A5101942155- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Genetic Syndromes and Imprinting
- EEG and Brain-Computer Interfaces
- Endometriosis Research and Treatment
- Transcranial Magnetic Stimulation Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Immune Cell Function and Interaction
- Medical Research and Treatments
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Gynecological conditions and treatments
- Pain Mechanisms and Treatments
- Pregnancy and preeclampsia studies
- Genomic variations and chromosomal abnormalities
- Sleep and Wakefulness Research
- Cancer Genomics and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Helicobacter pylori-related gastroenterology studies
- Reproductive Health and Technologies
- Insect symbiosis and bacterial influences
- Bone and Joint Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- BRCA gene mutations in cancer
Anhui University
2024
Tang Du Hospital
2017-2024
Air Force Medical University
2015-2024
Tianjin Medical University General Hospital
2018-2024
Tianjin Medical University
2024
Jinan City People's Hospital
2021-2023
Shandong First Medical University
2021-2023
Dalian Municipal Central Hospital
2015-2023
Hunan University
2022
State Key Laboratory of Chemobiosensing and Chemometrics
2022
Although immune checkpoint blockade have demonstrated promising results, their effects on gastric cancer (GC) are under investigation. Understanding the clinical significance of PD1 and its ligands' expression, together with T cell infiltration might provide clues for biomarkers screening in GC immunotherapy. Immunohistochemistry were performed a tissue microarray including 1,014 specimens using PD1, PDL1 PDL2 antibodies. markers CD3 CD8 also stained quantified by automated image analysis....
It is unknown how to use human embryonic stem cell (hESC) effectively treat hearts with postinfarction left ventricular (LV) remodeling. Using a porcine model of LV remodeling, this study examined the functional improvement enhanced delivery combined transplantation hESC-derived endothelial cells (ECs) and smooth muscle (SMCs) fibrin three-dimensional (3D) porous scaffold biomatrix. To facilitate tracking transplanted cells, hESCs were genetically modified stably express green fluorescent...
Abstract Compelling evidence indicates that stress in utero, as manifested by low birth weight (LBW), increases the risk of metabolic syndrome adulthood. Singletons conceived assisted reproductive technology (ART) display a significant increase LBW and ART offspring have different profile starting at birth. Here, used mouse model, we found resulted reduced fetal placental overgrowth embryonic day 18.5 (E18.5). The placentae exhibited histomorphological alterations with defects layer...
To investigate the processing of noxious stimuli within primary somatosensory cortex (SI), we recorded magnetoencephalography following epidermal electrical stimulation (ES) and innocuous transcutaneous (TS) applied to dorsum left hand. TS activated two sources sequentially SI: one in posterior bank central sulcus another crown postcentral gyrus, corresponding Brodmann's areas 3b 1, respectively. Activities from area consisted 20- 30-ms responses. 1 three components peaking at 26, 36 49 ms....
To evaluate the effects of movement on cortical activities evoked by noxious stimulation, we recorded magnetoencephalography following YAG laser stimulation applied to dorsum left hand in normal volunteers. Results present study can be summarized as follows: (1) active ipsilateral side resulted significant attenuation both primary and secondary somatosensory cortices (SI SII) hemisphere contralateral stimulated (cSI cSII). Activity (iSII) was not affected. (2) Active cSII. cSI iSII (3)...
Significance We developed an approach to fine-map large genomic regions that play important roles for malaria parasite resistance in the vector mosquito, Anopheles gambiae . Direct-association studies wild mosquitoes from malaria-endemic areas Africa identified three mutations genes are associated significantly with Plasmodium falciparum infection. confirmed involvement of these infection by silencing them. The discovered will help us understand interactions between and parasites....
Alteration of intrauterine growth trajectory is linked to metabolic diseases in adulthood. In mammalian and, specifically, human species, pregnancies through assisted reproductive technology (ART) are associated with changes trajectory. However, it still unclear how ART alters trajectory, especially reduced fetal early midgestation. this study, using a mouse model, was found that procedures reduce and placental at Embryonic Day 10.5. Furthermore, leads decreased methylation levels H19,...
Antibiotic-resistant bacteria cause a number of infections in hospitals and are considered threat to public health. A strategy suggested curb the development resistant hospital-acquired is antimicrobial cycling, which antibiotic classes alternated over time. This can be compared with mixing programme which, when given two drugs, half physicians prescribe one drug other. mathematical model cycling hospital population setting developed evaluate efficacy an emphasis on reducing emergence...
Abstract Vitrification is increasingly used in assisted reproductive technology (ART) laboratories worldwide, and potential vitrification‐induced risks require further exploration. The effect of vitrification on changes DNA methylation imprinting disorders was investigated E9.5 mouse fetuses placentas. Fetus placental tissues were collected from the natural mating (nautural conception [NC]) group, vitro culture (IVC) group vitrified embryo transfer (VET) group. fetal crown‐rump length at...
Breast cancer develops as a result of multiple gene mutations in combination with environmental risk factors. Causative variants genes such BRCA1 and/or BRCA2 have been shown to account for hereditary nature certain breast cancers. However,other genes, ATM, PALB2, BRIP1, CHEK, BARD1, while lower frequency, may also increase risk. There are few studies examining the role these causative variants. Our study aimed examine clinical and genetic characterization Chinese population. We tested panel...
Abstract Plasmodium invasion of mosquito midguts is a mandatory step for malaria transmission. The roles midgut proteins and parasite interaction during transmission are not clear. This study aims to identify that interact with affect P. falciparum invasion. Based on gene expression profiles protein sequences, 76 secretory highly expressed in up-regulated by blood meals were chosen analysis. About 61 candidate genes successfully cloned from Anopheles gambiae insect cells. ELISA analysis...
Studies of soft tissue composition using computed tomography (CT) scans are often semi-quantitative and based on Hounsfield units (HU) measurements that have not been calibrated with a quantitative CT (QCT) phantom. We describe study to establish the water (H2O) dipotassium hydrogen phosphate (K2HPO4) basis set equivalent densities fat fat-free liver tissue. With this information can be accurately measured from any abdominal scan suitable phantom.Liver content was by comparing single-energy...
Introduction: Recurrent implantation failure (RIF) is a distressing problem in assisted reproductive technology (ART). Immunity plays vital role recurrent occurrence and development, but its underlying mechanism still needs to be fully elucidated. Through bioinformatics analysis, this study aims identify the RIF-associated immune cell types immune-related genes. Methods: The differentially expressed genes (DEGs) were screened based on Gene Expression Omnibus (GEO) datasets. Then, enrichment...
Ulcerative colitis is a chronic nonspecific inflammatory disease that occurs in the colon and rectum. Costus root type of traditional Chinese medicine exhibits antibacterial properties serves an inhibitory role regeneration gut bacteria. However, molecular mechanisms underlying root-mediated improvements ulcerative remain unclear. A complex formula granules was created investigated present study for its therapeutic effects rat model colitis. Ingredient dissolution into water decoction used...