A5102886733- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Drug Transport and Resistance Mechanisms
- Tuberous Sclerosis Complex Research
- Eosinophilic Esophagitis
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Amino Acid Enzymes and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Metabolism and Genetic Disorders
- Liver physiology and pathology
- Liver Diseases and Immunity
- Neuroscience and Neuropharmacology Research
- Helicobacter pylori-related gastroenterology studies
- ATP Synthase and ATPases Research
- Bioactive Compounds in Plants
- Cancer, Lipids, and Metabolism
- Pharmacological Effects and Toxicity Studies
- Influenza Virus Research Studies
- Endoplasmic Reticulum Stress and Disease
Shanghai Public Health Clinical Center
2012-2024
Fudan University
2020
Abstract BACKGROUND A recent outbreak of SARS-CoV-2 infection occurs mainly in China, with rapidly increasing the number cases (namely COVID-19). Abnormal liver functions are frequently present these patients, here we aimed to clarify clinical features COVID-19-related damage provide some references for treatment. METHODS In this retrospective, single-center study, included all confirmed COVID-19 Shanghai Public Health Clinical Center from January 20 31, 2020. The outcomes were followed up...
Abstract COVID‐19 has become a global pandemic and garnered international attention. Although the clinical features of COVID‐19‐related liver injury have been investigated, there no reports studies on characteristics patients co‐infected with hepatitis B virus (HBV). This study aimed to evaluate whether SARS‐CoV‐2/HBV co‐infection could influence function disease outcome. All 326 confirmed cases in Shanghai Public Health Clinical Center (The designated hospital Shanghai, China) from 20...
Abstract Background Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant disorder caused by pathogenic variants in either the TSC1 or TSC2 gene. Common manifestations of TSC have been grouped into major and minor clinical diagnostic criteria assessed routine workup. However, case studies point towards existence disease to potential association with malignant tumors. In this study we sought characterize malignancies using large cohort patients. Methods TuberOus SClerosis...
Abstract Background Tuberous sclerosis complex (TSC)-associated neuropsychiatric disorders (TAND) have unique, individual patterns that pose significant challenges for diagnosis, psycho-education, and intervention planning. A recent study suggested it may be feasible to use TAND Checklist data data-driven methods generate natural clusters. However, the had a small sample size from only two countries. Here, we investigated replicability of identifying clusters larger more diverse TOSCA study....
Background: A recent outbreak of SARS-CoV-2 infection occurs mainly in China, with rapidly increasing the number cases (namely COVID-19). Abnormal liver functions are frequently present these patients, here we aimed to clarify clinical features COVID-19-related damage provide some references for treatment. Methods: In this retrospective, single-center study, included all confirmed COVID-19 Shanghai Public Health Clinical Center from January 20 31, 2020. The outcomes were followed up until...
Abstract Background The epidemic of 2019 novel coronavirus (COVID-19) struck China in late December, 2019, resulting about 200000 deaths all over the world. Numerous observational studies have suggested that neutrophil-to-lymphocyte ratio (NLR) and lymphocyte proportion platelet-to-lymphocyte (PLR) are inflammatory markers. Our study aimed to detect role NLR, PLR predicting prognosis COVID-19. Methods Four hundred fifteen consecutive patients were enrolled Shanghai Public Health Clinical...
Mitochondrial calcium uniporter (MCU) plays pleiotropic roles in cellular physiology and pathology that contributes to a variety of diseases, but the role potential mechanism MCU pathogenesis metabolic dysfunction-associated steatohepatitis (MASH) remain poorly understood.
Abstract Background The efficacy of entecavir (ETV) add-on peg-interferon therapy compared with ETV monotherapy in treatment-naïve hepatitis B virus (HBV) patients remains controversial. We investigated whether adding to ongoing treatment leads a better curative effect or not. Methods All have been recruited between August 2013 and January 2015 from the Shanghai Public Health Clinical Center Zhongshan Hospital (China). Eligible HBV ( n = 144) were randomly divided (1:1) receive either 70)...
Abstract Background The epidemic of 2019 novel coronavirus (COVID-19) struck China in late December,2019, resulting about 200000 deaths all over the world. Numerous observational studies have suggested that neutrophil-to-lymphocyte ratio (NLR) and lymphocyte proportion platelet-to-lymphocyte (PLR) are inflammatory markers. Our study aimed to detect role NLR, PLR predicting prognosis COVID-19. Results Four hundred fifteen consecutive patients were enrolled Shanghai Public Health Clinical...
Objective To study the effect of cyclooxygenase-2(COX-2)selective inhibitor Celecoxib on expression P- glycoprotein(P-gp)in brain rats with status epilepticus, in order to assess therapeutic value intractable epilepsy. Methods Sixty adult male SD were randomly divided into blank control group, epilepsy model group and intervention group.The epilepticus was induced by injecting Lithium pilocarpine.Forty-eight included experiment.There 16 each respectively.Immunohistochemical method...
Objective To investigate the relationship among Helicobacter pylori(H.pylori),CD4 positive cells and CD8 in gastric mucosa of AIDS patients with gastritis.Methods Fiftyeight upper abdominal pain were diagnosed chronic gastritis through gastroscopy.The biopsies from them used for H.pylori detection rapid urease test Giemsa staining,pathology examination HE staining,and immunohistochemistry analysis CD4,CD8 Gastric mucosa.And application flow cytometry was peripheral blood CD4 lymphocytes...
Abstract Background and Aim The efficacy of entecavir (ETV) add-on peg-interferon therapy compared with ETV monotherapy in treatment-naïve hepatitis B virus (HBV) patients remains controversial. We investigated whether adding Peg-interferon to ongoing treatment leads a better curative effect or not. Methods Eligible HBV (n=144) were randomly divided (1:1) receive either (n=70) from weeks 26 52 (n=74). Patients followed-up for 2 years. evaluated surface antigen (HBsAg) e (HBeAg)...
Abstract Background and Aim The efficacy of entecavir (ETV) add-on peg-interferon therapy compared with ETV monotherapy in treatment-naïve hepatitis B virus (HBV) patients remains controversial. We investigated whether adding Peg-interferon to ongoing treatment leads a better curative effect or not. Methods Eligible HBV (n=144) were randomly divided (1:1) receive either (n=70) from weeks 26 52 (n=74). Patients followed-up for 2 years. evaluated surface antigen (HBsAg) e (HBeAg)...