A5046237702- Microbial Natural Products and Biosynthesis
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Battery Technologies Research
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Extraction and Separation Processes
- Dermatology and Skin Diseases
- Electrochemical Analysis and Applications
- Psoriasis: Treatment and Pathogenesis
- Cytomegalovirus and herpesvirus research
- Innovation and Socioeconomic Development
- Immune responses and vaccinations
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Ocular Diseases and Behçet’s Syndrome
- Cancer Genomics and Diagnostics
- Fungal Infections and Studies
- T-cell and B-cell Immunology
University of Illinois Urbana-Champaign
2018-2022
Ningbo First Hospital
2022
Shandong Shierming Eye Hospital
2020
China Pharmaceutical University
2016
Abstract Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a promising source of new antimicrobials in the face rising antibiotic resistance. Here, we report scalable platform that combines high-throughput bioinformatics with automated biosynthetic gene cluster refactoring for rapid evaluation uncharacterized clusters. As proof concept, 96 RiPP clusters originate from diverse bacterial phyla involving 383 genes refactored manner using biological foundry success...
In a study of 80 patients suspected ovarian torsion and necrosis admitted to our hospital between January December 2023, we analyzed the results abdominal vaginal ultrasounds with surgical diagnoses as reference. Of cases, 74 were confirmed torsion, accounting for 92.50%, while remaining included ruptured corpus luteum cysts, periapendiceal abscesses, ectopic pregnancies, each 2 cases. Abdominal ultrasound identified 63 cases 17 non-ovarian whereas 73 7 torsion. The sensitivity, specificity,...
Most native producers of ribosomally synthesized and post-translationally modified peptides (RiPPs) utilize N-terminal leader to avoid potential cytotoxicity mature products the hosts. Unfortunately, machinery peptide removal is often difficult reconstitute in heterologous Here we devised a general method produce bioactive lanthipeptides, major class RiPP molecules, Escherichia coli colonies using synthetic biology principles, where programmed temporally by protease compartmentalization...
// Wei Guo 1 , Dongmei Yu Xin Wang Cheng Luo Yucong Chen Wen Lei Yaoyao Ge Wenyao Xue Qiqi Tian Xiangdong Gao and Wenbing Yao State Key Laboratory of Natural Medicines, School Life Science Technology, China Pharmaceutical University, Nanjing, Correspondence to: Gao, email: Yao, Keywords : collagen-induced arthritis, IL-23, Th17, Treg, Th9, Immunology Microbiology Section, Immune response, Immunity Received March 09, 2016 Accepted April 28, Published May 11, Abstract IL-23 is an important...
Uveitis is a serious intra-ocular inflammatory disease that can lead to visual impairment even blindness worldwide. Notch signaling regulate the differentiation of naive CD4+ T cells, influencing development uveitis. DNA methylation closely related autoimmune diseases. In this study, we measured Notch1 level, determined and methylases mRNA expression evaluated ratio helper type 17 regulatory cell (Th17/Treg ) in peripheral blood mononuclear cells (PBMCs) from uveitis patients normal control...
Lead acid batteries (LABs) remain an inexpensive energy storage technology with a wide application base. However, their short cycle lifetimes necessitate improved recycling and maintenance technologies to combat various failure modes. One major cause of is hard sulfation, where the formation large PbSO4 crystals on negative active material impedes electron transfer. Here, we introduce protocol remove sulfate deposits electrode while maintaining electrochemical viability for subsequent...
Previous studies have shown that fusion partners a potential role in influencing different tumorigenic abilities of ROS1 variants, as well differential responses to crizotinib. Therefore, it is important accurately identify the type rearrangement NSCLC for clinical treatment selection.Deep-coverage targeting solid tumor 31 cancer-related genes panel was used capture DNA-based NGS information detect gene fusion. RNA based on hybrid sequencing performed verify fusions from total which isolated...