A5062206531- Drug Transport and Resistance Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Arsenic contamination and mitigation
- Drilling and Well Engineering
- Gastroesophageal reflux and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Peroxisome Proliferator-Activated Receptors
- Methane Hydrates and Related Phenomena
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Renal and related cancers
- Trauma Management and Diagnosis
- Transplantation: Methods and Outcomes
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Diabetic Foot Ulcer Assessment and Management
- Reconstructive Surgery and Microvascular Techniques
- CO2 Sequestration and Geologic Interactions
- Industrial Engineering and Technologies
- Helicobacter pylori-related gastroenterology studies
- Sulfur Compounds in Biology
- RNA Research and Splicing
- Cholesterol and Lipid Metabolism
- Tannin, Tannase and Anticancer Activities
- Pregnancy-related medical research
Innovation Team (China)
2024
China Agricultural University
2024
State Key Laboratory of Animal Nutrition
2024
Sichuan University
2020-2023
Shenzhen University
2023
Zhejiang Chinese Medical University
2023
Ministry of Education of the People's Republic of China
2020-2022
China Medical University
2017-2022
Anhui Medical University
2020-2022
Anhui Provincial Hospital
2021
Diabetic osteoporosis (DOP) is a widespread public health problem. The flavonoids of Rhizoma Drynariae (RDF) have clear preventive and therapeutic effect on (OP), but it not yet whether RDF has an anti-DOP its mechanism related to the activation BMP2/Smad signaling pathway. current study aimed this in DOP rats possible involvement pathway activation.Following intragastric administration for 12 weeks, body weight, blood glucose, bone histopathological changes detected by hematoxylin-eosin...
Background: Oxidative damage may contribute to post-stroke cognitive impairment (PSCI), but the underlying mechanisms are not fully elucidated. Dimethyl fumarate (DMF) has been used as an antioxidant in multiple sclerosis and psoriasis patients. We hypothesized that redox state was associated with PSCI, DMF might exert neuroprotective effect against PSCI via anti-oxidative actions. Methods: To confirm this hypothesis, we first conducted a clinical study (NCT03519828) enrolled patients...
Overexpression of <italic>HIF2α via miR-182-5p</italic> suppression is involved in arsenic-induced malignant transformation human renal epithelial cells.
To provide a more accurate evaluation of the scale deep underground resources, new pressure coring system was carefully developed and its strength safety engineering were verified by theoretical analyses numerical simulation. The designed can obtain cores with length 3 m diameter 50 mm at 70 MPa. results ball-drop operation experiment demonstrate that differential motion assembly effectively cut pin applying tensile force 4852 N, it lift core tube through center pole to complete series...
Chronic arsenic exposure is associated with the increased risk of several types cancer, among which, lung cancer most deadly one. Nuclear factor erythroid 2 like 1 (NFE2L1), a transcription belonging to CNC-bZIP family, regulates multiple important cellular functions in response acute arsenite exposure. However, role NFE2L1 induced by chronic unknown. In this study, we firstly showed that (36 weeks) led epithelial-mesenchymal transition (EMT) and malignant transformation human bronchial...
Abstract Arsenic is a common environmental and occupational toxicant with dramatic species differences in its susceptibility metabolism. Mouse strain variability may provide better understanding of the arsenic pathological profile but largely unknown. Here we investigated oxidative lesion induced by acute exposure two frequently used mouse strains C57BL/6J 129X1/SvJ classical gene targeting technique. A dose 5 mg/kg body weight led to significant alteration blood glutathione towards oxidized...
In situ pressure-preserved coring (IPP-Coring) is one of the most efficient methods for identifying scale oil and gas content. However, differential motion assembly IPP-Coring system often undergoes ball seat seal failure sticking due to surface erosion, a greater pressure drop may unexpectedly trigger assembly. This paper addresses these issues by improving hydraulic structure an based on deep understanding flow characteristics in assembly, thus increasing success rate IPP-Coring....
It is difficult to adapt traditional screw motors with rubber stators the high-temperature and high-pressure conditions in ultra-deep wells, where age, deform carbonize, resulting motor failure. In this study, goal develop volumetric power drilling tools that can be used drill at depths of 10,000 m. To meet goal, an all-metal applied wells designed, then its deformation structural design are studied. Through numerical simulation, change clearance after expansion environments characteristics...
ABCA3 (ATP-binding cassette class A3) is a transmembrane transporter that plays positive role in chronic pulmonary inflammation by regulating lipid metabolism. However, it not completely clear whether and its signaling factors are involved induced the combination of CSE (cigarette smoke extract) LPS (lipopolysaccharide). In this study, we used method combining which was widely to study lung inflammation-related diseases has been proven effective our group's studies create vivo vitro models....
BACKGROUND:Hyperglycemia has been confirmed to damage endothelial function of vascular and microvascular. The regulation zinc finger E-box binding protein 2 (ZEB2) on cells (VECs) is reported rarely. Our study investigates the role ZEB2 apoptosis VECs induced by high glucose through MAPK pathway. MATERIAL AND METHODS:Downregulated upregulated expression in human umbilical vein (HUVECs) were performed plasmids transfection. HUVECs are respectively treated with different concentrations (5.5...
Purpose: Hyperbaric oxygen (HBO2) therapy is used to improve the survival of compromised flaps. Compromised flaps are complications encountered postsurgically, or in traumatic degloving avulsion injuries. Failed lead persistence defect, requirement another donor site, and psychosocial sequelae. Although evidence benefit HBO2therapy significant, there no consensus on optimal treatment regimen. The purpose this study examine whether twice-daily treatments (BID HBO2) provide additional compared...
The transporter multidrug resistance protein 2 (MRP2) can transport some tobacco carcinogens and plays an important role in the of mediators related to pulmonary inflammatory diseases. However, it is not fully understood whether inflammation caused by cigarette smoke extract (CSE) lipopolysaccharide (LPS) regulation MRP2. In this study, CSE LPS were used alone combination as stimuli induce inflammation. addition, establishment a model was verified animal experiments vivo. We found that...
Zearalenone (ZEN) is a toxic secondary metabolite produced by the