A5101515570- Ion Channels and Receptors
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Neurobiology and Insect Physiology Research
- Lung Cancer Research Studies
- Tuberous Sclerosis Complex Research
- Vascular Tumors and Angiosarcomas
- Neuroendocrine Tumor Research Advances
- Muscle Physiology and Disorders
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Bone Tissue Engineering Materials
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Ion channel regulation and function
- Network Security and Intrusion Detection
- Cancer, Stress, Anesthesia, and Immune Response
- Genital Health and Disease
- Cardiovascular Health and Risk Factors
- Sodium Intake and Health
- Nanoplatforms for cancer theranostics
- Agronomic Practices and Intercropping Systems
- Multiple and Secondary Primary Cancers
- Colorectal and Anal Carcinomas
- Agroforestry and silvopastoral systems
Institute of Nuclear Medicine & Allied Sciences
2025
Narendra Dev University of Agriculture and Technology
2025
Vellore Institute of Technology University
2025
Cold Spring Harbor Laboratory
2023-2024
Indian Institute of Technology BHU
2024
Banaras Hindu University
2024
Institute of Medical Sciences and Sum Hospital
2023
Amrita Institute of Medical Sciences and Research Centre
2023
Siksha O Anusandhan University
2023
Graphic Era University
2023
Multidrug resistant (MDR) bacteria have emerged as a major clinical challenge. The unavailability of effective antibiotics has necessitated the use emerging nanoparticles alternatives. In this work, we developed carbohydrate-coated bimetallic (Au-AgNP, 30–40 nm diameter) that are nontoxic toward mammalian cells yet highly against MDR strains compared to their monometallic counterparts (Ag-NP, Au-NP). Au-AgNP is much more Gram-negative Escherichia coli and Enterobacter cloacae when most...
Transient receptor potential channel subfamily A member 1 (TRPA1) is a non-selective cationic channel, identified initially as cold sensory receptor. TRPA1 responds to diverse exogenous and endogenous stimuli associated with pain inflammation. However, the information on role of toward T-cell responses remains scanty. In silico data suggest that can play an important in activation process. this work, we explored expression its function T cells. By reverse transcription polymerase chain...
PurposeThe concept of dual-state hyper-energy metabolism characterized by elevated glycolysis and OxPhos has gained considerable attention during tumor growth metastasis in different malignancies. However, it is largely unknown how such metabolic phenotypes influence the radiation response aggressive cancers. Therefore, present study aimed to investigate impact (increased OxPhos) on a human glioma cell line.MethodsModulation mitochondrial electron transport chain was carried out using...
This study investigates the adoption patterns and constraints in production of green fodder crops, including Berseem, Maize, Oat, Sorghum, Upper Gangetic Plains India. Data were collected using pre-structured pre-tested schedules, focusing on districts Moradabad, Rampur, Amroha during agricultural year 2022-23. A multi-stage stratified purposive-cum-random sampling technique was employed to select 180 respondents from two blocks per district based highest acreage. The economic evaluation...
Peripheral smear examination and complete blood count by automated analysers work in tandem to offer a thorough report on the patient’s sample. Information can be communicated more effectively through visual images than numerical data. It facilitates immediate diagnosis of various anemias laboratory staff using. An haematology analyser peripheral correlation. Anemia is prevalent Haematological disorder characterized reduction red cell (RBC) or heamoglobin concentration leading Impaired...
Abstract The transient receptor potential melastatin 8 (TRPM8) is an ion channel that has been widely studied as a cold‐sensitive nociceptor. However, its importance in nonneuronal cells mostly unexplored. Here, we describe the presence and functional significance of endogenous TRPM8, nonselective Ca 2+ ‐channel T cell functions. major pool TRPM8 resides at surface accumulation significantly increases activated cells. activation synergizes with T‐cell (TCR) stimulation to increase CD25, CD69...
Prostate cancer is the most common form of in males and accounts for high related deaths. Therapeutic advancement prostate has not been able to reduce mortality burden cancer, which warrants further research. FRG1 affects angiogenesis cell migration Xenopus, can be a potential player tumorigenesis. In this study, we investigated role progression. Immunohistochemistry was performed determine expression patient samples. perturbation done investigate effect on proliferation, invasion, DU145,...
A major limitation in the bio-medical sector is availability of materials suitable for bone tissue engineering using stem cells and methodology converting stochastic biological events towards definitive as well efficient bio-mineralization. We show that osteoblasts Bone Marrow-derived Mesenchymal Stem Cell Pools (BM-MSCP) express TRPM8, a Ca2+-ion channel critical bone-mineralization. TRPM8 inhibition triggers up-regulation key osteogenesis factors; increases mineralization by osteoblasts....
Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a candidate for FSHD. FRG1 regulates various muscle-related functions, but studies have proposed its role in development and angiogenesis also, where it involved with tumor-associated molecules. Therefore, we decided to look into tumor progression, angiogenesis, impact on cellular properties. Cell proliferation, migration, invasion vitro assays were performed decipher the effect of endothelial epithelial cell functions....
Aims Determining the site of origin a metastatic neuroendocrine tumour (NET) can be challenging and has important prognostic therapeutic implications. An immunohistochemical (IHC) panel consisting TTF1, CDX2, PAX8/PAX6 Islet1 is often employed. However, there significant IHC overlap among different primary sites. Herein, we sought to determine utility including Special AT-rich sequence binding protein-2 (SATB2) in that used for determining NET. Methods Paraffin tissue microarrays 137 NETs...
Abstract Objectives Penile squamous cell carcinomas (PCs) are rare malignancies with a dismal prognosis in metastatic setting; therefore, novel immunotherapeutic modalities an unmet need. One such modality is the immune checkpoint molecule programmed death ligand 1 (PD-L1). We sought to analyze PD-L1 expression and its correlation various clinicopathologic parameters contemporary cohort of 134 patients PC. Methods A PC was studied for immunohistochemistry. The evaluated using combined...
Keratocan is a cornea-specific keratan sulfate proteoglycan found predominantly in the adult vertebrate eye. In human beings, mutations keratocan (KERA) are associated with autosomal recessive cornea plana (CNA2), which characterized by flattened forward convex curvature of cornea. Here, we report novel mutation case bilateral presenting primary angle-closure glaucoma 41-year-old woman from Eastern India.The KERA gene patient and her sons was directly sequenced.Mutational analysis revealed 2...
Multiple molecular subtypes and distinct clinical outcomes in breast cancer, necessitate specific therapy. Moreover, despite the improvements cancer therapy, it remains fifth cause of cancer-related deaths, indicating involvement unknown genes. To identify novel contributors subtype independent therapeutic options, we report reduced expression FRG1 patients, which regulates GM-CSF via direct binding to its promoter. Reduction enhanced EMT increased cell proliferation, migration, invasion,...
Technology has radically altered our way of life. It changed the we think, learn, and communicate. Artificial intelligence, or AI, revealed untapped potential in all economic areas. Banking today is much more advanced than conventional brick-and-mortar branch banking were used to up until recently. Customers waiting line at branches, vouchers, stacks paperwork, bustle, confusion—all things that formerly associated with any bank India— have significantly due increased usage technology Indian...