A5102777365- Intensive Care Unit Cognitive Disorders
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Adipose Tissue and Metabolism
- Transplantation: Methods and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Eicosanoids and Hypertension Pharmacology
- MicroRNA in disease regulation
- Nicotinic Acetylcholine Receptors Study
- Acute Kidney Injury Research
- Nitric Oxide and Endothelin Effects
- Hydrogen's biological and therapeutic effects
- Mycobacterium research and diagnosis
- Hemodynamic Monitoring and Therapy
- Airway Management and Intubation Techniques
- Immune Response and Inflammation
- Neuroscience and Neural Engineering
- Signaling Pathways in Disease
- Cancer Genomics and Diagnostics
- Retinoids in leukemia and cellular processes
- Thermal Regulation in Medicine
- Case Reports on Hematomas
- Pleural and Pulmonary Diseases
- Circular RNAs in diseases
Southwest Medical University
2012-2025
Affiliated Hospital of Southwest Medical University
2016-2024
Southern Medical University
2019
Nanfang Hospital
2019
West China Hospital of Sichuan University
2017
Sichuan University
2017
First Affiliated Hospital of Sichuan Medical University
2012
Zhongshan Ophthalmic Center, Sun Yat-sen University
2010
Sepsis is a serious and elusive syndrome caused by infection, which accompanied high mortality worldwide. Recent evidence has documented the regulatory role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) during inflammatory process, effects in development sepsis have become focus current study. An vivo mouse model vitro cell induced lipopolysaccharide (LPS) were developed. High expression lncRNA MALAT1 along with low breast cancer...
Intestinal ischemia/reperfusion (II/R) is a common and grave clinical event, with high morbidity mortality which can cause cerebral dysfunctions. There are no ideal prevention treatment measures yet. The present study aimed to determine whether muscle-derived factors alleviate gut-associated dysfunctions (GACD) following II/R. We measured the tibialis anterior muscle thickness irisin levels in patients without cognitive dysfunction cardiopulmonary bypass surgery, calculating correlation...
Global cerebral ischemia/reperfusion (GCI/R) injury poses a risk for cognitive decline, with neuroinflammation considered pivotal in this process. This study aimed to unravel the molecular mechanisms underlying GCI/R and propose potential therapeutic strategy associated deficits. Utilizing bioinformatics analysis of public microarray profile (GSE30655 GSE80681) ischemic mice, it was observed that emerged as significant gene ontology item, an increase expression thioredoxin-interacting...
The aging global population is increasing the attention to cognitive decline in older individuals.
Sepsis is a systemic inflammatory response syndrome resulting from infection. This study aimed at exploring the role of microRNA-140 (miR-140) in septic mice. Wnt family member 11 (WNT11) was verified to be target gene miR-140 after bioinformatic prediction and dual luciferase reporter assay. Importantly, negatively regulated WNT11. We initially induced model sepsis by endotoxin, then ectopic expression knockdown experiments were performed explore functional sepsis. Additionally,...
Our previous study showed that the plasma microRNA-221-3p level could serve as a biomarker for major depression or mood. This aimed to further investigate role of in postoperative cognitive dysfunction (POCD). Patients undergoing non-cardiac surgery were randomly assigned according inclusion and exclusion criteria. POCD was diagnosed by Z score method. The relative decided quantitative real-time polymerase chain reaction. Multiple logistic regression analysis receiver operating...
The present study aimed to examine the hypothesis that vascular endothelial growth factor (VEGF) has a protective effect against cardiopulmonary bypass (CPB)-associated acute kidney injury (AKI). Eighteen male beagles were randomly allocated three groups (n=6 per group): Sham group, animals received sternotomy without going through CPB; CPB only; VEGF and VEGF. infusion was completed 1 h prior initiation of CPB. Renal microcirculation perfusion, serum creatinine (SCr) blood urea nitrogen...
Sepsis is a kind of maladjustment response to bacterial infection and activation coagulation, which can induce neuromuscular dysfunction. However, there scarce experimental evidence about the relationship between Schwann cells (SCs) sepsis in We therefore set out identify potential role SCs sepsis-induced dysfunction explore underlying molecular mechanism.Primary were isolated from left hind limb sciatic nerve mice, was constructed by cecal ligation puncture. Then, infected with adenovirus...
the-application-potential-of-the-regulationof-tregs-function-by-irisin-in-the-prevention-and
To test the hypothesis that patient-controlled analgesia (PCA) contributes to improvement of hemorheology in patients undergoing hip arthroplasty.120 patients, aged 60 - 75 years old, arthroplasty under spinal anesthesia, were randomly divided into group PCA (n = 60) and control 60). Patients received postoperative 3 days. Blood samples from median cubital vein collected at five time points: before anesthesia (T1), after surgery (T2), 6 h (T3), 24 (T4), 48 (T5). Hemorheological parameters...
Background: Sepsis is a serious and elusive syndrome caused by infection, which accompanied high rate of mortality worldwide. Studies have speculated the role long non-coding RNAs (lncRNAs) in sepsis. However, potential metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) sepsis largely unknown. Thus, present study intended to investigate possible MALAT1 relation development explore underlying mechanism.Methods: In vivo mouse model vitro cell induced lipopolysaccharide (LPS) were...
Abstract Intestinal ischemia/reperfusion (II/R) injury is a highly-lethal clinical problem and communication between intestine-brain axis vital. Unfortunately, the mechanisms underlying changes are yet unclear. The present study aimed to determine whether FNDC5/irisin plays role in progressive cerebral cognitive deficit following II/R reveal mechanisms. Herein, II/R-treated knockout mice models demonstrated that deficiency aggravates deficit, pro-inflammation microglia activation, oxidative...
Objective To evaluate the role of up-regulated expression α7 nicotinic acetylcholine receptor (α7nAChR) in skeletal muscle decrease sensitivity to vecuronium mice. Methods Eighteen healthy male wild-type C57BL/6J mice, aged 10-12 weeks, weighing 22-30 g, were randomly divided into 3 groups (n=6 each) using a random number table: control group (group C), sham operation S), and joint immobilization I). Eighteen Chrna7tm1Bay/J-knockout α7-/-C), α7-/-S), α7-/-I). The mice anesthetized...
Abstract The perioperative management of a patient with large anterior mediastinal mass is one the major challenges for anesthesia care providers. If there significant tracheal compression or presents difficult breathing, particularly in supine position, awake fiberscope intubation usually indicated order to avoid complete obstruction after induction. Here, we report cervical and mass, along but no even position. After intubation, nearly “cannot intubate cannot ventilate” was encountered....