A5073965508- Chronic Kidney Disease and Diabetes
- Inflammasome and immune disorders
- Acute Kidney Injury Research
- Pediatric health and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Chronic Disease Management Strategies
- Folate and B Vitamins Research
- Botanical Studies and Applications
- Pharmacology and Obesity Treatment
- Natural Antidiabetic Agents Studies
- Advanced optical system design
- Heme Oxygenase-1 and Carbon Monoxide
- Blood Pressure and Hypertension Studies
- Gut microbiota and health
- Dialysis and Renal Disease Management
- Potassium and Related Disorders
Xidian University
2024
Northwest Institute of Mechanical and Electrical Engineering
2024
Nanjing University of Chinese Medicine
2022-2023
Jiangsu Province Hospital
2022-2023
Targeting the gut microbiota may become a new therapeutic to prevent and delay progression of chronic kidney disease (CKD). Nonetheless, causal relationship between specific intestinal flora CKD is still unclear.To identify genetically predicted microbiota, we used summary data from genome-wide association studies on in 18340 participants 24 cohorts. Furthermore, 211 microbiotas six phenotypes (outcomes) (CKD, estimated glomerular filtration rate (eGFR), urine albumin creatinine ratio...
Acute kidney injury (AKI) is a global public health hazard with high morbidity and mortality. Sepsis accounts for nearly half of all causes AKI. Scientists have made great effort to explore effective therapeutic agents limited side effects in the treatment AKI, but had little success. With development gut flora study, Akkermansia muciniphila (A. muciniphila) has been proven prevent different organs by regulating inflammatory response. However, reno-protective function still unknown. Here,...
The yolk shell is widely used in optoelectronic devices due to its excellent optical properties. Compared single metal nanostructures, shells have more controllable degrees of freedom, which may make experiments and simulations complex. Using neural networks can efficiently simplify the computational process shell. In our work, relationship between size absorption efficiency yolk-shell structure established using a backpropagation network (BPNN), significantly simplifying calculation while...
Objective Chronic kidney disease (CKD) patients are more likely to die from cardiovascular (CVD) than develop renal failure. This study aimed a new nomogram for predicting the risk of death in CKD patients. Methods enrolled 1656 NHANES 2003 2006 survey. Data sets 2005 survey population were used build death, and was validated using data 2004 population. To identify main determinants we performed univariate analysis backward-stepwise regression select key factors. The probability each patient...
Abstract The NLRP3 inflammasome is a component of the innate immune system that plays crucial role in pathophysiology multiple metabolic diseases. But so far, no marketed drugs specifically targeting have been approved. Here, we report characterization GS8-164, potent and selective inhibitor with new phthalazine skeleton. In vitro, GS8-164 displayed inhibition IL-1b production THP-1, human PBMC whole blood assays without inhibiting either IL-6 or TNF-α. vivo, strongly inhibited IL-1β an...
The risk of death significantly increased from stage 3 chronic kidney disease (CKD) onward. We aimed to construct a novel nomogram predict the overall survival (OS) patients afflicted with CKD 3-5.A total 882 3-5 were enrolled NHANES 2001-2004 survey. Data sets 2003-2004 survey population used develop that would OS. 2001-2002 was validate nomogram. Least absolute shrinkage and selection operator (Lasso) regression conducted screen significant predictors relative all-cause death. multivariate...