A5027974825- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Parathyroid Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Fibroblast Growth Factor Research
Fudan University Shanghai Cancer Center
2018-2025
Shanghai Medical College of Fudan University
2018-2025
ShanghaiTech University
2024
Jiangsu Province Hospital
2015-2021
Nanjing Medical University
2015-2021
Nanjing University of Chinese Medicine
2020
// Chao Yang 1,* , Ran Tang Xiang Ma Younan Wang 1 Dakui Luo Zekuan Xu Yi Zhu 1,2 and Li Department of General Surgery, The First Affiliated Hospital Nanjing Medical University, Nanjing, China 2 Jiangsu Province Academy Clinical Medicine, Institute Tumor Biology, * These authors have contributed equally to this work Correspondence to: Yang, email: Keywords : gastric cancer, H19, polymorphism, genotype Received November 17, 2014 Accepted March 19, 2015 Published April 15, Abstract Long...
// Ran Tang 1, * , Chao Yang 2, Xiang Ma Younan Wang 1 Dakui Luo Chi Huang Zekuan Xu Ping Liu 3 Li Department of General Surgery, the First Affiliated Hospital Nanjing Medical University, Nanjing, China 2 Liver Transplantation Center and Key Laboratory on Living Donor Transplantation, Ministry Health, Oncology, These authors have contributed equally to this work Correspondence to: Yang, e-mail: pwkyangli@163.com Keywords: gastric cancer, microRNA-let-7a, PKM2 Received: June 08, 2015...
Abstract Long noncoding RNAs (lncRNAs) are emerging as important regulators of tumorigenesis and frequently dysregulated in cancers. Here, we identify a critical lncRNA TRPM2-AS which is aberrantly expressed gastric cancer (GC) tissues by screening The Cancer Genome Atlas Program(TCGA) database GC cohort, its upregulation clinically associated with advanced pathologic stages poor prognosis patients. Silencing inhibits the proliferation, metastasis radioresistance cell whereas ectopic...
Abstract Background Circular RNAs (circRNAs) generated by back‐splicing of precursor mRNAs (pre‐mRNAs) are often aberrantly expressed in cancer cells. Accumulating evidence has revealed that circRNAs play a critical role the progression several cancers, including colorectal (CRC). However, current understandings emerging functions CRC lipid metabolism and underlying molecular mechanisms still limited. Here, we aimed to explore circCAPRIN1 regulating tumorigenesis. Methods circRNA microarray...
Background The prognostic value of tumor regression grade (TRG) after neoadjuvant chemoradiotherapy for rectal cancer is inconsistent in the literature. Both TRG and post-therapy lymph node (ypN) status could reflect efficacy therapy. Here, we explored whether combined with ypN be a factor MRI-based node-positive (cN+) following chemoradiotherapy.
Background/Aims: Gastric cancer (GC) is one of the most prevalent digestive malignancies. MicroRNAs (miRNAs) are involved in multiple cellular processes, including oncogenesis, and miR-592 itself participates many malignancies; however, its role GC remains unknown. In this study, we investigated expression molecular mechanisms GC. Methods: Quantitative real-time PCR immunohistochemistry were performed to determine putative targets human tissues cell lines. Proliferation, migration, invasion...
Abstract Background Accumulating evidence demonstrated immune/inflammation‐related implications of basophils in affecting tissue microenvironment that surrounded a tumor, and this study aimed to elucidate the clinical value serum basophil count level. Methods Between December 2007 September 2013, 1029 patients diagnosed with stage I–III CRC Fudan University Shanghai Cancer Center meeting essential criteria were identified. The Kaplan–Meier method was used construct survival curves. Several...
Resistance to oxaliplatin is a major obstacle for the management of locally advanced and metastatic colon cancer (CC). Although long noncoding RNAs (lncRNAs) play key roles in CC, relationships between lncRNAs resistance have been poorly understood yet.Chemo-sensitive chemo-resistant organoids were established from tissues oxaliplatin-sensitive or -resistant patients. Analysis patient cohort indicated that lnc-RP11-536 K7.3 had potential oncogenic role CC. Further, series functional vitro...
This study aimed to investigate circumferential resection margin (CRM) as a prognostic factor for long-term oncologic survival after rectal cancer surgery.Patients diagnosed with malignant between 1 January 2010 and 31 December 2014, from the Surveillance, Epidemiology, End Results (SEER) program were identified this study. The patients divided into five CRM groups compare baseline characteristics assess cancer-specific (CSS): 0-1 mm, 1.1-2.0 2.1-5.0 5.1-10.0 >10 mm. main endpoint was...
UTX (encoded by KDM6A), a histone demethylase for H3K27me2/3, is frequently mutated in human cancers. However, its functional and regulatory mechanisms colorectal cancer (CRC) remain unclear.Immunohistochemistry staining was used to investigate the clinical relevance of CRC. Additionally, we generated spontaneous mouse CRC model with conditional Utx knockout explore role tumorigenesis. Post-translational regulation determined co-immunoprecipitation immunoblot analyses.Herein, identify that...
Abstract Background While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood. Methods We conducted cell proliferation assays on CRC cells with or without depletion squalene epoxidase (SQLE), 5-fluorouracil (5-FU) treatment. Additionally, xenograft mouse model was utilized to explore impact SQLE chemosensitivity 5-FU. RNA-sequencing analysis and immunoblotting were performed...
Background: In non-metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC), traditional prognostic factors, such as pN staging, often fail to distinguish patient outcomes effectively. Methods: This retrospective study included a cohort of 792 dMMR CRC patients who underwent surgical treatment without neoadjuvant chemoradiotherapy or immunotherapy. Traditional factors were compared with lymph node-based models (NLN, LNR, LOODS) for their ability predict overall survival (OS) and...
Background: The optimal interval from completion of neoadjuvant chemoradiotherapy (CRT) to surgery in locally advanced rectal cancer (LARC) remains controversial. It seems that delayed is associated with an increase pathological complete response rates. However, the prognostic effect poor responders unclear. Materials and Methods: Patients mid- or distal undergoing CRT followed by total mesorectal excision at a university teaching center between June 2010 December 2018 were retrospectively...
Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified a tumor gene in variety of cancers, including colorectal cancer. Recent years have witnessed the importance metabolism transformation cancer cell malignancies maintenance. Aberrant is considered to be hallmark Our previous studies demonstrated that KL played negative roles colon proliferation metastasis. However, its role reprogramming seldom reported. The aim this study examine aerobic glycolysis...
Long noncoding RNA (lncRNA) phosphatase and tensin homolog pseudogene 1 (PTENP1) is significantly downregulated in gastric cancer (GC), playing critical roles GC progression. However, the association between PTENP1 genetic variants risk has not yet been reported. Using TaqMan technology, three lncRNA tag single nucleotide polymorphisms (tagSNPs) (rs7853346 C>G, rs865005 C>T, rs10971638 G>A) were genotyped 768 patients cancer-free controls a Chinese population. We found that subjects...
P-TNM staging system for colon cancer: combination of P-stage and AJCC TNM improving prognostic prediction clinical management Qi Liu,1,2 Dakui Luo,1,2 Sanjun Cai,1,2 Qingguo Li,1,2 Xinxiang Li1,2 1Department Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic China; 2Department Oncology, Medical College, University, China Aim: This study focused on the American Joint Committee demonstrated an improvement in accuracy cancer using P–TNM system. Patients...
Purpose: Gastric adenosquamous carcinoma (ASC) is a rare pathological type with poorly understood clinicopathological features.The purpose of this study to identify the characteristics gastric ASC patients.Methods: Using Surveillance, Epidemiology, and End Results (SEER) database (2000 2014), patients (N=93) or adenocarcinoma (AC) (N=41794) stomach were included.The epidemiology, tumor features, treatment, outcomes between these two groups compared. Results:The incidences from 1983 2014...
So far, many existing evidences indicate that microRNAs (miRNA) are closely associated with the tumorigenesis and progression of various tumors. It has been reported miR-1301-3p is abnormally expressed in several malignant However, role gastric cancer (GC) remains unclear worth studying. Through qRT-PCR, expression SIRT1 were detected GC tissues cells. The cell proliferation cycle measured through CCK-8 assay clone formation assay. Dual luciferase reporter was used to determine target...
The present study analyzed the nonbiological factors (NBFs) together with American Joint Committee on Cancer (AJCC) Tumor-Node-Metastasis (TNM) staging system to generate a refined, risk-adapted stage for clinical treatment of colon cancer.
Tissue differentiation-inducing non-protein coding RNA (TINCR) is required for normal epidermal differentiation. TINCR also strongly overexpressed in human gastric cancer (GC) and contributes to carcinogenesis tumor progression. However, the association between polymorphisms risk of any diseases, such as GC, remains unknown. In present study, tag single nucleotide rs8113645, rs2288947, rs8105637, rs12610531 were analyzed 602 patients with GC age- sex-matched controls. Polymorphisms genotyped...
Background:The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial.Recently, however, several studies have reported the definite survival benefit (ACT) in T4 disease (stage IIB and IIC) among patients.The following study investigates efficacy ACT patients with poorly differentiated IIA cancer.Methods: The first cohort eligible (N=38384) diagnosed was selected from Surveillance, Epidemiology, End Results database (SEER) between January 1, 2004, December...