A5100687837- Cancer-related molecular mechanisms research
- Peanut Plant Research Studies
- Renal cell carcinoma treatment
- RNA modifications and cancer
- FOXO transcription factor regulation
- Organ Transplantation Techniques and Outcomes
- Ferroptosis and cancer prognosis
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Renal Transplantation Outcomes and Treatments
- RNA Research and Splicing
- Enterobacteriaceae and Cronobacter Research
- Mesenchymal stem cell research
- Single-cell and spatial transcriptomics
- Peptidase Inhibition and Analysis
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Cancer Mechanisms and Therapy
- Renal and Vascular Pathologies
- Cardiac tumors and thrombi
- Nitrogen and Sulfur Effects on Brassica
- Coconut Research and Applications
- Epigenetics and DNA Methylation
- Brucella: diagnosis, epidemiology, treatment
- Lung Cancer Diagnosis and Treatment
Zhejiang University
2023-2025
University of Chinese Academy of Sciences
2021-2024
Shanghai Institute of Nutrition and Health
2020-2024
Suizhou Central Hospital
2013-2024
Guangzhou Medical University
2012-2024
Second Affiliated Hospital of Guangzhou Medical University
2012-2024
Air Force Medical University
2024
Xijing Hospital
2024
Jiaxing University
2022-2024
Yuhuangding Hospital
2015-2024
The deleterious side effects of calcineurin inhibitors have impaired long-term survival after renal allograft. New immunotherapy regimens that minimize or even eliminate are required to improve transplantation outcome. Mesenchymal stem cells (MSCs) represent a unique cell population with immunosuppressive function and prolong allograft in experimental organ transplant models.In this pilot study, donor-derived bone marrow MSCs combined sparing dose tacrolimus (50% standard dose) were...
Previous study demonstrated that extracellular ATP could promote cell migration and invasion in multiple human cancers. Till now, the pro-invasive mechanisms of P2RX6, a preferred receptor for ATP, are still poorly studied RCC.Bioinformatics analysis was performed to identify differentially expressed genes during RCC different stages. Tissue microarray, IHC staining survival respectively used evaluate potential clinical function. In vitro vivo assays were explore P2RX6 biological effects...
The aberrant expression of long noncoding RNAs (lncRNAs) has recently emerged as key molecules in human cancers; however, whether lncRNAs are implicated the progression clear cell renal carcinoma (ccRCC) remains unclear.Candidate were selected using microarray analysis and quantitative real-time PCR (qRT-PCR) was performed to detect ccRCC tissues. Overexpression knocking down experiments vivo vitro uncover biological roles lncRNA-URRCC on proliferation invasion. Microarray, chromatin...
Hypoxia has been identified as a common contributor to tumor progression, including invasion and metastasis. However, the underlying mechanisms of enhanced metastasis under hypoxia remain unclear. A hypoxic microenvironment promotes renal cell carcinoma (RCC) by upregulating expression LOC100506178, which we named hypoxia-induced long non-coding RNA (lncRNA) associated with RCC (lncHILAR). Knockdown lncHILAR inhibited migration, whereas overexpression lncHILAR, conversely, facilitated...
We aimed to prospectively evaluate our previously proposed selective mediastinal lymph node (LN) dissection strategy for peripheral clinical T1N0 invasive NSCLC.This is a multicenter, prospective trial in China. set six criteria predicting negative LN stations and finally guiding dissection. Consolidation tumor ratio less than or equal 0.5, segment location, lepidic-predominant adenocarcinoma (LPA), hilar nodes (stations 10-12), visceral pleural invasion (VPI) were used separately...
Despite the fact that miRNAs play pivotal roles in various human malignancies, their molecular mechanisms influencing RCC are poorly understood.The expression of from and paired normal renal specimens was analysed by a combined computational experimental approach using two published datasets qRT-PCR assays. The functional role these further identified overexpression inhibition assays vivo vitro. Western blots, luciferase assays, chromatin immunoprecipitation were performed to investigate...
Abstract Purpose Although microRNAs (miRNAs) were revealed as crucial modulators in tumor metastasis and target therapy, our understanding of their roles metastatic renal cell carcinoma (mRCC) Sunitinib treatment was limited. Here we sought to identify human miRNAs that acted key regulators cancer treatment. Experimental design We focused on 2 published microarray data select out anchored miRNA then explored the miR-452-5p both vitro vivo, which downregulated after while upregulated (RCC)...
// Guang-hui Pan 1,* , Zheng Chen Lu Xu 1 Jing-hui Zhu Peng Xiang 2 Jun-jie Ma Yan-wen Li Xiao-yong Jia-li Fang Yu-he Guo Lei Zhang and Long-shan Liu 3 The Transplantation Centre, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China Center for Stem Cell Biology Tissue Engineering, SunYat-sen Guangdong, Laboratory of General Surgery, First Sun Yat-sen * These authors contributed to the work equally should be regarded as co-first Correspondence to: Pan, email: Keywords :...
Peanut (Arachis hypogaea. L) is an important oil crop worldwide. The common testa colours of peanut varieties are pink or red. But the with dark purple have been focused in recent years due to potential high levels anthocyanin, added nutritional value antioxidant. However, genetic mechanism regulating colour unknown. In this study, we found that was decided by female parent and controlled a single major gene named AhTc1. To identify candidate controlling testa, whole-genome...
Abstract Integrative analyses of transcriptomic and neuroimaging data have generated a wealth information about biological pathways underlying regional variability in imaging-derived brain phenotypes humans, but rarely nonhuman primates due to the lack comprehensive anatomically-defined atlas transcriptomics. Here we generate complementary bulk RNA-sequencing dataset 819 samples from 110 regions single-nucleus dataset, 162 cynomolgus macaques, examine link between brain-wide gene expression...
Aberrant expression of microRNA (miRNA) emerges as an important role in a wide range human malignances, and further identification well validation the change these endogenous non‐protein‐coding transcripts is warranted. Here, we identify novel epigenetic regulation miR‐766‐3p investigate its biological function clinical significance renal cell carcinoma (RCC). Bisulfate analysis elucidates that promoter highly methylated RCC tissues compared to non‐tumorous tissues. Notably, downregulation...
Abstract As a new plant biostimulant, poly-γ-glutamic acid (γ-PGA) may be an effective anti-drought agent that can efficiently alleviate the damage to plants under drought stress. In this study, effects of γ-PGA on physiological responses oilseed rape ( Brassica napus L.) seedlings stress were investigated using hydroponics. Growth and development significantly inhibited in polyethylene glycol-simulated environment. However, 12 d after application stress, fresh weight, chlorophyll content,...
Refractory/relapsed B cell lymphoma patients who received the available anti-CD19 chimeric antigen receptor (CAR) T cells may still experience a short duration of remission. Here in this study, we evaluated safety and efficacy novel dominant-negative programmed death-1 (PD-1) armored CAR cells. A total 9 (including 4 diffuse large lymphomas, DLBCL, 2 transformed follicular TFL, 3 FL) infusion at dose more than 1 × 106/kg. Grade ≥ cytokine release syndrome (CRS) neurotoxicity were observed...
The neurokinin-1 receptor (NK-1R) antagonists are approved as treatment for chemotherapy-associated nausea and vomiting in cancer patients. emerging role of the substance P-NK-1R system oncogenesis raises possibility repurposing well-tolerated NK-1R treatment. This study reports that human colorectal (CRC) patients with high expression have poor survival, SR140333 aprepitant induce apoptotic cell death CRC cells inhibit xenograft growth. cytotoxicity induced by is mediated induction...
Different gut microbiota is implicated in different diseases, including cancer. However, differences between individuals with clear cell renal carcinoma (ccRCC) and healthy are unclear. Here, we analyzed composition 51 ccRCC patients 40 controls using 16S rRNA sequencing analysis. We observed that Blautia, Streptococcus, [Ruminococcus]_torques_group, Romboutsia, [Eubacterium]_hallii_group were dominant positively associated ccRCC. isolated cultured Streptococcus lutetiensis to characterize...
Background and Aims: Portal vein tumor thrombosis (PVTT), an indicator of clinical metastasis, significantly shortens hepatocellular carcinoma (HCC) patients’ lifespan, no effective treatment has been established. We aimed to illustrate mechanisms underlying PVTT formation identified potential targets for intervention. Approach Results: Multi-omics data 159 HCC patients (including 37 cases with PVTT) was analyzed identify contributors metastasis. In vitro in vivo experiments were performed...
// Zhiguo Chen 1 , Rujian Zhu 2, 3 Jiayi Zheng 4 2 Chi Huang Junjie Ma Xu Wei Zhai 1, 5 and Junhua Department of Urology, Shanghai Tenth People’s Hospital, Tongji University School Medicine, Shanghai, China The Affiliated Nanjing Medical University, Pudong Fudan Center, Pathology, Renji Jiao Tong Correspondence to: Zhai, email: jacky_zw2002@hotmail.com Zheng, zhengjh0471@sina.com.cn Keywords: cryptotanshinone, renal cell carcinoma, proliferation, apoptosis, STAT3 Abbreviations: CPT:...
Background Prostate cancer (PCa) is a common malignancy occurring in men. As both an endocrine and gonadal organ, prostate closely correlated with androgen. So, androgen deprivation therapy (ADT) effective for treating PCa. However, patients will develop castration-resistant (CRPC) stage after ADT. Many other treatments CRPC exist, including chemotherapy. Vinblastine, chemotherapeutic drug, used to treat CRPC. resistance vinblastine. Genetic alterations have been speculated play critical...
CD44 is a critical cell-surface glycoprotein. However, its prognostic significance and correlation with tumor-infiltrating lymphocytes in clear cell renal carcinoma (ccRCC) are not well-understood.The mRNA protein levels of ccRCC were assessed. The value was analyzed the TCGA PrognoScan databases. functional enrichment immune infiltrates analyses conducted. STRING database used to analyze interactions CD44. Tissue array, western blot, qRT-PCR, transwell assay performed determine expression...