A5103148103- RNA modifications and cancer
- Cancer Cells and Metastasis
- Solar-Powered Water Purification Methods
- Cancer-related molecular mechanisms research
- Membrane Separation Technologies
- Surface Modification and Superhydrophobicity
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Heat shock proteins research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Water Resources and Sustainability
- Minerals Flotation and Separation Techniques
- Cryospheric studies and observations
- Glutathione Transferases and Polymorphisms
- Liver physiology and pathology
- Water Quality Monitoring Technologies
- Pancreatic and Hepatic Oncology Research
- Microtubule and mitosis dynamics
- Arctic and Antarctic ice dynamics
- Axon Guidance and Neuronal Signaling
- Land Use and Ecosystem Services
- Data-Driven Disease Surveillance
- Cellular Mechanics and Interactions
- COVID-19 epidemiological studies
Donghua University
2023-2025
Sun Yat-sen University
2021-2024
Lanzhou University
2019-2024
First Hospital of Lanzhou University
2022-2024
Chongqing University
2021
University of Electronic Science and Technology of China
2020
Abstract Evidence for the involvement of N 6 -Methyladenosine (m A) modification in etiology and progression liver fibrosis has emerged holds promise as a therapeutic target. Insulin-like growth factor 2 (IGF2) mRNA-binding protein (IGF2BP2) is newly identified m A-binding that functions to enhance mRNA stability translation. However, its role an remains elusive. Here, we observed IGF2BP2 highly expressed activated hepatic stellate cells (HSCs), inhibition protects against HSCs activation...
Abstract 2D photothermal membranes have demonstrated numerous advantages in solar desalination due to their flexibility, scalability, and low cost. However, practical applications are limited by the restricted evaporation area obstructed vapor channels. A biomimetic design of breathable fabric is reported, which composed two carbon‐nanotube‐hydrogel‐coated polyester (PET) fabrics separated fiber pillars, with upper layer having a hole array as stomatal This shows high solar‐absorption...
Abstract Background Accumulating evidence demonstrates that tRFs (tRNA-derived small RNA fragments) and tiRNAs stress-induced RNA), an emerging category of regulatory molecules derived from transfer RNAs (tRNAs), are dysregulated in various human cancer types play crucial roles. However, their roles mechanisms hepatocellular carcinoma (HCC) liver stem cells (LCSCs) still unknown. Methods The expression glycine tRNA-derived fragment (Gly-tRF) was measured by qRT-PCR. Flow cytometric analysis...
In recent decades, the melting of Greenland Ice Sheet (GrIS) has become one major causes global sea-level rise. Supraglacial lakes (SGLs) are typical hydrological features produced on surface GrIS during melt seasons. The existence and evolution SGLs play an important role in process ice sheet surface. To understand distribution changes Greenland, this study developed a random forest (RF) algorithm incorporating texture morphological to automatically identify based Google Earth Engine (GEE)...
In ecologically fragile areas, an uncontrolled increase in urban development intensity (UDI) will erode the ecological carrying capacity (ECC). This study aimed to explore relationship between UDI and ECC quantify impacts of on ECC. The Three Gorges Reservoir Area (Chongqing section) was chosen for case study. Firstly, were comprehensively evaluated. Then, coupling coordination two analyzed by a degree model. Finally, influences coordinated geographically weighted regression results show...
It has been revealed by our previous proteomic study that the expression profile is different between well‑differentiated and poorly differentiated hepatocellular carcinoma (HCC). Among those differently expressed proteins, peroxiredoxin2 (PRDX2) was protein of interest. The present aimed to further investigate value PRDX2 as a prognostic factor in HCC. Tissue microarrays were used difference HCC tissues their adjacent normal liver tissues. at both mRNA levels examined q‑RT‑PCR, western...
It is generally believed that the existence of cancer stem cells (CSCs) related to tumor recurrence and metastasis hepatocellular carcinoma (HCC). Neuropilin1 (NRP1) involved in numerous pathophysiological processes progression, however, whether NRP1 regulation liver CSCs HCC still unknown. In present study, we examined effect on population mechanism HCC. small hairpin RNA (shRNA)-transduced cells, surface markers (CD133+/ EpCAM+/CD13+/CD44+) expressing which imply population, were...
Forecasting infectious respiratory diseases is crucial for effective prevention and intervention strategies. However, existing time series forecasting models that incorporate human mobility data have faced challenges in making localized predictions on a large scale across the country due to costs constraints. Using COVID-19 pandemic as case study, this research explores whether integrating social media-based place connectivity networks can improve of disease transmission at county level...
When dental pulp needs to be removed in individuals who require root canal therapy, segmentation from cone-beam computed tomography (CBCT) images plays a vital role assisting clinical decisions by making through simulation of removal. Dental has complex topological shapes and inhomogeneous intensity distribution, so we propose level set method incorporate the piecewise area energy with local edge into semiautomatically segment pulps three-dimensional domain. The minimization approximates...
Abstract Evidence for the involvement of N6-Methyladenosine (m6A) modification in etiology and progression liver fibrosis has emerged holds promise as a therapeutic target. Insulin-like growth factor 2 (IGF2) mRNA-binding protein (IGF2BP2) is newly identified m6A-binding that functions to enhance mRNA stability translation. However, its role an remains elusive. Here, we observed IGF2BP2 highly expressed activated hepatic stellate cells (HSCs), inhibition protects against HSCs activation...
Neuropilin-1 (NRP1) is a type I transmembrane glycoprotein that was originally found playing role in neuronal axon guidance and embryonic angiogenesis. NRP1 can promote various aspects of tumorigenesis, such as angiogenesis, cell survival, migration, invasion chemo-resistance, but little known about the nanomechanica signature inregulating hepatocellular carcinoma(HCC) cells. Our study overexpressed HCC high expression associated with poor prognosis patients.but there are no correlation...
Abstract Background: PCGF4 as a cancer stem cells (CSC) marker displays cell-like properties, and drug resistance in hepatocellular carcinoma (HCC). PCGF2, homologue of PCGF4, the effect PCGF2 on liver CSCs (LCSCs) molecular mechanism this have not been documented. Methods: To measure cell viability, properties cells, Cell Counting Kit-8, spheroid assay, flow cytometry assays were applied HCC lines, respectively. The self-renewal was determined by limiting dilution assay. Also, IHC western...
Abstract Background: The existence of liver cancer stem cells (LCSCs) and the occurrence epithelial-mesenchymal transition (EMT) are generally considered to be primary causes for migration metastasis Hepatocellular carcinoma (HCC). Accumulating evidences demonstrate that tRFs tiRNAs, an emerging category regulatory RNA molecules derived from transfer (tRNA), dysregulated in various human types play crucial roles. However, their impact on tumorigenesis is still exploratory stage, roles...
Abstract Background: PCGF4 is highly expressed in liver cancer and can be used as a marker for stem cells. However, PCGF2, homologue of PCGF4, not clear whether it HCC, regulates the stemness Methods: IHC Western blot were to detect expression PCGF2 protein human HCC tissues cell lines. Flow cytometry sphere formation performed effect or on stem-like properties Kaplan-Meier curves conducted OS DFS. Cell viability was measured at indicated time points using Counting Kit-8. We KEGG analysis...