A5101951575- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Renal and related cancers
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Higher Education and Teaching Methods
- MicroRNA in disease regulation
- Empathy and Medical Education
- Healthcare and Venom Research
- Childhood Cancer Survivors' Quality of Life
- Innovative Teaching Methodologies in Social Sciences
- Cancer Genomics and Diagnostics
- Spine and Intervertebral Disc Pathology
- Vitamin D Research Studies
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Acupuncture Treatment Research Studies
- Pancreatic and Hepatic Oncology Research
- Education and Work Dynamics
- Education and Learning Interventions
Renji Hospital
2011-2024
Shanghai Jiao Tong University
2011-2024
Beijing University of Chinese Medicine
2024
A combination of axitinib and immune checkpoint inhibitors (ICIs) demonstrated promising efficacy in the treatment advanced renal cell carcinoma (RCC). This study aims to prospectively evaluate safety, efficacy, biomarkers neoadjuvant toripalimab plus non-metastatic clear RCC. is a single-institution, single-arm phase II clinical trial. Patients with biopsy-proven RCC (T2-T3N0-1M0) are enrolled. will receive 5 mg twice daily combined 240 every 3 weeks (three cycles) for up 12 weeks. then...
Background: Warm acupuncture (WA) has analgesic and anti-inflammatory effects.However, the underlying mechanism of these effects remain unclear.Objectives: To explore WA potential in male Sprague-Dawley rats with non-compressive lumbar disk herniation (LDH) caused by autologous nucleus pulposus (NP) transplantation.Methods: We used low-frequency (2 Hz) electrical stimulation (40℃) to treat GB30 BL54 acupoints for 30 mins per day.We monitored paw withdrawal threshold during experiment...
Abstract Background Cell division cycle associated 5 (CDCA5) plays ontogenetic role in various human cancers. However, its specific function and regulatory mechanism ccRCC remain uncertain. Methods Immunohistochemistry western blots were performed to investigate the expression of CDCA5 tissues. Genetic knockdown upregulation functional roles proliferation, migration, apoptosis sunitinib resistance. Furthermore, Co-IP assay LC–MS/MS underlying mechanisms. Results We found that is frequently...
112 Background: Cystectomy (RC) with or without (neo)adjuvant cisplatin-based chemotherapy [(N)AC] is standard in fit patients (pts) MIBC. For those who decline are ineligible for RC, trimodality bladder preservation therapy (TMT) recommended. However, about 40% of MIBC pts cisplatin-ineligible refuse chemotherapy. A new bladder-preserving urgently needed. DV an antibody-drug conjugate directed to HER2, which highly expressed urothelial cancer(UC). In a combined analysis two phase II...
Objective: To study the expression of IRX1 (Iroquois homeobox gene) in cervical cancer and its correlation with clinical stage cancer. Methods: A total 61 patients from January 2015 to 2017 were enrolled this study, which 15 classified as phase Ⅰ cancer, 22 Ⅱ, 19 cases Ⅲ, 5 Ⅳ followed FIGO staging criteria.The protein Hela, C4-1 Siha cell lines detected by Western blot compared normal human epithelial cells HCerEpiC.Collected cancerous tissue experimental samples, mRNA tissues paracancerous...
4554 Background: Patients with advanced metastatic urothelial carcinoma (UC) who experience disease progression after standard therapy have limited treatment options. Phase I studies of toripalimab in subjects heavily pretreated UC demonstrated an acceptable safety profile and promising clinical activity. Here we report the preliminary efficacy result a phase II study Chinese patients refractory/metastatic carcinoma. (Clinical trial ID: NCT03113266). Methods: Metastatic will receive...
4566 Background: Patients with advanced metastatic urothelial carcinoma (mUC) who experience disease progression after standard therapy have limited treatment options. Toripalimab was approved for the 2 nd line of mUC based on a phase II clinical study (POLARIS-03) in Chinese patients (NCT03113266). Here we report two-year efficacy update and biomarker analysis study. Methods: Metastatic UC received toripalimab 3 mg/kg Q2W until progression, unacceptable toxicity or voluntary withdrawal....
Abstract Clear cell renal carcinoma (ccRCC) is the most common type of kidney cancer in adult, and patients with advanced ccRCC are facing limited treatment options. Cell division cycle associated 5 (CDCA5), a key regulator for segregating sister chromatids cycle, has been increasingly reported potential therapeutic target multiple human cancers. However, functional roles CDCA5 remain uncertain. Here we identified that expression was frequently upregulated tumors significantly poor prognosis...
Objective To develop the interacting learning mode in simulative situation on sex and health courses for college students evaluate effect of it.Methods The core curriculum general education was open to all Shanghai Jiao Tong University from Feb.2010 Jun.2011.The imported simulative-situation-learning method.At end semester,the feedbaick suggestion were collected sorted.Results All groups course involved seriously,which included homosexuality students,undesired pregnancy contraception...