Yonghui Chen

ORCID: 0000-0003-4006-9275
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About
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Research Areas
  • Renal cell carcinoma treatment
  • Renal and related cancers
  • Bladder and Urothelial Cancer Treatments
  • Aortic aneurysm repair treatments
  • Renal and Vascular Pathologies
  • Cancer Genomics and Diagnostics
  • Aortic Disease and Treatment Approaches
  • Multiple and Secondary Primary Cancers
  • MRI in cancer diagnosis
  • Infectious Aortic and Vascular Conditions
  • Ferroptosis and cancer prognosis
  • Urinary and Genital Oncology Studies
  • Vascular Procedures and Complications
  • Cardiac, Anesthesia and Surgical Outcomes
  • Pediatric Urology and Nephrology Studies
  • Epigenetics and DNA Methylation
  • Venous Thromboembolism Diagnosis and Management
  • Pancreatic and Hepatic Oncology Research
  • Cancer Immunotherapy and Biomarkers
  • Urologic and reproductive health conditions
  • Anatomy and Medical Technology
  • Radiomics and Machine Learning in Medical Imaging
  • Anesthesia and Pain Management
  • Sarcoma Diagnosis and Treatment
  • Kidney Stones and Urolithiasis Treatments

Beijing Sport University
2023-2025

Shanghai Jiao Tong University
2015-2024

Renji Hospital
2015-2024

Tianjin Medical University General Hospital
2021-2024

First Affiliated Hospital of Zhengzhou University
2024

Third Affiliated Hospital of Southern Medical University
2024

Yichun University
2024

SingHealth
2023

Henan Provincial People's Hospital
2022

Zhengzhou University
2022

Abstract Purpose Although microRNAs (miRNAs) were revealed as crucial modulators in tumor metastasis and target therapy, our understanding of their roles metastatic renal cell carcinoma (mRCC) Sunitinib treatment was limited. Here we sought to identify human miRNAs that acted key regulators cancer treatment. Experimental design We focused on 2 published microarray data select out anchored miRNA then explored the miR-452-5p both vitro vivo, which downregulated after while upregulated (RCC)...

10.1186/s12943-018-0906-x article EN cc-by Molecular Cancer 2018-11-12

The purpose of this study was to assess the relation between tumor enhancement on multiphase contrast-enhanced CT images and Fuhrman grade clear cell renal carcinoma.A single-institution retrospective review conducted records 255 patients who underwent radical or partial nephrectomy received a histologic diagnosis carcinoma. Two radiologists recorded radiographic features each patient, including attenuation value lesion, lesion size, calcification within cystic versus solid appearance,...

10.2214/ajr.13.12297 article EN American Journal of Roentgenology 2014-08-22

Purpose: The aim of this study was to evaluate the midterm efficacy and safety a single-branch Castor stent graft in treatment thoracic aortic disease. Materials Methods: Clinical data 106 patients with disease treated at 3 centers were collected between May 2018 June 2023. indicators included technical success, stent-related complication, reintervention, retrograde dissection, endoleak, distal graft–induced entry (dSINE), branch patency, mortality. outcomes for multibranch reconstruction...

10.1177/15266028241234500 article EN Journal of Endovascular Therapy 2024-02-27

We evaluated the functional outcome, safety and efficacy of zero ischemia laparoscopic radio frequency ablation assisted tumor enucleation compared with conventional partial nephrectomy.A prospective randomized controlled trial was conducted from April 2013 to March 2015 in patients cT1a renal scheduled for nephron sparing surgery. All were followed at least 12 months. Patients group underwent after without hilar clamping. The primary outcome change glomerular filtration rate affected kidney...

10.1016/j.juro.2015.12.115 article EN The Journal of Urology 2016-02-22

A combination of axitinib and immune checkpoint inhibitors (ICIs) demonstrated promising efficacy in the treatment advanced renal cell carcinoma (RCC). This study aims to prospectively evaluate safety, efficacy, biomarkers neoadjuvant toripalimab plus non-metastatic clear RCC. is a single-institution, single-arm phase II clinical trial. Patients with biopsy-proven RCC (T2-T3N0-1M0) are enrolled. will receive 5 mg twice daily combined 240 every 3 weeks (three cycles) for up 12 weeks. then...

10.1136/jitc-2023-008475 article EN cc-by-nc Journal for ImmunoTherapy of Cancer 2024-06-01

Abstract While B cells in the tumor microenvironment (TME) might play important roles cancer progression, their impacts on renal cell carcinoma (RCC) metastasis remained unclear, which drew our attention to further explore. We found that RCC tissues could recruit more than surrounding normal from human clinical samples. Wound healing assay, transwell assay and 3D invasion assays demonstrated recruited cells, also known as tumor-educated (TEB), significantly increase migration invasion. In...

10.1038/s41419-020-2355-x article EN cc-by Cell Death and Disease 2020-03-02

Abstract This study aimed to develop and validate a novel nomogram risk assessment model predict the possibility of type II endoleak (T2EL)-related re-intervention. The data 455 patients with abdominal aortic aneurysms who underwent elective endovascular aneurysm repair (EVAR) procedures between January 2018 December 2021 at our single center were retrospectively reviewed. Following implementation exclusion criteria, 283 finally included divided into T2EL-related re-intervention (n = 42)...

10.1038/s41598-022-27356-8 article EN cc-by Scientific Reports 2023-01-02

The aim of this study was to investigate the minimally invasive cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) approach in management renal cell carcinoma (RCC) with level III or IV inferior vena cava (IVC) thrombus evaluate survival outcomes. We performed a retrospective analysis on 32 RCC patients IVC that underwent nephrectomy thrombectomy via CPB/DHCA between January 2007 December 2013. Perioperative variables (for example, operative time, CPB duration,...

10.1186/s12957-015-0584-8 article EN cc-by World Journal of Surgical Oncology 2015-04-21

Objective: To conduct a meta-analysis to assess the safety and efficacy of t-Branch off-the-shelf multibranched endograft for treatment thoracoabdominal aortic aneurysm (TAAA). Data Sources: PubMed, Embase, Web Science. Review Methods: Online databases were searched from June 2012 March 2023. The data pooled together using random-effects model proportions. outcomes overall included technical success, spinal cord ischemia, target vessel occlusion, type I or III endoleak, reintervention, early...

10.1177/15266028231220322 article EN Journal of Endovascular Therapy 2023-12-29

This study aimed to separately compare and rank the effect of various living-low training-high (LLTH) modes on aerobic anaerobic performances in athletes, focusing training intensity, modality, volume, through network meta-analysis. We systematically searched PubMed, Web Science, Embase, EBSCO, Cochrane from their inception date June 30, 2023. Based hypoxic modality intensity duration work intervals, LLTH was divided into intermittent exposure, continuous training, repeated sprint hypoxia...

10.1371/journal.pone.0297007 article EN cc-by PLoS ONE 2024-04-18

Radiofrequency ablation (RFA) has been considered as an important therapy for small renal lesions. The main limitation of RFA, however, is the lack pathologic confirmation complete tumor eradication. A single center, open label, randomized pilot study was designed to evaluate whether contrast-enhanced ultrasonography (CEUS) with Sonovue, performed in real time could allow us determine end point during laparoscopic radiofrequency (LRFA) and clinical outcome this method.Ninety-six patients...

10.1089/end.2012.0694 article EN Journal of Endourology 2013-02-27

Renal cell carcinoma (RCC) is one of the most malignant tumors worldwide. Among all subtypes RCC, clear-cell RCC (ccRCC) common and aggressive one. The difficulty in overcoming resistance traditional treatment a threat for ccRCC therapies. Therefore, to understand mechanism that underlies progression critical new drug development. In present study, we identified miR-184 could be downregulated by c-Myc, which different from standard opinion c-Myc target miR-184. Overexpression pre-miR-184...

10.3892/ijo.2016.3622 article EN International Journal of Oncology 2016-07-14

Objective To evaluate the mid-term outcomes of different treatment strategies for internal iliac artery (IIA) during EVAR. Methods This was a retrospective study. All patients undergoing EVAR, who required at least one side IIA from January 2013 to July 2022 in single center, were included. According IIA, divided into UP (unilateral preservation), BP (bilateral preservation) and BE embolization) groups. The primary included buttock claudication, bowel ischemia iliac-related reintervention....

10.1177/00368504241274998 article EN cc-by-nc Science Progress 2024-07-01

Triple‑negative breast cancer (TNBC) is a subtype of that negative for oestrogen receptor, progesterone receptor and human epidermal growth factor 2 expression. Locally advanced metastatic TNBC not only have worse prognosis are more invasive than TNBC, but also the most immunogenic subtypes cancer. There still lack clarity regarding optimal treatment locally or TNBC. The present study aimed to assess efficacy safety programmed cell death protein 1 (PD‑1)/programmed ligand (PD‑L1)...

10.3892/ol.2024.14803 article EN Oncology Letters 2024-11-13

Objective: Preoperative aspects and dimensions used for an anatomical classification is a standardized system to assess the complexity of renal tumors its impact on perioperative outcomes partial nephrectomy. The objective apply preoperative in series Chinese patients undergoing open or laparoscopic Methods: A total 195 consecutive treated with nephrectomy between June 2008 May 2011 were included this analysis. All images clinical records retrospectively evaluated. Complication rate, warm...

10.1111/j.1442-2042.2012.02973.x article EN International Journal of Urology 2012-03-29
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