A5114462017- Traditional Chinese Medicine Studies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects of Natural Compounds
- Magnesium in Health and Disease
- Dermatology and Skin Diseases
- Renal Diseases and Glomerulopathies
- Vitamin C and Antioxidants Research
- Medicinal Plants and Neuroprotection
- Medical Research and Treatments
- Urticaria and Related Conditions
- Parathyroid Disorders and Treatments
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Clinical Nutrition and Gastroenterology
- Hippo pathway signaling and YAP/TAZ
- Ion Channels and Receptors
- Heme Oxygenase-1 and Carbon Monoxide
- Nephrotoxicity and Medicinal Plants
- Genetic and Kidney Cyst Diseases
- Kidney Stones and Urolithiasis Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Pancreatitis Pathology and Treatment
- Esophageal Cancer Research and Treatment
Nanjing University of Chinese Medicine
2012-2024
Jiangsu Province Hospital
2014-2023
Nanjing University
2011-2020
Nanjing Traditional Chinese Medicine Hospital
2011-2020
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2008-2012
Targeting the gut microbiota may become a new therapeutic to prevent and delay progression of chronic kidney disease (CKD). Nonetheless, causal relationship between specific intestinal flora CKD is still unclear.To identify genetically predicted microbiota, we used summary data from genome-wide association studies on in 18340 participants 24 cohorts. Furthermore, 211 microbiotas six phenotypes (outcomes) (CKD, estimated glomerular filtration rate (eGFR), urine albumin creatinine ratio...
Background/Aims: To investigate the effect of Astragaloside IV (AS-IV) on regulation TGF-β1/Smad signaling pathway in peritoneal mesothelial cells with an epithelial-to-mesenchymal transition (EMT). Methods: EMT human (HMrSV5) was induced using 2 ng/ml TGF-β1. Cells were randomly divided into a vehicle group, group AS-IV, TGF-β1 treated and receiving varied doses AS-IV or NAC. Real-time quantitative PCR western blot used to detect expression genes proteins associated EMT. DCFH-DA generation...
Peritoneal fibrosis (PF) is a frequent complication caused by peritoneal dialysis (PD). mesothelial cells (PMCs), the first barrier of peritoneum, play an important role in maintaining structure and function peritoneum during PD. Mesothelial-mesenchymal transition (MMT) oxidative stress PMCs are two key processes PF.To elucidate efficacy possible mechanism asiaticoside inhibition MMT ROS generation TGF-β1-induced PF human (HPMCs).MMT HPMCs were induced TGF-β1. To explain anti-MMT antioxidant...
Inflammation and transforming growth factor-β1 (TGF-β1) contribute to the development of peritoneal fibrosis (PF), which is associated with dialysis (PD). Astragalus membranaceus (Astragalus) has anti-inflammatory anti-fibrotic effects in many diseases. The goal this study was determine on PF response PD. A rat model PD induced using standard fluid, verified by HE Masson’s staining, as well through expression fibroblast surface protein (FSP) collagen III. levels monocyte chemoattractant...
Abstract Chronic kidney disease (CKD) is a with decreased, irreversible renal function. Pruritus the most common skin symptom in patients CKD, especially end‐stage disease. The underlying molecular and neural mechanism of CKD‐associated pruritus (CKD‐aP) remains obscure. Our data show that level allantoin increases serum CKD‐aP CKD model mice. Allantoin could induce scratching behavior mice active DRG neurons. calcium influx action potential reduced significantly neurons MrgprD KO or TRPV1...
Angiogenesis of human peritoneal vascular endothelial cells (HPVECs), linked to growth factor (VEGF)/VEGF receptor 2 (VEGFR2) signaling, is a complication fibrosis (PF). Hippo/YAP signaling interacts with VEGF/VEGFR2 but the effect on angiogenesis and PF has not been studied. We tested VEGF/Hippo/YAP inhibition by tetramethylpyrazine (TMP) in mice HPVECs. This treatment ameliorated dialysis (PD)–induced PF. In mice, was associated upregulation VEGF, TMP submesothelial fibrosis, perivascular...
Peritoneal fibrosis (PF) is a disease caused by prolonged exposure of the peritoneum to high levels dialysis fluid. Astragalus total saponins (ATS) phytochemical naturally occurring in Radix Astragali that has anti-inflammatory and anti-oxidant properties. In this study, we constructed an vivo model PF using 4.25% glucose-containing administered intraperitoneally rats incubated peritoneal mesothelial cells (PMCs) with fluid construct vitro PF. Furthermore, siRNA PGC-1[Formula: see text] was...
Acute kidney injury (AKI) is a global public health hazard with high morbidity and mortality. Sepsis accounts for nearly half of all causes AKI. Scientists have made great effort to explore effective therapeutic agents limited side effects in the treatment AKI, but had little success. With development gut flora study, Akkermansia muciniphila (A. muciniphila) has been proven prevent different organs by regulating inflammatory response. However, reno-protective function still unknown. Here,...
Long-term peritoneal dialysis (PD) causes structural and functional alterations of the membrane. Peritoneal deterioration fibrosis are multicellular multimolecular processes. Under stimulation by deleterious factors such as non-biocompatibility PD solution, various cells in abdominal cavity show differing characteristics, secretion different cytokines, varying protein expression levels, transdifferentiation into other cells. In this review, we discuss role their interactions pathogenesis PD....
The epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) is a crucial event in the induction fibrosis (PF), which canonical Wnt/β-catenin signaling participates. Smads reported to interact with β-catenin and synergistically regulates EMT. This study was aimed reveal effect Astragalus on EMT PMCs.To obtain role EMT, gene transfer into HMrSV5 cell line rats has been achieved. After treatment, markers pathway-related indicators were detected by western blotting,...
It is generally considered that traditional Chinese medicine (TCM) therapy postpones the progression of some chronic kidney diseases (CKDs). herbs are widely applied in TCM therapy. We aimed to evaluate clinical efficacy and safety herbal formula granules patients with CKD stage 3 through a prospective randomized controlled study.A total 343 participants were recruited from 9 hospitals Jiangsu Province between April 2014 October 2016. Participants randomly assigned treatment or control...
As a potential source of myofibroblasts, pericytes may play role in human peritoneal fibrosis. The culture primary vascular animals has previously been reported, most which are derived from cerebral and retinal microvasculature. Here, the field dialysis, we describe method to isolate characterize mouse microvascular pericytes. mesenteric tissues five mice were collected digested by type II collagenase I DNase. After cell attachment, fluid was replaced with pericyte-conditioned medium....
Abstract Objective This study aimed to investigate the efficacy of Chinese herb Cistanche Yishen granules (CYG) in treatment tinnitus for patients with chronic nephritis. Methods A total 89 adult were diagnosed glomerulonephritis from January 2016 December 2017. All randomly divided into two groups, such as control group and CYG group. The was determined using handicap inventory (THI), Pittsburgh sleep quality index (PSQI), pure tone audiometry (PTA), speech reception threshold (SRT), visual...
Abstract Purpose This study aims to investigate whether pretreatment with bone marrow mesenchymal stromal cells (BMSCs) and Astragalus polysaccharide (APS) can enhance their capacity engraft in the peritoneum after vitro transplantation, thereby strengthening anti-fibrotic effect of BMSCs elucidating possible mechanisms involved. Methods Forty male SD rats were randomly divided into control, PDF, PDF + APS group, establish rat peritoneal fibrosis models. The homing effects fluorescently...
Abstract Chronic kidney disease is a with decreased, irreversible renal function. Pruritus the most common skin symptom in patients chronic disease, especially end-stage (AKA disease-associated pruritus [CKD-aP]); however, underlying molecular and neural mechanism of CKD-aP remains obscure. Our data show that level allantoin increases serum CKD model mice. Allantoin could induce scratching behavior mice active DRG neurons; calcium influx action potential were significantly reduced neurons...