A5100764051- Renal cell carcinoma treatment
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Renal and Vascular Pathologies
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Multiple and Secondary Primary Cancers
- MRI in cancer diagnosis
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Water Systems and Optimization
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- Anatomy and Medical Technology
- Cancer Mechanisms and Therapy
- Urologic and reproductive health conditions
- Ureteral procedures and complications
- Ubiquitin and proteasome pathways
- Acupuncture Treatment Research Studies
- Colorectal Cancer Surgical Treatments
- Dermatology and Skin Diseases
Jiangnan University
2024
Shanghai Jiao Tong University
2013-2023
Renji Hospital
2011-2023
Tianjin Medical University Cancer Institute and Hospital
2022-2023
Wanhua Chemical (China)
2022
Beijing Obstetrics and Gynecology Hospital
2020
Peking University
2010-2020
Peking University Third Hospital
2010-2020
Ministry of Education of the People's Republic of China
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
It is increasingly clear that microRNAs (miRNAs) play an important role in many diseases, including tumorigenesis. However, the mechanisms by which miRNAs regulate bladder cancer development remain poorly understood. Here, we evaluated expression of microRNA‐203 (miR‐203) tissues using real‐time PCR, and defined target genes biologically functional effect luciferase reporter assay, flow cytometry western blot analysis. We first verified miR‐203 was decreased tissues. Moreover, ectopic...
Abstract Background and Objective High‐mobility group box 1 (HMGB1) is a versatile protein with intranuclear extracellular functions that involved in numerous biological pathological processes, such as transcription, DNA repair, response to infection inflammation. HMGB1 overexpression has been reported variety of human cancers. However, the clinical significance expression bladder cancer (BC) remains unclear. This study aimed investigate correlations between prognosis patients BC. Methods...
Micro RNA s (mi s), which negatively regulate protein expression by binding protein‐coding mRNA s, have been integrated into cancer development and progression as either oncogenes or tumor suppressor genes. mi R ‐30c was reported to be downregulated in several types of cancer. However, its role human renal cell carcinoma ( RCC ) remains largely unknown. Here, we show that is significantly tissues lines. We found miR‐30c downregulation could induced hypoxia cells a hypoxia‐inducible factors...
MicroRNAs (miRNAs) are a class of small non-coding RNAs that bind protein-coding mRNAs and negatively regulate protein expression by translation repression or mRNA cleavage. Accumulating evidence suggests miRNAs involved in cancer development progression, acting as either tumor suppressors oncogenes. It has been shown miR-199a-3p was significantly down-regulated several types cancers. However, its role relevance renal cell carcinoma (RCC) still largely unknown. Here, we show is human RCC...
Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by overexpression of monocyte chemoattractant protein-1 (MCP-1) in bladder tissues and induction mast cell (MC) degranulation. This study was undertaken to explore the mechanism action MCP-1 development IC/BPS.A rat model IC/BPS developed perfusing bladders nine SPF- grade female Sprague-Dawley rats with protamine sulfate lipopolysaccharide (PS+LPS). histamine levels tissue urine were detected immunohistochemistry ELISA....
We evaluated the functional outcome, safety and efficacy of zero ischemia laparoscopic radio frequency ablation assisted tumor enucleation compared with conventional partial nephrectomy.A prospective randomized controlled trial was conducted from April 2013 to March 2015 in patients cT1a renal scheduled for nephron sparing surgery. All were followed at least 12 months. Patients group underwent after without hilar clamping. The primary outcome change glomerular filtration rate affected kidney...
Dormant cancer cells account for recurrence, distant metastasis and drug resistance which lead to poor prognosis in colorectal (CRC). However, little is known about the molecular mechanisms regulating tumor cell dormancy how eliminate dormant cells. Recent studies indicate autophagy affects survival. Here, we found that polo-like kinases 4 (PLK4), a central regulator of cycle proliferation, plays crucial role CRC both vitro vivo. Downregulation PLK4 induced inhibited migration invasion...
Abstract Objective —To investigate physiologic effects of electroacupuncture (EA) combined with xylazine administration in goats. Animals —48 healthy crossbred Procedures —Goats were randomly allotted to 8 groups 3 (nonpregnant and nonlactating) female goats male each. The treatment as follows: 1 EA group, (0.1, 0.2, 0.4 mg/kg, IM) groups, plus control group. Electroacupuncture was performed for 90 minutes. Xylazine administered 20 minutes after performed. Pain threshold, heart rate, mean...
The aim of this study was to investigate the minimally invasive cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) approach in management renal cell carcinoma (RCC) with level III or IV inferior vena cava (IVC) thrombus evaluate survival outcomes. We performed a retrospective analysis on 32 RCC patients IVC that underwent nephrectomy thrombectomy via CPB/DHCA between January 2007 December 2013. Perioperative variables (for example, operative time, CPB duration,...
Levofloxacin is a synthetic fluoroquinolone that usually used to treat chronic bacterial prostatitis.We investigated the safety and efficacy of levofloxacin compared with ciprofloxacin for treatment prostatitis in Chinese patients.This was multicenter, open-label, randomized controlled non-inferiority trial.Four hundred seventy-one patients clinical symptoms/ signs were enrolled into study, 408 microbiologically confirmed prostatitis, who either oral (500 mg q.d.) or b.i.d.) 4...
Castration-resistant prostate cancer (CRPC) is an advanced form of cancer. Despite some progresses have been made, the mechanism CRPC development still largely unknown, including genes involved in its not well defined. Here, we identifiedPRKAR2B to be a gene over-expressingin castration-resistant by analyzing different online databases. Followed functional validation experiments showed that PRKAR2B promoted cell proliferation and invasion, inhibited apoptosis. Whole genome transcriptome GO...
Correspondence to: Yonghui Chen; Wei Xue. Department of Urology, Renji Hospital, School Medicine, Shanghai Jiaotong University, 200127, China. Email: cyh1488@163.com; xuewei@renji.com.Aberrantly expressed microRNAs play important biological functions in the pathogenesis, progression and metastasis numerous malignancies. Thus, further identification these non-coding transcriptions is warranted.miRNAs expression data renal cell carcinoma (RCC) as well normal tissue samples was downloaded from...
The study explores whether miR-139-5p targeting LPAR4 affects epithelial-mesenchymal transition (EMT) and fibrosis in post-menopausal women with interstitial cystitis (IC) via the PI3K/Akt signaling pathway. Bladder tissues of IC normal bladder were collected. pathology was observed by HE, Masson Picrosirius red staining. positive expression rate determined IHC. ELISA performed to detect levels IL-6, IL-8, IL-10, TNF-α. Rat models randomized into seven different groups. miR-139-5p, LPAR1,...
Radiofrequency ablation (RFA) has been considered as an important therapy for small renal lesions. The main limitation of RFA, however, is the lack pathologic confirmation complete tumor eradication. A single center, open label, randomized pilot study was designed to evaluate whether contrast-enhanced ultrasonography (CEUS) with Sonovue, performed in real time could allow us determine end point during laparoscopic radiofrequency (LRFA) and clinical outcome this method.Ninety-six patients...
In order to investigate the dynamic processes of mRNA levels proenkephalin, proopiomelanocortin, prodynorphin, and opioid receptors (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>δ</mml:mi></mml:mrow></mml:math>-,<mml:math id="M2"><mml:mrow><mml:mi>μ</mml:mi></mml:mrow></mml:math>-, and<mml:math id="M3"><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>-receptor) induced by electroacupuncture (EA) in central nerve system, goats were stimulated EA 60 Hz...
Renal cell carcinoma (RCC) is one of the most malignant tumors worldwide. Among all subtypes RCC, clear-cell RCC (ccRCC) common and aggressive one. The difficulty in overcoming resistance traditional treatment a threat for ccRCC therapies. Therefore, to understand mechanism that underlies progression critical new drug development. In present study, we identified miR-184 could be downregulated by c-Myc, which different from standard opinion c-Myc target miR-184. Overexpression pre-miR-184...
To explore the effect of cytosolic phospholipase A2α (cPLA2α) on hepatocellular carcinoma (HCC) cell adhesion and underlying mechanisms.Cell adhesion, detachment, hanging-drop assays were utilized to examine cPLA2α cell-matrix cell-cell adhesion. Downstream substrates effectors screened via a phospho-antibody microarray. Associated signaling pathways identified by functional annotation tool DAVID. Candidate proteins verified using Western blot colocalization was investigated...