// Ran Tang 1, * , Chao Yang 2, Xiang Ma Younan Wang 1 Dakui Luo Chi Huang Zekuan Xu Ping Liu 3 Li Department of General Surgery, the First Affiliated Hospital Nanjing Medical University, Nanjing, China 2 Liver Transplantation Center and Key Laboratory on Living Donor Transplantation, Ministry Health, Oncology, These authors have contributed equally to this work Correspondence to: Yang, e-mail: pwkyangli@163.com Keywords: gastric cancer, microRNA-let-7a, PKM2 Received: June 08, 2015...

Carcinoma showing thymus-like differentiation (CASTLE) is a rare tumor occurring in the thyroid and soft tissues of neck. Treatments prognosis for CASTLE significantly differ from those associated with squamous cell carcinoma anaplastic carcinoma. To date, fewer than 100 cases have been reported. Given lack standardized treatment protocol diagnostic complexity, documenting these essential. A 74-year-old male patient was admitted to hospital due hoarseness lasting 1 month nodules over 2...

// Zhiguo Chen 1 , Rujian Zhu 2, 3 Jiayi Zheng 4 2 Chi Huang Junjie Ma Xu Wei Zhai 1, 5 and Junhua Department of Urology, Shanghai Tenth People’s Hospital, Tongji University School Medicine, Shanghai, China The Affiliated Nanjing Medical University, Pudong Fudan Center, Pathology, Renji Jiao Tong Correspondence to: Zhai, email: jacky_zw2002@hotmail.com Zheng, zhengjh0471@sina.com.cn Keywords: cryptotanshinone, renal cell carcinoma, proliferation, apoptosis, STAT3 Abbreviations: CPT:...

// Guanghui Hu 1 * , Binbin Dong 2, Jingwei Zhang 1, Wei Zhai 3 Tiancheng Xie Bisheng Huang Chi 4 Xudong Yao Junhua Zheng Jianping Che and Yun-Fei Xu Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China 2 Yancheng Third Yancheng, Jiangsu, Renji Jiaotong Nanjing Medical Nanjing, These authors have contributed equally to this work Correspondence to: Xu, email: xuyunfeibb@sina.com Che, chejianping77@126.com Zhai, jacky_zw2002@hotmail.com Keywords:...

Background and Aims: Numerous studies have identified BRAF V600E mutation as a predictive factor of anti-EGFR antibodies in colorectal cancer (CRC).However, the association between clinicopathological features remains unclear.Therefore, we aimed to conduct an updated comprehensive meta-analysis evaluate above issues.Methods: We performed systematic literature search from PubMed, Web Science, Embase, PMC database examining CRC patients.Odds ratio with 95% confidence interval were used...

Introduction This study aimed to investigate the effect of muscle-derived stem cell (MDSC) exosomes with overexpressed miR-214 on regeneration and repair rat sciatic nerve after crush injury its molecular mechanism. Methods First, primary MDSCs, Schwann cells (SCs) dorsal root ganglion (DRG) neurons were isolated cultured, characteristics MDSCs-derived identified by biology immunohistochemistry. NC mimics transfected obtain exo-NC exo-miR-214. An in vitro co-culture system was established...

Abstract While B cells in the tumor microenvironment (TME) might play important roles cancer progression, their impacts on renal cell carcinoma (RCC) metastasis remained unclear, which drew our attention to further explore. We found that RCC tissues could recruit more than surrounding normal from human clinical samples. Wound healing assay, transwell assay and 3D invasion assays demonstrated recruited cells, also known as tumor-educated (TEB), significantly increase migration invasion. In...

Distant metastasis of early gastric cancer is a rare subgroup and poorly understood. The present study aimed at summarizing the clinicopathological characteristics, prognosis, management clinical T1N0M1 (cT1N0M1) cancer. Between 2004 2015, patients diagnosed with cT1N0M1 were retrospectively analyzed using Surveillance, Epidemiology, End Results (SEER) database. A total 1093 identified. 49 (4.5%) received cancer-directed surgery, 113 (10.4%) managed radiotherapy. Compared other stage IV...

Tissue differentiation-inducing non-protein coding RNA (TINCR) is required for normal epidermal differentiation. TINCR also strongly overexpressed in human gastric cancer (GC) and contributes to carcinogenesis tumor progression. However, the association between polymorphisms risk of any diseases, such as GC, remains unknown. In present study, tag single nucleotide rs8113645, rs2288947, rs8105637, rs12610531 were analyzed 602 patients with GC age- sex-matched controls. Polymorphisms genotyped...

Context Zhishi Rhubarb Soup (ZRS) is a traditional Chinese medicine formula used in the clinic to treat acute cerebral infarction (ACI) for many years. However, exact mechanism of treatment remains unclear.Objective This study elucidates multitarget mechanisms underlying effects ZRS on ACI using network pharmacology analysis and verify its effect by performing animal experiments.Materials methods Using approach, multiple components, critical targets potential against were investigated. Six...

Purpose: Disheveled-binding antagonist of beta-catenin 1 ( DACT1 ) is involved in tumorigenesis through influencing cell apoptosis and proliferation. We aimed to investigate the effect three tag single-nucleotide polymorphisms (SNPs) (rs863091 C>T, rs17832998 rs167481 C>T) on occurrence gastric cancer (GC), their association with specific clinical characteristics, consideration functional relevance GC-related SNPs. Subjects methods: In this hospital-based case–control study, genotypes were...

Tripartite motif 59 (TRIM59) is a novel oncogenic driver in gastric cancer (GC) that implicated disease progression as well dismal survival. Genetic variants peculiar gene are likely candidates for conferring hereditary susceptibility. The role of TRIM59 polymorphism predicting the risk malignant diseases and its relevance to expression have not been discussed. Using HapMap tagSNPs approach, we screened three tag single nucleotide polymorphisms (SNPs) (rs1141023G>A, rs7629A>G, rs11706810T>C)...

Repeat surgery has usually been considered the first choice to solve paravalvular leaks of prosthetic valves, but it carries a high operative risk, mortality rate and an increased risk for re-leaks. Percutaneous closure such defects is possible, different approaches devices are used this purpose. For mitral leaks, constructing arterio-venous wire loop delivering device through antegrade approach most commonly technique. Transcatheter can also be performed transapical or retrograde...

BACKGROUND An escalating number of studies have provided identified evidence that sphingosine kinase 1 (SPHK1) plays an essential role in carcinogenesis. This present study was devised to seek the possible correlation two tag single-nucleotide polymorphisms (SNPs) SPHK1 (rs3744037 T>C, rs346801 C>T) with susceptibility gastric cancer (GC). METHODS case-control comprised 710 patients GC and gender- age-matched cancer-free individuals. The genotypes individuals were acquired by TaqMan-MGB...

Stroke has always been a major threat worldwide but is most severe in China, with 2.5 million new stroke cases each year and 7.5 survivors, placing heavy burden on the social national health care systems. Zhishi Rhubarb Soup (ZRS) traditional Chinese medicine (TCM) that used clinically for many years China. To explore potential mechanism of ZRS treatment stroke, liquid chromatography mass spectrometry (LC-MS) was performed.In this study, quantitative proteomic method LC-MS to analyse...

Survival benefit of adjuvant chemotherapy (ACT) remained controversial in patients with stage II/III rectal cancer (RC) who received neoadjuvant therapy and surgery. This study aimed to investigate the guiding role elevated pretreatment serum carcinoembryonic antigen (CEA) levels for receiving ACT yield pathological Tis-3N0 (ypTis-3N0) RC after radiotherapy Between 2004 2015, 10,973 ypTis-3N0 radical surgery were retrospectively analyzed using Surveillance, Epidemiology, End Results (SEER)...

Objective To study the effect of metformin on proliferation and apoptosis gastric cancer cells SGC7901 BGC823, possible mechanisms. Methods The cell was determined using counting kit-8 (CCK-8) assay. Cell cycle were analyzed by flow cytometry. The expression microRNA (miRNA, miR)-let-7a, Cyclin D1, cyclin-dependent kinase (Cdk)2, Cdk4 p21 detected real-time quantitative polymerase chain reaction (Real-time PCR) Western blotting. Results After treatment with different...

Abstract Background: Stroke has always been a big threat around the world, but most severe in China with 2.5 million new stroke cases each year and 7.5 survivors, which also laid heavy burden on social national healthcare system. The Zhishi Rhubarb Soup (ZRS) is Traditional Chinese Medicine (TCM) that used clinically for many years China. In order to explore potential mechanism of ZRS as pathogen stroke. this study, liquid chromatography mass spectrometry (LC-MS) was employed uncover...