Neurotoxicity can cause a range of symptoms and disorders in humans, including neurodegenerative diseases, neurodevelopmental disorders, nerve conduction abnormalities, neuroinflammation, autoimmune cognitive deficits. The cyclic guanosine-adenosine synthase (cGAS)-stimulator interferon genes (STING) pathway NF-κB are two important signaling pathways involved the innate immune response. cGAS-STING is activated by recognition intracellular DNA, which triggers production type I interferons...

Abstract The paper is aimed to investigate the toxicity of nano-TiO 2 and its potential harmful impact on human health using meta-analysis in vitro short-time animal studies. Data were retrieved according included excluded criteria from 1994 2011. combined toxic effects calculated by different endpoints cell models. From analysis experimental studies, more than 50% showed positive statistical significance except apoptosis group, cytotoxicity was a dose-dependent but not clear size-dependent...

The content of wheat flour proteins affects the quality flour. Sulfur nutrition in can change protein inconsistency and instability grain during filling under high temperature stress (HTS) are a major challenge to production high-quality wheat. effects sulfur fertilization HTS on its components unknown. In this study, treatments varying two factors: exposure short-term HTS, at 20 days post-anthesis, were applied cultivars with differing gluten types. Plants strong-gluten (Gaoyou 2018)...

One of the key mechanisms alcoholic liver disease is oxidative stress. Both Curcumin and Baicalin exert antioxidant effects, but mechanism their combined effects ethanol-induced injury still unclear. This study was conducted to evaluate dual activity with against in rats. Rats were divided into five groups, a control, ethanol, ethanol + (50 mg/kg), +Baicalin group ten rats per group. The on enzymes, stress indicators levels Nrf2/HO-1 pathway related proteins mRNA observed along...

Abstract Nickel oxide nanoparticles (Nano NiO) bears hepatotoxicity, while whether it leads to liver fibrosis remains unclear. The aim of this study was establish the Nano NiO‐induced hepatic model in vivo and investigate roles transforming growth factor β1 (TGF‐β1) Smad pathway activation, epithelial‐mesenchymal transition (EMT) occurrence, extracellular matrix (ECM) deposition vitro. Male Wistar rats were exposed 0.015, 0.06, 0.24 mg/kg NiO by intratracheal instilling twice a week for 9...

The aim of the present study was to explore role oxidative stress in liver toxicity induced by nickel oxide nanoparticles (nano‑NiO) rats. Male Wistar rats received saline (control), nano‑NiO [0.015, 0.06 or 0.24 mg/kg body weight (b.w.)] micro‑NiO (0.24 b.w.) intratracheal instilling twice a week for 6 weeks. Liver tissues were then collected and examined biomarkers nitrative stress, as well mRNA expression heme oxygenase (HO)‑1 metallothionein (MT)‑1. results demonstrated that NiO exposure...

Improving radiation use efficiency (RUE) of the canopy is necessary to increase wheat (Triticum aestivum) production. Tridimensional uniform sowing (U) technology has previously been used construct a uniformly distributed population structure that increases RUE. In this study, we tridimensional create within which light was spread evenly This study done during 2014–2016 in Shunyi District, Beijing, China. The soil type sandy loam. Wheat grown two patterns: (1) (U); (2) conventional drilling...

Nickel can induce apoptosis of testicular Leydig cells in mice, whereas the mechanisms remain unclear. In this study, we investigated role nickel-induced reactive oxygen species (ROS) generation mitochondria and endoplasmic reticulum stress (ERS) mediated pathways rat cells. Fluorescent DCF Annexin-V FITC/PI staining were performed to measure production ROS RT-qPCR Western blot conducted analyze key genes proteins involved ERS apoptotic pathways. The results showed that nickel sulfate...

The potential immune effects of titanium dioxide nanoparticles (nano-TiO2) are raising concern. Our previous study verified that nano-TiO2 induce local response in lung tissue followed by intratracheal instillation administration. In this study, we aim to evaluate the systemic nano-TiO2. Sprague Dawley rats were treated with at doses 0.5, 4, and 32 mg/kg body weight, micro-TiO2 weight 0.9% NaCl, respectively. exposure was conducted twice a week, for four consecutive weeks. Histopathological...

This study aimed to explore the role of NF-κB signaling pathway in rat liver toxicity after nano NiO exposure.

Cisplatin (CIS) is widely applied for its antihematological malignancies properties and as antisolid tumors drugs. However, it could cause testicular damage related with oxidative stress testosterone synthesis disorder. Studies reported that grape seed procyanidins extract (GSPE) improve CIS induced-testes lesion via scavenging free radicals in animals, although mechanisms were unclear. Therefore, the purpose of present study was to explore antagonistic GSPE on CIS-induced testes lesion....

Abstract Nickel oxide nanoparticles (NiO NPs) causes pulmonary fibrosis via activating transforming growth factor‐β1 (TGF‐β1) in rats, but its upstream regulatory mechanisms are unknown. This study aimed to explore the role of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) NiO NPs‐induced collagen deposition. Male Wistar rats were intratracheally instilled with NPs (0.015, 0.06, and 0.24 mg/kg b.w.) twice a week for 9 weeks. Human lung adenocarcinoma epithelial cells (A549...

Nickel oxide nanoparticles (NiONPs) are toxic heavy metal compounds that induce liver fibrosis and metabolic disorders. Current research shows the intestinal microbiota regulates metabolism through gut-liver axis. However, it is unclear whether NiONPs affect relationship between Therefore, in this study, we established model by administering 0.015, 0.06 0.24 mg/mL tracheal instillation twice a week for 9 weeks rats, then collected serum fecal sample whole metabolomics metagenomic sequencing....

Nickel oxide nanoparticles (NiONPs) can induce liver fibrosis, and their mechanism may be related to non-coding RNA, nuclear receptor signal transduction ferroptosis, but the regulatory relationship between them is not clear. In this study, we aimed investigate role of hsa_circ_0001944 in regulating Farnesol X (FXR)/Toll-like 4 (TLR4) pathway ferroptosis NiONPs-induced collagen deposition. We observed decreased FXR expression, increased TLR4 expression alterations features both rat fibrosis...

Nickel oxide nanoparticles (nano NiO) could induce hepatocyte apoptosis, while its potential mechanisms are unclear. This study aimed to explore the role of endoplasmic reticulum (ER) stress pathways in apoptosis induced by nano NiO. Male Wistar rats were administrated with NiO (0.015, 0.06, and 0.24 mg/kg b.w.) micro (0.24 intratracheal instillation twice a week for 6 weeks. We measured levels TdT-mediated dUTP nick-end labeling (TUNEL) staining, ER related gene protein expression rat...

ABSTRACT With the progress of nanotechnology, nano nickel oxide (NiO) has been extensively used as sensors, battery electrodes, catalysts, and cosmetics. Previous researches verified that NiO could exert pulmonary toxicity, but its mechanism was unclear. To shed light upon this, role nuclear factor‐ κ B (NF‐ B) activation Th1/Th2 imbalance were to explore in damage induced by NiO. Male Wistar rats randomized into control group, groups (0.015, 0.06, 0.24 mg kg −1 ) micro group (0.024 treated...

Content of wheat flour proteins affects the quality flour. Zinc nutrition in can change protein content The inconsistency and instability grain during filling while under high temperature stress (HTS) are major problems production wheat. At present, there is a lack studies on zinc fertilizer HTS effects its components. For this study, treatment combinations four levels fertilizers exposure to short-term HTS, at 20 d after flowering (D20), were tested two cultivars with different gluten...

Nitrogen (N) supplementation is essential to the yield and quality of bread wheat ( Triticum aestivum L.). The impact N-deficiency on at seedling stage has been previously reported, but distinct N regimes applied with continuous application filling maturing grains lesser known, despite being critical for final grain flour quality. Here, we compared phenotype characteristics such as yield, protein sugar quality, plant growth, leaf photosynthesis under N-deficient N-sufficient conditions...

With the widespread use of manganese dioxide nanoparticles (nano MnO 2 ), health hazards have also emerged. The inflammatory damage brain tissues could result from nano , in which underlying mechanism is still unclear. During this study, we aimed to investigate role ROS-mediated p38 MAPK pathway -induced response BV2 microglial cells. injury model was established by treating cells with 2.5, 5.0, and 10.0 μg/mL suspensions for 12 h. Then, reactive oxygen species (ROS) scavenger (20 nM...