A5016887592- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Heat shock proteins research
- Extracellular vesicles in disease
- RNA modifications and cancer
- Hip disorders and treatments
- Osteoarthritis Treatment and Mechanisms
- Cancer-related Molecular Pathways
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Genomics and Chromatin Dynamics
- Bone Metabolism and Diseases
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- RNA regulation and disease
- Orthopaedic implants and arthroplasty
- Effects of Radiation Exposure
- Morphological variations and asymmetry
- Pharmacological Effects of Medicinal Plants
- Hops Chemistry and Applications
- Muscle Physiology and Disorders
- Bone and Dental Protein Studies
- Kruppel-like factors research
Shenzhen Second People's Hospital
2020-2024
Shenzhen University Health Science Center
2020-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2024
Ohio University
2018-2022
Biotechnology Institute
2018-2022
Shandong Agricultural University
2021-2022
Chongqing University
2016-2021
Army Medical University
2020
Daping Hospital
2020
Osteoarthritis (OA) is the most common degenerative disease affecting joints, and inflammation appears to play a critical role in initiation progression of OA. Caffeic acid phenethyl ester (CAPE), natural flavonoid compound, has anti‑inflammatory antioxidant functions. However, its effects on OA underlying mechanisms action CAPE treatment remain elusive. Therefore, present study investigated IL‑1β‑stimulated chondrocytes vitro surgically induced rat models vivo. In vitro, reduced expression...
Abstract Skeletal system disease (SSD) is defined as a class of chronic disorders skeletal with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position adenosine in RNA, reversible dynamic modification posttranscriptional mRNA. Evidences suggest that m6A modifications play crucial role regulating biological processes all kinds diseases, such malignancy. Recently studies have revealed most abundant epigentic modification, involved progression SSD. However,...
Cold-inducible RNA binding protein (CIRP) is a newly discovered proto-oncogene. In this study, we investigated the role of CIRP in progression non-small cell lung cancer (NSCLC) using patient tissue samples, cultured lines and animal models.Tissue arrays, IHC HE staining, immunoblotting, qRT-PCR were used to detect indicated gene expression; plasmid siRNA transfections as well viral infection manipulate proliferation assay, cycle analysis, migration invasion soft agar colony formation tail...
Osteoarthritis (OA) is a prevalent chronic degenerative joint disease worldwide. Obesity has been linked to OA, and increased free fatty acid levels (e.g., palmitate) contribute inflammatory responses cartilage degradation. Xanthohumol (Xn), bioactive prenylated chalcone, was shown exhibit antioxidative, anti-inflammatory, anti-obesity capacities in multiple diseases. However, clear description of the preventive effects Xn on obesity-associated OA unavailable. This study aimed assess...
Migration and metastasis of tumor cells greatly contributes to the failure cancer treatment. Recently, extracellular protein secreted acidic rich in cysteine (SPARC) has been reported closely related tumorigenesis. Some articles have suggested that SPARC promoted several highly metastatic tumors. However, there are also some studies shown acted as an antitumor factor. SPARC-induced epithelial-to-mesenchymal transition (EMT) melanoma EMT hepatocellular carcinoma. Therefore, role tumorigenesis...
Adenosine (A)-to-inosine (I) RNA editing is the most prevalent mechanism, in which adenosine deaminase acting on 1 (ADAR1) a major deaminase.Increasing evidence suggests that dysregulation of ADAR1 plays an important role human tumorigenesis, while underlying mechanism remains elusive.Here, we demonstrated was highly expressed ovarian cancer tissues and negatively correlated with progression free survival patients.Importantly, silence repressed cell growth colony formation vitro inhibited...
Background The relationship between gut microbiota and osteoarthritis (OA) occurrence remains unclear. Existing research needs to clearly understand how basal metabolic rate (BMR) regulates this relationship. Therefore, using a two-step bidirectional Mendelian Randomization approach, our study aims investigate whether BMR levels mediate the causal OA. Methods In study, we examined publicly available summary statistics from Genome-Wide Association Studies (GWAS) determine correlation analysis...