A5100386520- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- Adipokines, Inflammation, and Metabolic Diseases
- Spinal Cord Injury Research
- Heart Rate Variability and Autonomic Control
- Pharmacological Effects of Natural Compounds
- Adipose Tissue and Metabolism
- Food Quality and Safety Studies
- Curcumin's Biomedical Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Aldose Reductase and Taurine
- Chemotherapy-induced organ toxicity mitigation
- Neurological Disorders and Treatments
- Adenosine and Purinergic Signaling
- Nanoparticles: synthesis and applications
- Sleep and related disorders
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Heavy Metal Exposure and Toxicity
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
Southwest Minzu University
2023-2025
South China Normal University
2025
Central Hospital of Wuhan
2018-2024
Huazhong University of Science and Technology
2015-2024
Air Force Medical University
2014-2023
North Sichuan Medical University
2023
Jilin City Central Hospital
2023
Ludwig-Maximilians-Universität München
2019-2022
Nanjing Medical University
2022
Women's Hospital
2022
Although cisplatin-based chemotherapy has been used as the first-line treatment for ovarian cancer (OC), tumor cells develop resistance to cisplatin during treatment, causing poor prognosis in OC patients. Studies have demonstrated that overactivation of phosphatidylinositol 3-kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) pathway is involved chemoresistance and overexpression microRNA-497 (miR497) may overcome by inhibiting mTOR pathway. However, low transcriptional...
Inter-organelle communication coordinates cellular homeostasis and function. Juvenile hormone (JH) is produced in the corpora allata (CA) acts as a gonadotrophic most insects. Using transcriptomic, biochemical, molecular, genetic analyses, here we investigated underlying mechanism of how inter-organelle dynamically orchestrates JH biosynthesis female reproduction American cockroach, Periplaneta americana. The extracellular stimuli insulin allatostatin act through their membrane receptors...
Abstract Background Coronavirus disease 2019 (COVID-19) triggered by infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been widely pandemic all over the world. The aim of this study was to analyze influence factors death risk among 200 COVID-19 patients. Methods Two hundred patients confirmed SARS-CoV-2 were recruited. Demographic data and clinical characteristics collected from electronic medical records. Biochemical indexes on admission measured patient’s...
Single atom catalysts (SACs) have recently attracted great attention in heterogeneous catalysis and been regarded as ideal models for investigating the strong interaction between metal support. Despite huge progress over past decade, deep understanding on structure-performance correlation of SACs at a single level still remains to be challenge. In this study, we demonstrate that variation coordination number Pt can significantly promote propylene selectivity during propyne semihydrogenation...
The aim of the present study was to explore role oxidative stress in liver toxicity induced by nickel oxide nanoparticles (nano‑NiO) rats. Male Wistar rats received saline (control), nano‑NiO [0.015, 0.06 or 0.24 mg/kg body weight (b.w.)] micro‑NiO (0.24 b.w.) intratracheal instilling twice a week for 6 weeks. Liver tissues were then collected and examined biomarkers nitrative stress, as well mRNA expression heme oxygenase (HO)‑1 metallothionein (MT)‑1. results demonstrated that NiO exposure...
Nickel can induce apoptosis of testicular Leydig cells in mice, whereas the mechanisms remain unclear. In this study, we investigated role nickel-induced reactive oxygen species (ROS) generation mitochondria and endoplasmic reticulum stress (ERS) mediated pathways rat cells. Fluorescent DCF Annexin-V FITC/PI staining were performed to measure production ROS RT-qPCR Western blot conducted analyze key genes proteins involved ERS apoptotic pathways. The results showed that nickel sulfate...
Sleep deprivation (SD) significantly disrupts the homeostasis of cardiac-brain axis, yet neuromodulation effects deep magnetic stimulation (DMS), a non-invasive and safe method, remain poorly understood. Sixty healthy adult males were recruited for 36-h SD study, they assigned to DMS group or control according their individual willing. All individuals underwent heart sound measurements functional resonance imaging scans at experiment's onset terminal points. During recovery sleep phase, was...
The ethanol extracts from leaf, roasted cortex, and seed of Du-zhong (Eucommia ulmoides Oliv.) were examined for total phenolics content (TPC) flavonoids (TFC). antioxidant activity the was evaluated by measuring radical scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing power (FRAP), lipid peroxidation inhibition capacity in a β-carotene/linoleic acid system. leaf extract found to have highest TPC (94.46 ± 1.17 mg gallic equiv/g solid extract) TFC (61.36 0.59 catechin...
Phosgene gas is a lower respiratory tract irritant. As such, it stimulates nociceptive vagal C-fiber-related reflexes in dose-rate and concentration × exposure duration (C t)-dependent manner. In rats, this reflex characterized by extended apnea time periods, bradycardia, hypothermia. Although inhalation exposures at nonlethal C t products show rapid reversibility of reflexively induced changes patterns, lethal seem to cause prolonged stimulation after discontinued phosgene. This observation...
This study aimed to explore the role of NF-κB signaling pathway in rat liver toxicity after nano NiO exposure.
Cisplatin (CIS) is widely applied for its antihematological malignancies properties and as antisolid tumors drugs. However, it could cause testicular damage related with oxidative stress testosterone synthesis disorder. Studies reported that grape seed procyanidins extract (GSPE) improve CIS induced-testes lesion via scavenging free radicals in animals, although mechanisms were unclear. Therefore, the purpose of present study was to explore antagonistic GSPE on CIS-induced testes lesion....
ABSTRACT With the progress of nanotechnology, nano nickel oxide (NiO) has been extensively used as sensors, battery electrodes, catalysts, and cosmetics. Previous researches verified that NiO could exert pulmonary toxicity, but its mechanism was unclear. To shed light upon this, role nuclear factor‐ κ B (NF‐ B) activation Th1/Th2 imbalance were to explore in damage induced by NiO. Male Wistar rats randomized into control group, groups (0.015, 0.06, 0.24 mg kg −1 ) micro group (0.024 treated...
Background: Along with increased usage of continuous glucose monitors, flash and patch pumps by patients diabetes, the frequency skin reactions has also increased. Skin irritation itching can be annoying to users. However, more serious contact allergies one or components adhesives plastic material housing devices become lifelong. Redness itchiness are so strong that no longer use a particular system. In August 2017, major culprit allergen, isobornyl acrylate (IBOA), was identified for these...
Nickel oxide nanoparticles (nano NiO) could induce hepatocyte apoptosis, while its potential mechanisms are unclear. This study aimed to explore the role of endoplasmic reticulum (ER) stress pathways in apoptosis induced by nano NiO. Male Wistar rats were administrated with NiO (0.015, 0.06, and 0.24 mg/kg b.w.) micro (0.24 intratracheal instillation twice a week for 6 weeks. We measured levels TdT-mediated dUTP nick-end labeling (TUNEL) staining, ER related gene protein expression rat...
Abstract Background Neuropathic pain is a debilitating status that insusceptible to the existing analgesics. It important explore underlying pathophysiological changes and search for new pharmacological approaches. Transient receptor potential canonical 6 (TRPC6) mechanosensitive channel expressed by dorsal root ganglia glial cells. has been demonstrated this in plays essential roles formation of mechanical hyperalgesia neuropathic pain. Recent screening suggests larixyl acetate (LA), main...
Spinal cord injury (SCI) frequently provokes serious detrimental outcomes because neuronal regeneration is limited in the central nervous system (CNS). Thus, creation of a permissive environment for transplantation therapy with neural stem/progenitor cells (NS/PCs) promising strategy to replace lost cells, promote repair, and stimulate functional plasticity after SCI. Macrophages are important SCI-associated inflammatory major source secreted factors that modify lesion milieu. Here, we used...
Background/Aims: It has been implicated that calcium supplementation is involved in reducing body weight/fat and improving glucose homeostasis. However, the underlying mechanisms are still not fully understood. Here, we investigated effects of on adipogenesis homeostasis porcine bone marrow mesenchymal stem cells (pBMSCs) high fat diet (HFD)-fed mice explored signaling pathways. Methods: In vitro, pBMSCs were treated with 4 mM extracellular ([Ca2+]o) and/or 1 μM nifedipine, 0.1 BAPTA-AM,...