A5026098740- Meat and Animal Product Quality
- Respiratory Support and Mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Natural product bioactivities and synthesis
- Acute Myeloid Leukemia Research
- Obstructive Sleep Apnea Research
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Ovarian function and disorders
- Bone Metabolism and Diseases
- Nerve injury and regeneration
- Proteins in Food Systems
- Abdominal Surgery and Complications
- Immune Response and Inflammation
- Aquaculture Nutrition and Growth
- Mitochondrial Function and Pathology
- Prenatal Screening and Diagnostics
- Neurogenesis and neuroplasticity mechanisms
- Antimicrobial Resistance in Staphylococcus
- Intensive Care Unit Cognitive Disorders
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Polysaccharides and Plant Cell Walls
- Effects and risks of endocrine disrupting chemicals
Chinese Academy of Fishery Sciences
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2025
Capital Medical University
2011-2024
Fujian Medical University
2021-2024
Beijing Tongren Hospital
2011-2024
First Affiliated Hospital of Fujian Medical University
2024
Anhui University of Traditional Chinese Medicine
2024
First People's Hospital of Yunnan Province
2018-2023
Zhejiang Chinese Medical University
2023
National Health and Family Planning Commission
2023
Sorafenib is the most widely used first-line drug for treatment of advanced hepatocellular carcinoma (HCC). Unfortunately, sorafenib resistance often limits its therapeutic efficacy. To evaluate efficacy artesunate against sorafenib-resistant HCC and to investigate underlying pharmacological mechanisms, a "sorafenib related gene-ART candidate target" interaction network was constructed, signaling axis consisting with target AFAP1L2 SRC, downstream FUNDC1-dependent mitophagy identified as...
Side population (SP) cells are involved in the development of multidrug resistance (MDR) human multiple myeloma (MM), due to their cancer stem cell (CSC)‑like phenotypes. ATP‑binding cassette (ABC) drug transporter proteins have been reported be closely associated with MDR leukemia; however, correlation between ABC and progression MM remains unclear. The present study used lines clinical samples determine role subfamily G member 2 (ABCG2) via flow cytometry, reverse...
To validate the hypothesis that fat tissue accumulation adjacent to upper airway contributes a predisposition obstructive sleep apnea (OSA), irrespective of body mass index (BMI), as well investigate effect volume on pharyngeal mechanical loads.Fourteen subjects and 14 controls were enrolled in this study. Pharyngeal anatomy (the retropalatal region retroglossal region) evaluated using magnetic resonance imaging. Whether had segmental closing pressure higher than atmospheric was determined...
This study aimed to evaluate the immunomodulatory effect of polysaccharide from Sinonovacula constricta (SCP-1-1) in RAW264.7 cells. SCP-1-1 with a molecular weight 440.0 kDa consisted glucose and mannose. The assay results showed that could significantly enhance phagocytic ability, NO production, some cytokines (TNF-α, IL-6, IL-1β) secretion cell dose-dependent manner. Western blot analysis demonstrated regulate expression levels key proteins signaling pathways might associated NF-κβ PI3K...
Antarctic krill (Euphausia superba), a shrimp-like marine crustacean, has become beneficial source of high-quality animal protein. Meanwhile, special focus been placed on its potential sensitization issue. In this study, 35 kDa protein was purified and identified to be tropomyosin (AkTM) by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The TM showed strong IgE-binding capacity shrimp/crab-allergic patients' sera, indicating that is the primary allergen in...
Antarctic krill tropomyosin (AkTM) has been shown in mice to cause IgE-mediated food allergy. The objective of this work was investigate the role Notch signaling AkTM-sensitized mice, as well determine changes gut microbiota composition and short-chain fatty acids (SCFAs) allergic mice. An AkTM-induced allergy mouse model built N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) used an γ-secretase inhibitor inhibit activation signaling. Food indices, some key...
To compare the impact of different post-harvest handling methods on volatile and non-volatile compounds, a total 54 live large yellow croakers were subjected to commercial slaughter (CS), spinal cord cutting (SCC), or bleeding (SCCB). The fish samples ice-stored for 72 h, followed by analysis compounds using gas chromatography–ion mobility spectrometry LC-MS-based untargeted metabolomics. results revealed detection 28 organic with 23 being successfully identified, predominantly including...
Adult-onset Still's disease (AOSD) is an immunological disorder that manifests with fever, evanescent rash, leukocytosis, and arthralgia. One of the most severe complications AOSD macrophage activation syndrome, a life-threatening complication characterized by hyperactivation immune system multiorgan dysfunction. This case report describes 24-year-old female who developed syndrome in setting AOSD. Initially, she heterogeneous nonspecific symptoms pharyngitis, lymphadenopathy, migratory...
We sought to investigate the effects of co-grafting neural stem cells (NSCs) with olfactory ensheathing (OECs) on neurological behavior in rats subjected traumatic brain injury (TBI) and explore underlying molecular mechanisms. TBI was established by percussion device made through a weight drop (50 g) from 30 cm height. Cultured NSCs OECs isolated were labeled Hoechst 33342 (blue) chloromethyl-benzamidodialkyl carbocyanine (CM-Dil) (red), respectively. Then, and/or OECs, separately or...
Antarctic krill protein (AKP) was extracted from by an alkali dissolution-isoelectric precipitation method and then it phosphorylated with sodium tripolyphosphate. The (P-AKP) powder obtained spray-drying (SD), freeze-drying (FD), hot-air drying (AD), the effects of these methods on structures functional properties proteins were investigated. P-AKP dried SD had best sensory performance, its particle size much smaller than that FD AD. Scanning electron microscope displayed a uniform particles...
Diabetic osteoporosis (DOP) is a widespread public health problem. The flavonoids of Rhizoma Drynariae (RDF) have clear preventive and therapeutic effect on (OP), but it not yet whether RDF has an anti-DOP its mechanism related to the activation BMP2/Smad signaling pathway. current study aimed this in DOP rats possible involvement pathway activation.Following intragastric administration for 12 weeks, body weight, blood glucose, bone histopathological changes detected by hematoxylin-eosin...
Abstract Objective The objective ofthis study was to assess the association between thyroid hormone (TH) levels in follicular fluid (FF) and serum determine whether THs impact assisted reproductive technology (ART) outcomes. Methods This enrolled 299 women undergoing ART. Blood samples were drawn on day of human chorionic gonadotrophin (HCG) administrationand analysed for thyroid-stimulating (TSH), thyroxine(T4), triiodothyronine(T3),free T4 (fT4),free T3(fT3), peroxidase antibody (TPOAb)...
Background/Aims: To investigate the effects of bone marrow stromal cells (BMSCs) and underlying mechanisms in traumatic brain injury (TBI). Methods: Cultured BMSCs from green fluorescent protein-transgenic mice were isolated confirmed. immediately transplanted into regions surrounding injured-brain site to test their function rat models TBI. Neurological was evaluated by a modified neurological severity score on day before, days 7 14 after transplantation. After 2 weeks BMSC transplantation,...
Abstract Progesterone elevation (PE) on the day of hCG trigger is associated with decreased pregnancy outcome in fresh cycles. Evidence for this comes from overall patient estimates that mostly ignore different ovarian responses. To compare impacts PE live birth rates (LBs) low, intermediate and high responders to explore cut-off value populations according response, we retrospectively analyzed a total 2,351 patients receiving assisted reproduction technology (ART) transfer cycles GnRH...
This study examined the role of bone mesenchymal stem cell (BMSC) and olfactory ensheathing (OEC) cografting on neural function underlying molecular mechanisms in acute stage traumatic brain injury (TBI) rats. Eighty Sprague-Dawley (SD) female rats were randomly divided into five groups ( n = 16 per category): sham operated group (Sham), weight-drop-induced TBI (TBI), BMSC transplantation (BMSC), OEC (OEC), cotransplantation (CO). Eight selected from each for behavioral morphological...
The study is aimed at determining how the quality of Antarctic krill (Euphausia superba) sauce (AkS) changed over time, including changes in color, moisture content, acid value (AV), peroxide (POV), thiobarbituric reactive substance (TBARS), aerobic plate count, and sensory score. Quality variations shelf life AkS were estimated using kinetic model back propagation (BP) neural network model. results showed that score, <a:math xmlns:a="http://www.w3.org/1998/Math/MathML"...