A5107304181- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Milk Quality and Mastitis in Dairy Cows
- NF-κB Signaling Pathways
- melanin and skin pigmentation
- Probiotics and Fermented Foods
- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Legionella and Acanthamoeba research
- Asthma and respiratory diseases
- Parasitic Diseases Research and Treatment
- Cholesterol and Lipid Metabolism
- Parasites and Host Interactions
- Dermatology and Skin Diseases
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Flavonoids in Medical Research
- Curcumin's Biomedical Applications
- Allergic Rhinitis and Sensitization
- Helminth infection and control
- Cancer Cells and Metastasis
- Phytochemistry and Biological Activities
- IL-33, ST2, and ILC Pathways
- Blood disorders and treatments
- Pomegranate: compositions and health benefits
Justus-Liebig-Universität Gießen
2018-2025
Foshan University
2022-2025
Jilin University
2013-2017
Allergic asthma is a complex inflammatory disease characterized by airway hyperresponsiveness, eosinophilic inflammation and the hypersecretion of mucus goblet cells. Ellagic acid (EA), natural polyphenolic compound present as ellagitannins in fruits fruit juices, has been reported to show potent anti-inflammatory properties various diseases. We aimed investigate effects EA an ovalbumin (OVA)-induced mouse model explore its potential mechanism action. Our results showed that resulted...
Cyanidin-3-O-β-glucoside (C3G) (CAS number 7084-24-4), a typical anthocyanin pigment that exists in the human diet, has been reported to have anti-inflammatory properties. However, effect of C3G on lipopolysaccharide (LPS)-induced mastitis and molecular mechanisms not investigated. In this study, we detected protective effects LPS-induced mouse model investigated LPS-stimulated mammary epithelial cells (MMECs). Our results showed could attenuate histopathologic changes myeloperoxidase...
Heartworm disease is a zoonotic vector-borne caused by Dirofilaria immitis mainly affecting canids. Infectious third-stage larvae (L3) are transmitted to the definitive hosts via culicid mosquitos; adult nematodes reside in pulmonary arteries and right heart releasing unsheathed first stage (microfilariae) into bloodstream leading chronic sometimes fatal disease. So far, early innate immune reactions triggered these different D. stages canine host have scarcely been investigated. Therefore,...
Calicophoron daubneyi infections have increased in Europe, being more frequent than fasciolosis some areas. Infection occurs once definitive hosts ingest encysted metacercariae present on vegetation. Following excystation, juvenile flukes penetrate the small intestinal mucosa and migrate into rumen where adults mature. Throughout somatic migration, juveniles come across different microenvironments tissues encounter host leukocytes. Besides phagocytosis, production of reactive oxygen species...
Abstract Besnoitia besnoiti is an obligate intracellular apicomplexan protozoan parasite, which causes bovine besnoitiosis. Recently increased emergence within Europe was responsible for significant economic losses in the cattle industry due to reduction of productivity. However, still limited knowledge exists on interactions between B. and host innate immune system. Here, bradyzoites were successfully isolated from tissue cysts located skin biopsies a naturally infected animal, we aimed...
Given that B. besnoiti tachyzoites infect host endothelial cells of vessels in vivo, they become potential targets for professional phagocytes [e.g., polymorphonuclear neutrophils (PMN)] when search adequate or case cell lysis. It was recently reported besnoiti-tachyzoites can efficiently be trapped by neutrophil extracellular traps (NETs) released bovine PMN. So far, the role autophagy parasite-triggered NET formation is unclear. Thus, we here analyzed autophagosome and activation...
Besnoitia besnoiti tachyzoites infect and develop in bovine endothelial cells vivo trigger the release of neutrophil extracellular traps (NETs) from polymorphonuclear neutrophils (PMN). The purpose this study was to analyze if pure B. tachyzoite-triggered NETs would damage host subsequently influence intracellular development proliferation primary cells. For comparison purposes, isolated A23187-induced were also used. Thus, we here evaluated cell triggered by histone 2A (H2A)...
The protozoan parasite Eimeria bovis is the causative agent of bovine coccidiosis, an enteric disease global importance that significantly affects cattle productivity. Previous studies showed NETosis—an important early host innate effector mechanism polymorphonuclear neutrophil (PMN)—is elicited by E. stages. So far, metabolic requirements -triggered NET formation are unknown. We here studied glycolytic and mitochondrial responses PMN as well role pH, distinct pathways, P2 receptor-mediated...