversible electroporation (NTIRE) a novel minimally invasive method that uses microsecond electric fields create nanoscale defects on cell membranes induce death, while keeping all other molecules (including extracellular matrix) intact. In this study, we aimed study effect NTIRE wall its subsequent...
Abstract Rationale: Acquired cystic disease-associated renal cell carcinoma (ACKD-RCC) is a unique subtype of (RCC) and found exclusively in patients with end-stage disease. We report case intracapsular nephrectomy (ICAN) allograft ACKD-RCC. To our knowledge, this the first Asia ICAN to treat Patient concerns: A 51-year-old male patient history allogeneic kidney transplantation (23 years previously) presented degeneration transplanted over past 2 years. Diagnoses: was used remove kidney....
The atrial myocardium demonstrates the highly heterogeneous organization of transversal-axial tubule system (TATS), although its anatomical distribution and region-specific impact on Ca2+ dynamics remain unknown. Here, we developed a novel method for high-resolution confocal imaging TATS in intact live mouse applied custom-developed MATLAB-based computational algorithm automated analysis integrity. We observed twofold higher (P < 0.01) density right appendage (RAA) than intercaval regions...
Background To evaluate the potential effects of irreversible electroporation ablation on Achilles tendon in a rabbit model and to compare histopathological biomechanical changes between specimens following radiofrequency ablation. Methods A total 140 six-month-old male New Zealand rabbits were used. The animals randomly divided into two groups, 70 group group. In situ ablations applied directly tendons using typical (1800 V/cm, 90 pulses) (power control mode) protocols. Histopathological...
Acupuncture is a method for treating tic disorder. However, there lack of sufficient clinical objective basis in regards its treatment efficacy. Indeed, are structural abnormalities present energy metabolism and infrared thermography children with Therefore, this study proposes trial scheme to explore the possible mechanism acupuncture