A5100685463- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Sleep and related disorders
- Adipose Tissue and Metabolism
- Pharmaceutical studies and practices
- Tryptophan and brain disorders
- Autoimmune Bullous Skin Diseases
- Liver Disease Diagnosis and Treatment
- Sleep and Wakefulness Research
- Inhalation and Respiratory Drug Delivery
- Complementary and Alternative Medicine Studies
- Obesity, Physical Activity, Diet
- Pregnancy and Medication Impact
- Mast cells and histamine
- Human Health and Disease
- Sleep and Work-Related Fatigue
- Acupuncture Treatment Research Studies
- HIV, Drug Use, Sexual Risk
- Chemical Synthesis and Characterization
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Sarcoidosis and Beryllium Toxicity Research
- Clinical Reasoning and Diagnostic Skills
- Nuclear Receptors and Signaling
- Birth, Development, and Health
Boehringer Ingelheim (China)
2019-2025
Affiliated Hospital of Southwest Medical University
2023-2024
Second Affiliated Hospital of Nanchang University
2024
Mianyang Central Hospital
2023-2024
Nanchang University
2024
Southwest Medical University
2023
Affiliated Hospital of Guizhou Medical University
2023
Guiyang Medical University
2023
University of Electronic Science and Technology of China
2023
Peking University
2020-2022
Abstract Effisayil 1 was a multicentre, randomized, double‐blind, placebo‐controlled study of the anti‐interleukin (IL)‐36 receptor monoclonal antibody, spesolimab, in patients presenting with generalized pustular psoriasis (GPP) flare. Previously published data from this revealed that within week, rapid and skin clearance were observed receiving spesolimab versus placebo. In pre‐specified subgroup analysis, efficacy evaluated according to patient demographic clinical characteristics at...
Generalized pustular psoriasis (GPP) is a rare and life-threatening skin disease often accompanied by systemic inflammation. There are currently no standardized or validated GPP-specific measures for assessing severity.To evaluate the reliability, validity responder definitions of Pustular Psoriasis Physician Global Assessment (GPPGA) Area Severity Index (GPPASI).The GPPGA GPPASI were using outcome data from Week 1 Effisayil™ study. The psychometric analyses performed included confirmatory...
Prof. Morita presents the EFFISAYIL® 2 clinical trial, which investigated spesolimab treatment for prevention of GPP flares.
This study sought to illustrate whether urinary strontium levels were related developing chronic kidney disease (CKD) in the United States population.A total of 5,005 subjects identified from National Health and Nutrition Examination Survey 2011-2016. Survey-weighted logistic regression analysis, multivariate linear restricted cubic spline (RCS) plots curve stratified analyses undertaken explicate correlation between CKD.With increase strontium, incidence rate CKD albumin creatinine ratio...
Introduction: Generalized pustular psoriasis (GPP) is a chronic, rare disease characterized by flares of widespread skin pustulation. Intravenous (IV) spesolimab, an anti-interleukin-36 receptor monoclonal antibody, approved for GPP flare treatment; however, the optimal dosing and long-term efficacy subcutaneous (SC) spesolimab treatment in patients with has not yet been reported. We report effect SC on achieving sustained remission Effisayil 2 (NCT04399837), 48-week trial that evaluated...
Abstract Background Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disease associated with considerable patient burden. The Psoriasis Symptom Scale (PSS), Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT‐Fatigue) and pain‐Visual Analogue (pain‐VAS) are patient‐reported outcomes (PROs) that have not yet been validated in patients GPP. Objectives To evaluate the psychometric properties PSS, FACIT‐Fatigue pain‐VAS using data from Effisayil 1,...
Esketamine provides an immediate and noticeable antidepressant effect, although the underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been implicated in alleviation of depressive symptoms, whether irisin expression responds to administration esketamine remains unknown. In this study, we found that was reduced hippocampus peripheral blood chronic unpredictable mild stress (CUMS) mice, whereas level rescued treatment. The reduction PGC-1α (transcriptional...
Purpose: Asthma affects approximately 30 million patients in China; however, tiotropium data for Chinese is limited.This study aimed to assess the efficacy and safety of with moderate symptomatic asthma.Methods: A post hoc subgroup analysis was conducted on 430 pooled from two 24-week, replicate phase 3 trials (NCT01172808 NCT01172821), which they received once-daily 2.5 µg (Tio R2.5) or 5 R5) (n = 106 109, respectively), twice-daily salmeterol 50 (Sal 50) 110), placebo 105), while...
Introduction: Generalized pustular psoriasis (GPP) is characterized by flares of widespread pustulation and erythema that may be fatal. Spesolimab, an anti-interleukin-36 receptor monoclonal antibody, approved to treat GPP flares. Effisayil 2 trial (NCT04399837) assessed efficacy safety spesolimab for prevention over 48 weeks. Here we show the high-dose subcutaneous (SC) flare in prespecified subgroups 2.
 Methods: Eligible patients were randomized 1:1:1:1 receive placebo, or low- (300...
Introduction & Objectives: Generalized pustular psoriasis (GPP) is a chronic, rare and potentially life-threatening skin disease, characterized by flares of sterile pustules. Spesolimab, an anti-interleukin-36 receptor monoclonal antibody, effective approved treatment for GPP in adults. Effisayil 2 (NCT04399837) was pivotal, randomized controlled trial that evaluated the efficacy safety subcutaneous spesolimab preventing flares. Here, we report effect high-dose versus placebo on...
The abundant expression of circular RNAs (circRNAs) in the central nervous system and their contribution to pathogenesis depression suggest that circRNAs are promising therapeutic targets for depression. This study explored role mechanism circKat6b esketamine's antidepressant effect. We found intravenous administration esketamine (5 mg/kg) treatment decreased astrocytes hippocampus induced by a chronic unpredictable mild stress (CUMS) mouse model, while overexpression significantly...
Introduction: Generalized pustular psoriasis (GPP) is a chronic, rare and potentially life-threatening disease characterized by flares of widespread skin pustulation. Sustained clearance key treatment objective. Intravenous (IV) spesolimab, an anti-interleukin-36 receptor monoclonal antibody, approved for GPP flare treatment; however, the optimal dosing long-term efficacy subcutaneous (SC) spesolimab in patients with has not yet been reported. We report effect SC on achieving sustained...
What is this study about? Generalized pustular psoriasis (shortened to GPP) a rare, potentially life-threatening disease in which pus-filled blisters or pustules may suddenly form all over the body. The drug spesolimab has been approved treat worsening GPP (known as flares) many countries. However, it was not known if could prevent symptoms of GPP. This summary reports results from clinical called Effisayil™ 2, that done understand safe and effective way flares people with In study, 123...
The association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.
Chronic obstructive pulmonary disease (COPD) is one of the major causes morbidity and mortality worldwide in China. For patients with more severe symptoms, initial treatment long acting β2-agonists long-acting muscarinic antagonists combination therapy recommended. Tiotropium + olodaterol fixed-dose (Tio Olo FDC) an aqueous solution tiotropium bromide delivered by RESPIMAT® Soft Mist™ inhaler for moderate to very COPD. This single site, open-label, phase Ib clinical study assessed...