A5033520032- Ion channel regulation and function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Heart Rate Variability and Autonomic Control
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Sleep and Work-Related Fatigue
- Sleep and related disorders
- Ion Transport and Channel Regulation
- Pancreatic and Hepatic Oncology Research
- Nicotinic Acetylcholine Receptors Study
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Hemispheric Asymmetry in Neuroscience
- Nerve injury and regeneration
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Nanoparticle-Based Drug Delivery
- Signaling Pathways in Disease
- ATP Synthase and ATPases Research
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2018-2025
Institute of Physiology and Basic Medicine
2022-2023
Chengdu Medical College
2022-2023
Beijing Institute of Education
2021-2023
Shandong University
2023
Beijing Sport University
2022
Southwest Minzu University
2022
Academy of Military Medical Sciences
2007-2018
Beijing Proteome Research Center
2015-2018
State Key Laboratory of Proteomics
2015
Inflammatory pain hypersensitivity results partly from hyperexcitability of nociceptive (damage-sensing) dorsal root ganglion (DRG) neurons innervating inflamed tissue. However, most the evidence for this is derived experiments using acute inflammatory states. Herein, we used several approaches to examine impact chronic or persistent inflammation on excitability DRG and their expression I(h) underlying hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which regulate...
Sleep deprivation (SD) significantly disrupts the homeostasis of cardiac-brain axis, yet neuromodulation effects deep magnetic stimulation (DMS), a non-invasive and safe method, remain poorly understood. Sixty healthy adult males were recruited for 36-h SD study, they assigned to DMS group or control according their individual willing. All individuals underwent heart sound measurements functional resonance imaging scans at experiment's onset terminal points. During recovery sleep phase, was...
The abnormal amyloid β (Aβ) accumulation and Aβ-related neural network dysfunction are considered central to the pathogenesis of Alzheimer's disease (AD) at early stage. Deep-brain reachable low field magnetic stimulation (DMS), a novel noninvasive approach that was designed intervene activity in brains, has been found alleviate stress-related cognitive impairments.Amyloid precursor protein/presenilin-1 transgenic mice (5XFAD) were treated with DMS, behavior AD-like pathologic changes...
Excellent response inhibition is the basis for outstanding competitive athletic performance, and sleep may be an important factor affecting athletes' inhibition. This study investigates effect of deprivation on inhibition, its differentiating non-athlete controls' with aim helping athletes effectively improve their ability through pattern manipulation. Behavioral event-related potential (ERP) data were collected from 36 participants (16 table tennis 20 general college students) after h using...
Background: Previous studies revealed that sleep deprivation (SD) impairs risk perception and leads to poor decision-making efficiency. However, how is related brain regions’ communication after SD has not been elucidated. In this study, we investigated the neuropsychological mechanisms of SD-impaired perception. Methods: Nineteen healthy male adults were recruited underwent resting-state functional magnetic resonance imaging during a state rested wakefulness nearly 36 h total SD. They then...
The present study aimed to compare the clinical effects of vitamin E and D on a rat model dextran sulfate sodium (DSS)‑induced ulcerative colitis (UC), elucidate underlying mechanisms associated with changes in levels cytokines. After successful establishment DSS‑induced UC, prednisolone (1 mg/kg), (50 ng) (6, 30 150 IU/kg) were orally administered for 1 week. pharmacodynamics evaluated by daily combination observation (CO) scores, histopathological evaluations assessment molecular markers...
The acute ischemic stroke (AIS) impacts extensively all over the world, early diagnosis can provide valuable property information of disease. However, it's difficult for our human eyes to distinguish fine pathological changes. Here we introduce self-attention mechanisms and propose UCATR, an NCCT image segmentation network AIS lesions. It uses advantages Transformer effectively learn global context features image, is based on convolutional neural (CNN) as encoder, adding Multi-Head...
Morphine is an opioid commonly used to treat pain in clinic, but it also has the potential be highly addictive, which can lead abuse. Despite these known risks, cellular and molecular mechanism of morphine conditioned place preference (CPP) still unclear. In this study, using a rat model chronic administration, we found that compared with control group, mRNA protein expression HCN2 channel ventral tegmental area (VTA) were upregulated. Further immunofluorescence analysis showed fluorescence...
Abstract Peripheral neuropathic pain associated with partial nerve injury is believed to be driven partly by aberrant spontaneous activity (SA) in both injured and uninjured dorsal root ganglion (DRG) neurons. The underlying ionic mechanisms are not fully understood, but hyperpolarization-activated cyclic nucleotide–gated (HCN) channels which underlie the excitatory I h current have been implicated SA generation axotomized A-fiber neurons after L5-spinal ligation/axotomy (SNL/SNA). Here,...
Ventral tegmental area (VTA) dopamine system plays an important role in depression and is also involved pain experience. In this study, we investigated the VTA dopaminergic (DA) neuron firing local field potential (LFP) pain-related depression, try to explore underlying relationship between depression.We used neuropathic model [spare nerve injury (SNI)] induce depression. The Dixon up-down method was test mechanical hypersensitivity. Behavioral changes like open test, sucrose preference...
Spatial cognition facilitates the successful completion of specific cognitive tasks through lateral processing and neuroplasticity. Long-term training in table tennis induces neural efficiency visuospatial cortex athletes. However, lateralization characteristics mechanisms visual−spatial players non-sport domains are unclear. This study utilized event-related potentials to investigate differences spatial abilities regular college students (controls) players. A total 48 participants (28...
Abstract Myocardial infarction accompanied by diabetes mellitus is accepted as the most serious type of coronary heart disease, and among current treatment strategies, precise delivery protective drugs for inhibiting cardiomyocyte apoptosis still a challenge. In this study, we developed biodegradable nanoparticles‐based system with excellent macrophage escape, cardiac targeting, drug release properties to achieve targeted therapy myocardial infarction. Specifically, copolymer p(DMA–MPC–CD)...
Abstract Repetitive transcranial magnetic stimulation (rTMS) is an increasingly common technique used to selectively modify neural excitability and plasticity. There still controversy concerning the cortical response rTMS of different frequencies. In this study, a novel in vitro paradigm utilizing Multi-Electrodes Array (MEA) system acute cerebellar slicing described. controllable environment that comprises perfusion, incubation, recording modules, spontaneous single-unit spiking activity...
Abstract Background Patients with acute large vessel occlusion (LVO) presenting minor stroke are at risk of early neurological deterioration (END). The present study aimed to evaluate the frequency and potential predictors END in patients medical management LVO stroke. relationship between SVS length was also investigated. Methods This a prospective multicenter study. Consecutive were collected anterior circulation. presented [National Institutes Health Stroke Scale (NIHSS) ≤ 4] within 24 h...