A5100441030- Luminescence and Fluorescent Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Brain Tumor Detection and Classification
- Neurological Disease Mechanisms and Treatments
- Supramolecular Chemistry and Complexes
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
- Bacillus and Francisella bacterial research
- Click Chemistry and Applications
- Chemical Thermodynamics and Molecular Structure
- Tryptophan and brain disorders
- Ocular Infections and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Ubiquitin and proteasome pathways
- Antibiotic Resistance in Bacteria
- Biosensors and Analytical Detection
- Lanthanide and Transition Metal Complexes
- Carbon and Quantum Dots Applications
- Marine Biology and Environmental Chemistry
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
Chengdu University of Traditional Chinese Medicine
2023-2024
Pohang University of Science and Technology
2019-2024
Hebei University of Technology
2019-2024
Beijing Jiaotong University
2023-2024
Shanghai Electric (China)
2024
Institute for Basic Science
2019-2023
Qufu Normal University
2023
Chinese Academy of Sciences
2022-2023
Fudan University
2023
Southwest Medical University
2022
Abstract While photoluminescence printing is a widely applied anticounterfeiting technique, there are still challenges in developing new generation materials with high security. Here we report the construction of photoresponsive supramolecular coordination polyelectrolyte (SCP) through hierarchical self-assembly lanthanide ion, bis-ligand and diarylethene unit, driven by metal-ligand ionic interaction. Owing to conformation-dependent photochromic fluorescence resonance energy transfer...
Photoinduced electron transfer (PET) is one of the most important mechanisms for developing fluorescent probes and biosensors. Quantitative prediction quantum yields these sensors crucial to accelerate rational development novel PET-based functional materials. Herein, we developed a general descriptor (ΔE) predicting yield PET probes, with threshold value ∼0.6 eV. When ΔE < eV, low (mostly <2%) due substantial activation in polar environments; when > high because inhibition PET. This simple...
Viscosity in the intracellular microenvironment shows a significant difference various organelles and is closely related to cellular processes. Such microviscosity live cells often mapped quantified with fluorescent molecular rotors. To enable rational design of viscosity-sensitive rotors, it critical understand their working mechanisms. Herein, we systematically synthesized investigated two sets BODIPY-based rotors study relationship between intramolecular motions viscosity sensitivity....
The rapid and sensitive classification of bacteria is the first step bacterial community research treatment infection. Herein, a fluorescent probe BacGO presented, which shows best universal selectivity for Gram-positive among known probes with minimum staining procedure sample detection enrichment live bacteria. could also be used to assess Gram status in from wastewater sludge. Furthermore, sensitively selectively detect infection, not only vitro but using an vivo keratitis mouse model....
Neuroinflammation and the NACHT, LRR, PYD domains-containing protein 3 inflammasome play crucial roles in secondary tissue damage following an initial insult patients with traumatic brain injury (TBI). Maraviroc, a C-C chemokine receptor type 5 antagonist, has been viewed as new therapeutic strategy for many neuroinflammatory diseases. We studied effect of maraviroc on TBI-induced neuroinflammation. A moderate-TBI mouse model was subjected to controlled cortical impact device. Maraviroc or...
Abstract Macrophages play crucial roles in protecting our bodies from infection and cancers. As macrophages are multi-functional immune cells, they have diverse plastic subsets, such as M1 M2, derived naïve M0 cells. Subset-specific macrophage probes essential for deciphering monitoring the various activation of macrophages, but developing has been challenging. Here we report a fluorescent probe, CDr17, which is selective over M2 or M0. The staining mechanism CDr17 explicated Gating-Oriented...
Rationale: Neuroinflammation is a primary feature of Alzheimer's disease (AD), for which an increasing number drugs have been specifically developed. The present study aimed to define the therapeutic impact specific subpopulation T cells that can suppress excessive inflammation in various immune and inflammatory disorders, namely, CD4+CD25+Foxp3+ regulatory (Tregs). Methods: To generate Aβ antigen-specific Tregs (Aβ+ Tregs), 1-42 peptide was applied vivo subsequent vitro splenocyte culture....
Abstract Inorganic boric acid (BA) is generally not considered an efficient afterglow material, and several groups have reported its extremely weak room‐temperature phosphorescence (RTP) in the blue spectral region. It discovered that heat treatment of BA results increased intensity (27‐fold increase) prolonged emission lifetime (from 0.83 to 1.59 s), attributed enhanced through‐space conjugation (TSC) BA. The can be further (≈415 folds) by introducing p‐hydroxybenzoic (PHA), which contains...
Tumor initiating cells (TIC) are resistant to conventional anticancer therapy and associated with metastasis relapse in cancer. Although various TIC markers their antibodies have been proposed, it is limited the use of for vivo imaging or treatment TIC. In this study, we discovered heme oxygenase 2 (HMOX2) as a novel biomarker developed selective small molecule probe TiNIR (tumor cell near infrared). detects enriches functionally active human lung tumors, through photoacoustic property, also...
Since anthrax spores are highly lethal to human beings and animals, also potential biological warfare agents, it is desirable develop simple, robust easy-device sensors that rapid sensitive, can selectively detect the Bacillus biomarker dipicolinic acid (DPA) quantitatively. Herein, we report a ratiometric luminescent "turn-on" sensor via mixing Eu3+ ions, sodium polyacrylate internal luminescence reference in water, which identify quantitatively with outstanding selectivity over aromatic...
Intracellular micro-temperature is closely related to cellular processes. Such local temperature inside cells can be measured by fluorescent thermometers, which are a series of materials that convert the information detectable fluorescence signals. To investigate intracellular fluctuation in various organelles, it essential develop site-specific organelle thermometers. In this study, we new Thermo Greens (TGs), visualize change almost all typical organelles. Through lifetime-based cell...
Mitochondrial inflammation triggered by abnormal mitochondrial division and regulated the Drp1/HK1/NLRP3 pathway is correlated with progression of aging-associated cognitive impairment (AACI). Alpinetin a novel flavonoid derived from Zingiberaceae that has many bioactivities such as antiinflammation anti-oxidation. However, whether alpinetin alleviates AACI suppressing pathway-inhibited still unknown. In present study, D-galactose (D-gal)-induced aging mice BV-2 cells were used, effects on...
Microglia, the brain-resident macrophage, are involved in brain development and contribute to progression of neural disorders. Despite importance microglia, imaging live microglia at a cellular resolution has been limited transgenic mice. Efforts have therefore dedicated developing new methods for detection imaging. Using thorough structure-activity relationships study, we developed CDr20, high-performance fluorogenic chemical probe that enables visualization both vitro vivo. genome-scale...
Single-excitation ratio fluorescent probes have enabled the output signal with high signal-to-noise ratio, but are still plagued technique challenges, including distortion and limited application scenario. Herein, a dual-excitation near-infrared (NIR) probe P1 of coumarin derivatives is constructed, showing ability in visible region tissue penetration depth NIR region. As selectively recognizes ClO–, emission (480 nm) enhanced during recognition process. Meanwhile, (830 conjugated system...
Feature representation is the critical factor for computer-aided Alzheimer's disease (AD) diagnosis. Deep polynomial network (DPN) a novel deep learning algorithm, which can effectively learn feature from small samples. In this work, stacked DPN (S-DPN) algorithm proposed to further improve representation. We then propose multi-modality S-DPN (MM-S-DPN) fuse neuroimaging data and more discriminative robust AD classification. Experiments are performed on ADNI dataset with MRI PET images as...
Trimethyltin (TMT) is a potent neurotoxicant that leads to hippocampal neurodegeneration. Regulatory T cells (Tregs) play an important role in maintaining the immune balance central nervous system (CNS), but their activities are impaired neurodegenerative diseases. In this study, we aimed determine whether adoptive transfer of Tregs, as living drug, ameliorates neurodegeneration TMT-intoxicated mice.CD4+CD25+ Tregs were expanded vitro and adoptively transferred TMT-treated mice. First,...
In recent years, two-photon excited semiconductor quantum dots (QDs) have been the subject of intense investigation due to their long excitation wavelength which helps achieve deeper penetration and higher image resolution in optical bioimaging. this paper, water-soluble CdS QDs were synthesized using a hydrothermal method applied human liver hepatocellular carcinoma (HepG2) cells. The first-principles calculation suggested that S-rich defected structure contributes narrower band gap...
As the causative agent of Glässer’s disease, Glaesserella (Haemophilus) parasuis has led to serious economic losses swine industry worldwide. Due low cross-protection vaccines and increasing antimicrobial resistance G. parasuis, it is important develop alternative approaches prevent infection. Defensins are host defense peptides that have been suggested be promising substitutes for antibiotics in animal production, while porcine β-defensin 2 (PBD-2) a potent peptide discovered pigs. Our...