A5108049989- Biochemical Analysis and Sensing Techniques
- Reproductive System and Pregnancy
- Advanced Chemical Sensor Technologies
- Cardiac Valve Diseases and Treatments
- Endometriosis Research and Treatment
- Olfactory and Sensory Function Studies
- Reproductive Biology and Fertility
- Blood Pressure and Hypertension Studies
- Renin-Angiotensin System Studies
- Ovarian function and disorders
- Cardiovascular Function and Risk Factors
- Immune cells in cancer
- Gynecological conditions and treatments
- Selenium in Biological Systems
- Cardiac, Anesthesia and Surgical Outcomes
- Fibroblast Growth Factor Research
- Cardiovascular Health and Disease Prevention
- Ectopic Pregnancy Diagnosis and Management
- School Health and Nursing Education
- Sarcoma Diagnosis and Treatment
- Healthcare cost, quality, practices
- Pregnancy and Medication Impact
- Vascular anomalies and interventions
- Cerebrovascular and Carotid Artery Diseases
- Greenhouse Technology and Climate Control
Shanghai Jiao Tong University
2014-2025
Shanghai First People's Hospital
2022-2025
Chinese PLA General Hospital
2011-2025
National Medical Products Administration
2025
Guangzhou University of Chinese Medicine
2024
Renji Hospital
2017-2024
International Peace Maternity & Child Health Hospital
2022-2024
Dalian Institute of Chemical Physics
2023
Chinese Academy of Sciences
2023
Harvard University
2022
Umami taste receptor type 1 member 1/3 (T1R1/T1R3) heterodimer has multiple ligand-binding sites, most of which are located in T1R1-Venus flytrap domain (T1R1-VFT). However, the critical binding process T1R1-VFT/umami ligands remains largely unknown. Herein, T1R1-VFT was prepared with a sufficient amount and functional activity, its characteristics typical umami molecules (monosodium l-glutamate, disodium succinate, beefy meaty peptide, inosine-5′-monophosphate) were explored via...
Umami peptides are small molecular weight oligopeptides that play a role in umami taste attributes. However, the identification of is easily limited by environmental conditions, and abundant source high chromatographic separation efficiency remain difficult. Herein, we report robust strategy based on phage random linear heptapeptide library targets T1R1-Venus flytrap domain (T1R1-VFT). Two candidate (MTLERPW MNLHLSF) were readily identified with affinity for T1R1-VFT binding (KD MW-7 MF-7...
Polycystic ovary syndrome (PCOS) is a major cause of infertility in women reproductive age. However, its exact etiology remains unknown. In this study, we sequenced microRNAs (miRNAs) human follicular fluid and identified 16 downregulated 3 upregulated miRNAs PCOS group compared with non-PCOS group. Among the differential expressed miRNAs, miR-335-5p was verified lower abundance than using quantitative real-time polymerase chain reaction. Besides, negatively correlated antral follicle count,...
Purpose: We designed a semi-supervised method that effectively utilized few-slice-annotated data for efficient MRI segmentation.
Abstract The objectives of the present study were to investigate effects selenium (Se) supplementation during in vitro maturation (IVM) on developmental capacity yak ( Bos grunniens ) oocytes. Nuclear maturation, DNA integrity, glutathione peroxidase (GSH‐Px) activity, subsequent embryonic development, and gene expression after fertilization (IVF) evaluated. Se concentrations plasma follicular fluid 0.142 0.069 μg/mL, respectively. damage cumulus cells decreased significantly with 2 4 μg/mL...
Abstract STUDY QUESTION Could the risk of subsequent pregnancy loss be predicted based on factors recurrent (RPL) patients? SUMMARY ANSWER A nomogram, constructed from independent identified through multivariate logistic regression, serves as a reliable tool for predicting likelihood in RPL patients. WHAT IS KNOWN ALREADY Approximately 1–3% fertile couples experience RPL, with over half lacking clear etiological factor. Assessing rate patients and identifying high-risk groups early...
Abstract Insufficient endometrial angiogenesis during peri‐implantation impairs receptivity (ER), which contributes to recurrent implantation failure (RIF) in vitro fertilization and embryo transfer (IVF‐ET). Angiopoietin‐like protein 4 (ANGPTL4) acts as a multifunctional secretory is involved the regulation of lipid metabolism various tissues including endometrium. Herein, we found decreased ANGPTL4 expression tissue serum period 18 RIF‐affected women with elevated uterine arterial...
Introduction Lung metastasis occurs in parts of the bladder carcinoma (BC) patients but represents highest severity and a poor outcome disease. The molecular mechanism underlying lung BC is not fully understood. Fibroblast growth factor receptor 2 (FGFR2) signaling plays substantial role cell invasion. In this study, we assessed regulation alternative splicing FGFR2 by epithelial regulatory proteins (ESRPs) BC. Methods Gene profile comparison with adjacent non-tumor tissue was obtained from...
Decidual polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are essential to immune tolerance during pregnancy. A reduction in the number of these is associated with unexplained recurrent pregnancy loss (URPL). In our previous study, we reported that PMN-MDSCs a group mature neutrophils activated by decidua microenvironment. present show microenvironment induces substantial lipid accumulation their differentiation PMN-MDSCs. Lower levels detected from URPL patients, and amount...
Abstract Background Carotid ultrasound is a noninvasive tool for risk assessment of coronary artery disease ( CAD ). There no consensus on which carotid parameter constitutes the best measurement atherosclerosis. We investigated model parameters and clinical factors CRF ) has highest predictive value . Materials methods enrolled 2431 consecutive patients who have suspected underwent angiography with measurements intima‐media thickness CIMT ), total number plaques areas different types...
To analyze the effects of high ovarian response on endometrial collagen synthesis and related gene expression during peri-implantation period in patients undergoing vitro fertilization-embryo transfer.Peripheral blood biopsies were obtained from infertile women day 6 after oocytes retrieval or ovulation 16 stimulated cycles (SC) natural (NC) respectively. Serum estrogen (E2 ), progesterone (P4 histological staging, collagen, matrix metalloproteinases (MMP2, 9) tissue inhibitors (TIMP1, 3)...
This report aims to evaluate the effect of atorvastatin (Ator) on left ventricular systolic function in myocardial infarction (MI) rats. Forty healthy adult Sprague-Dawley rats were randomly divided into four groups: Ator group, MI sham-operation group and normal group. The anterior descending coronary arteries ligated establish model; after modeling, was treated with for 4 consecutive weeks. echocardiographic detection performed; peak velocities, strain rates analyzed using 2D-STI...
Rationale: Lipoma arborescens (LA) is a rare, benign proliferative disorder of the synovial lining that typically affects middle-aged individuals, predominantly in knee joint. However, its occurrence younger patients unusual and may pose unique diagnostic therapeutic challenges. This case report aims to highlight clinical, imaging, aspects LA young adult, thereby expanding understanding presentation this age group. Patient concerns: A 22-year-old male presented with acute swelling pain right...