A5101630787- Coccidia and coccidiosis research
- Parasitic Infections and Diagnostics
- Veterinary medicine and infectious diseases
- Cancer Research and Treatments
- Helminth infection and control
- Animal Nutrition and Physiology
- Antimicrobial Peptides and Activities
- melanin and skin pigmentation
- Toxoplasma gondii Research Studies
- Parasites and Host Interactions
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bacteriophages and microbial interactions
- Nanoparticle-Based Drug Delivery
- NF-κB Signaling Pathways
- Monoclonal and Polyclonal Antibodies Research
- Skin and Cellular Biology Research
- Mast cells and histamine
- Peptidase Inhibition and Analysis
- Botanical Research and Chemistry
- RNA regulation and disease
- Milk Quality and Mastitis in Dairy Cows
- Pharmacological Effects and Assays
- Insect and Pesticide Research
Jilin University
2011-2025
Jilin Medical University
2009-2021
Harbin Institute of Technology
2019
University of Pittsburgh
2019
Anhui Medical University
2004-2016
Ministry of Education of the People's Republic of China
2013-2016
UPMC Hillman Cancer Center
2012-2016
Henan University of Science and Technology
2016
First Bethune Hospital of Jilin University
2014
Anhui University of Science and Technology
2013
A novel strategy was developed to prepare nanospheres and vesicles as drug carriers. The drug-loaded pectin were fabricated in aqueous media containing Ca2+ CO32− ions under very mild conditions, which did not involve any surfactant. Through adjusting the preparation nanosized delivery systems with diverse morphologies, that is, vesicles, could be obtained. This technique offer good control over morphology size of vesicles. morphologies aggregates observed by environmental scanning electron...
IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP+) NADPH and participates in the citric acid cycle for energy production. Notably, this gene has been shown be critical cell proliferation. The abnormal expression of reported several types cancer, mutations have identified gliomas acute myelogenous leukemia. overexpression endometrial, prostate testicular cancer as well Kashin-Beck...
An experimental investigation of the breakup ${(\mathrm{C}{\mathrm{O}}_{2})}^{3+}$ induced by $\mathrm{N}{\mathrm{e}}^{4+}$ ion impact at incident energies 1.12 MeV was performed. By analyzing momentum distributions and kinetic three fragment ions, nonsequential sequential dissociation mechanisms are verified. In contrast to highly charged impact, two different decay pathways were observed in present experiment. One pathway originates from primary cation populated into...
Cancer is a frequent disease that seriously harms human health, but there are no ideal therapies for it. Currently, some food-grade microorganisms such as Lactobacillus plantarum have shown better anti-tumor effects. Here, recombinant lives vector vaccine NC8-sHSP was generated by using the invasive NC8 expressing FnBPA to deliver associated antigen gene sHSP between trichinella spiralis and Lewis lung cancer cells (LLC) host cells. colonized mouse intestine plasmids intestinal epithelial...
A novel recombinant Bacille Calmette-Guerin (rBCG) vaccine co-expressed Eimeria tenella rhomboid and cytokine chicken IL-2 (chIL-2) was constructed, its efficacy against E. challenge observed. The gene of chIL-2 were subcloned into integrative expression vector pMV361, producing vaccines rBCG pMV361-rho pMV361-rho-IL2. Animal experiment via intranasal subcutaneous route in chickens carried out to evaluate the immune vaccines. results indicated that these could obviously alleviate cacal...
Dyschromatosis symmetrica hereditaria (DSH) is a pigmentary genodermatosis of autosomal dominant inheritance characterized by mixture hyperpigmented and hypopigmented macules distributed on the dorsal aspects hands feet. It caused mutations RNA-specific adenosine deaminase gene. We report identification Chinese family with three-generation pedigree DSH, in whom novel tyrosine substitution mutation DSRAD was demonstrated: heterozygous nucleotide A→G transition at position 2879 exon 10 gene detected.
Pattern recognition receptors (PRRs) can recognize pathogen-associated molecular patterns and activate downstream signalling pathways, resulting in modulation of host immunity against pathogens. Here, we investigated whether PRR-mediated is involved immune responses to the blood-feeding nematode Haemonchus contortus. During blood-feeding, H. contortus secretes immune-modulating antigens into blood. Therefore, stimulated sheep peripheral blood mononuclear cells (PBMCs) with soluble extract...
Abstract Background Trichinella spiralis ( T. ) is a parasite occurring worldwide that has been proven to have antitumour ability. However, studies on the effects of cross antigens between tumour and or antibodies against tumours are rare. Methods To study role osteosarcoma spiralis, we first screened cDNA expression library muscle larvae obtain antigen gene protein D52 TPD52 ), prepared fusion its antiserum. The anti-osteosarcoma effect anti-TPD52 antiserum was studied using cell...
It has been shown that many antihistamines may have anti-inflammatory activity in addition to being H1 antagonists. Mizolastine (MIZ), a novel antihistamine, might also anti-angiogenesis properties. In this study, we investigated the influence of MIZ on proangiogenesis factors, vascular endothelial cell growth factor (VEGF), tumour necrosis (TNF)-alpha and keratinocyte-derived chemokine (KC) murine mast cells by using ELISA RT-PCR, as compared with dexamethasone (DEX) loratadine (LOR). Our...
Invasion in several apicomplexan parasites, including Eimeria tenella, is accompanied by shedding of surface adhesins intramembrane proteolysis mediated rhomboid protease. We have previously identified E. tenella 3 (EtROM3), but its precise role has not been elucidated. In this study, the interactions between EtROM3 and microneme (MIC) proteins were analyzed using yeast two hybrid technique. The results showed that c-Myc-ROM3 fusion protein interacted with EtMIC4 co-transformed AH109 yeasts,...