A5042329149- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Drug-Induced Hepatotoxicity and Protection
- Infectious Diseases and Mycology
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- Sinusitis and nasal conditions
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Antifungal resistance and susceptibility
- interferon and immune responses
- Adipose Tissue and Metabolism
- SARS-CoV-2 detection and testing
- Neurological Disorders and Treatments
- S100 Proteins and Annexins
- Apelin-related biomedical research
- Liver physiology and pathology
University of Hong Kong
2025
University of Hong Kong - Shenzhen Hospital
2025
Huazhong University of Science and Technology
2013-2024
Tongji Hospital
2024
Yan'an Hospital Affiliated To Kunming Medical University
2024
Kunming Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Linyi University
2023
Shanghai Public Health Clinical Center
2020-2021
Abstract BACKGROUND A recent outbreak of SARS-CoV-2 infection occurs mainly in China, with rapidly increasing the number cases (namely COVID-19). Abnormal liver functions are frequently present these patients, here we aimed to clarify clinical features COVID-19-related damage provide some references for treatment. METHODS In this retrospective, single-center study, included all confirmed COVID-19 Shanghai Public Health Clinical Center from January 20 31, 2020. The outcomes were followed up...
Non-alcoholic fatty liver disease (NAFLD) encompasses hepatic steatosis, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. It is the primary cause of chronic disorders, with a high prevalence but no approved treatment. Therefore, it indispensable to find trustworthy therapy for NAFLD. Recently, mounting evidence illustrates that Sirtuin 1 (SIRT1) strongly associated SIRT1 activation or overexpression attenuate NAFLD, while deficiency aggravates Besides,...
Tightly regulated Ca2+ homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of handling, we performed chemical suppressor screen on zebrafish tremblor embryos, which suffer from extrusion defects. Efsevin was identified based its potent activity to restore coordinated contractions in tremblor. We show that efsevin binds VDAC2, potentiates mitochondrial uptake and accelerates transfer intracellular stores into mitochondria. In cardiomyocytes, restricts...
Abstract Ginsenoside Rh2 (G-Rh2) has well-established potent antitumor activity; yet, the effects of G-Rh2 on immune and metabolism regulation in cancer treatment, especially non-small cell lung (NSCLC) remain unclear. We showed that had a synergistic effect with cyclophosphamide (CY) mice NSCLC, improved deficiency caused by CY. Consistently, exhibited no inhibitory tumor growth T cells-deficient nude mice. Furthermore, treatment triggered oxidative decomposition fatty acid (FA), suppressed...
Background: A recent outbreak of SARS-CoV-2 infection occurs mainly in China, with rapidly increasing the number cases (namely COVID-19). Abnormal liver functions are frequently present these patients, here we aimed to clarify clinical features COVID-19-related damage provide some references for treatment. Methods: In this retrospective, single-center study, included all confirmed COVID-19 Shanghai Public Health Clinical Center from January 20 31, 2020. The outcomes were followed up until...
Abstract Methionine enkephalin (MENK), an endogenous opioid peptide, has a role in nervous system, immune and anticancer therapy. Inflammation, metabolism cancer are closely intertwined with each other. This study is to identify the correlation of antitumor effects MENK systemic inflammation, liver metabolism, cells as myeloid-derived suppressor (MDSCs). We established subcutaneous CT26 colon carcinoma model cyclophosphamide-induced immunosuppressive subjected MENK. AML12 MDSCs were used...
Background and Purpose Tacrolimus a first‐line medication used after transplantation can induce β‐cell dysfunction, causing new‐onset diabetes mellitus (NODM). Regenerating islet‐derived protein 3 gamma (Reg3g), member of the pancreatic regenerative gene family, has been reported to improve type 1 by promoting regeneration. We aim investigate role Reg3g in reversing tacrolimus‐induced dysfunction NODM mice. Experimental Approach Circulating REG3A (the human homologue mouse Reg3g) heart...
Aims Anesthesia is related to cognitive impairment and the risk for A lzheimer's disease. Hypothermia during anesthesia can lead abnormal hyperphosphorylation of tau, which has been speculated be involved in anesthesia‐induced impairment. The aim this study was investigate whether maintenance tau phosphorylation level by body temperature control could reverse dysfunction C57BL /6 mice. Methods Eighteen‐month‐old mice were repeatedly anesthetized a 2‐week period with or without temperature,...
Per- and polyfluorinated alkyl substances (PFAS) are deemed as a class of persistent pollutants with chemical toxicities, which cause severe contamination to air, soil, water resources. Advanced depuration materials effective adsorption potency urgently needed address these emerging environmental health issues. Herein, porous pillar[5]arene-based polymers (P-P5APs) were easily prepared via one-step cross-linking reaction between perhydroxylated pillar[5]arene decafluorobiphenyl,...
Pancreatic cancer (PC) is featured with low survival rate and poor outcomes. Herein, we found that the expression of caspase-recruitment domain-containing protein 9 (CARD9), predominantly expressed in innate immune cells, was positively related to prognosis PC patients. CARD9-deficient mice exhibited rapider progression poorer rate. CARD9 knockout decreased dendritic cell (DC) maturation impaired DC ability activate T cells vivo vitro. Adoptive transfer confirmed role deficiency relied on...
Background Lymphoma of the lacrimal sac is rare, often misdiagnosed clinically. This study aimed to investigate imaging features these tumors and provide suggestions aid diagnosis. Methods In this retrospective study, five cases were assessed according magnetic resonance (MRI), computed tomography (CT), pathological findings. All patients underwent MRI contrast-enhanced T1-weighted (CE-T1WI), which four dynamic (DCE) three CT. Results Four one case had a lymphoma in left right medial...
Background: HER2-low breast cancer represents a distinct subgroup with unique clinical characteristics and treatment challenges. Nevertheless, it remains uncertain whether there exists distinction in δKi67 between patients HER2-zero statuses, the prognosis varies among differing HER2 statuses δKi67. Methods: We conducted multi-center retrospective study to investigate correlation alterations Ki67 index following NAC or cancer. 3 cohorts comprising HER2-negative who underwent were included....