A5086203171- Cancer, Stress, Anesthesia, and Immune Response
- Nicotinic Acetylcholine Receptors Study
- Anesthesia and Neurotoxicity Research
- Neuropeptides and Animal Physiology
- Intensive Care Unit Cognitive Disorders
Anshan Hospital
2021
Jinzhou Medical University
2019
Cardiopulmonary bypass (CPB) is mainly used during cardiac surgeries that treat ischemic, valvular, or congenital heart disease and aortic dissections. The disorders of central nervous system (CNS) occur after cardiopulmonary are attracting considerable interest. Postoperative neurocognitive (PND) have been reported as the leading cause patients’ disability death following CPB. k-opioid receptor (KOR) agonists (U50488H) suggested to be vital in treatment surgically induced CNS...
Objective To evaluate the effect of α7 nicotinic acetylcholine receptor (α7nAChR) agonist on inflammasome NOD-like pyrin domain containing 3 (NLRP3) during brain injury induced by cardiopulmonary bypass (CPB) in rats. Methods Twenty-four clean-grade adult male Sprague-Dawley rats, weighing 350-450 g, were randomly divided into sham operation group (group S), CPB, and CPB plus α7nAChR PHA568487 CP) after 5-day Morris water maze training, with 8 rats each group.Group S was mechanically...