A5108299285- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Bone health and treatments
- Connective tissue disorders research
- Bone Metabolism and Diseases
- Pituitary Gland Disorders and Treatments
- Hip and Femur Fractures
- Glycosylation and Glycoproteins Research
- Dermatological and Skeletal Disorders
- Bone and Joint Diseases
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Medical Imaging Techniques and Applications
- Mosquito-borne diseases and control
- Genital Health and Disease
- Histiocytic Disorders and Treatments
- Bone and Dental Protein Studies
- Genetic Syndromes and Imprinting
- Viral Infections and Vectors
- Medical Imaging and Pathology Studies
- Proteoglycans and glycosaminoglycans research
- Magnesium in Health and Disease
- Hepatitis C virus research
- Hypertrophic osteoarthropathy and related conditions
- Autoimmune Bullous Skin Diseases
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Tsinghua University
2013-2022
Academy of Medical Sciences
2022
Academia Sinica
2022
Beijing Tsinghua Chang Gung Hospital
2022
Beijing Institute of Technology
2017
University of Pittsburgh
2013-2016
Wuhan Institute of Technology
2016
Institut de Recherche Vaccinale
2014-2015
<h3>Importance</h3> The aging of the population is associated with an increasing burden fractures worldwide. However, epidemiological features in mainland China are not well known. <h3>Objective</h3> To assess prevalence and factors osteoporosis, clinical fractures, vertebral adult 40 years or older China. <h3>Design, Setting. Participants</h3> This cross-sectional study, Osteoporosis Prevalence Study, was conducted from December 2017 to August 2018. A random sample individuals aged 20 who...
Rationale: Microbiome studies typically focus on bacteria, but fungal species are common in many body sites and can have profound effects the host. Wide gaps exist understanding of microbiome (mycobiome) its relationship to lung disease.Objectives: To characterize mycobiome at different respiratory tract levels persons with without HIV infection HIV-infected individuals chronic obstructive pulmonary disease (COPD).Methods: Oral washes (OW), induced sputa (IS), bronchoalveolar lavages (BAL)...
ABSTRACT Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome. It curable by excision of the causative tumor. However, few cases may persist or relapse after tumor resection. We aimed to investigate rate these events and related factors. retrospectively studied TIO patients treated with surgery in tertiary hospital. was established based on pathologic examination reversion hypophosphatemia. Refractory consisted those nonremission recurrent hypophosphatemia surgery. A total 230...
Resistance following antiviral therapy is commonly observed in human influenza viruses. Although this evolutionary process initiated within individual hosts, little known about the pattern, dynamics, and drivers of resistance at scale, including role played by reassortment. In addition, short duration virus infections limits available time window which to examine intrahost evolution. Using single-molecule sequencing, we mapped, detail, mutational spectrum an H3N2 A population sampled from...
Longitudinal studies of the lung microbiome are challenging due to invasive nature sample collection. In addition, in human disease usually performed after onset, limiting ability determine early events lung. We used a non-human primate model assess alterations over time response an HIV-like immunosuppression and determined impact on development obstructive disease. Cynomolgous macaques were infected with SIV-HIV chimeric virus SHIV89.6P. Bronchoalveolar lavage fluid samples collected...
Abstract Context Phosphate homeostasis was compromised in tumor-induced osteomalacia (TIO) due to increased fibroblast growth factor 23 (FGF23) secretion. Nevertheless, the glucose metabolic profile TIO patients has not been investigated. Objectives This work aimed clarify profiles and explore their interaction with impaired phosphate homeostasis. Methods 20 patients, individuals normal tolerance, type 2 diabetes mellitus (DM) were enrolled underwent an oral tolerance test (OGTT). Serum...
Abstract Context Osteopetrosis (OPT) is a rare skeletal disease characterized by high bone mass that has two major inheritance patterns: autosomal dominant osteopetrosis (ADO) and recessive (ARO). However, comprehensive descriptions of microarchitecture in OPT patients are limited. Objectives The aim this study was to comprehensively investigate the patients, explore age-related alterations describe heterogeneity among different genotypes. Methods Nine including 7 ADO with CLCN7 mutations, 1...
Despite the fact that China amounts to one-fifth of world's population, has a higher proportion elderly, and prevalence osteoporosis fracture, limited studies have investigated association between dietary patterns bone mineral density (BMD) as well fracture risk among elderly Chinese population. We aimed investigate different BMD fractures, this may vary women men.
Abstract Context Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) tumor. After successful tumor resection, patients can recover from hypophosphatemia quicky. However, data on the changes in bone mineral density (BMD) and microstructure short term after surgery remained unclear. Objective This work aimed to investigate postoperative BMD both peripheral axial TIO patients. Methods We evaluated...
A novel mononegavirus was isolated in 1975 from ticks ( Ornithodoros coriaceus ) collected during investigation of an outbreak epizootic bovine abortion (EBA) northern California. It originally designated “bovine abortion-tick virus” (BA-T virus). The EBA is now known to be associated with a deltaproteobacterium infection, and not virus. BA-T virus had remained uncharacterized until now. We have determined by electron microscopy, serology, genome sequencing that the fourth member newly...
The Bunyaviridae family is made up of a diverse range viruses, some which cause disease and are for concern in human veterinary health. Here, we report the genomic antigenic characterization five previously uncharacterized bunyaviruses. Based on their ultrastructure, relationships phylogenomic relationships, viruses classified as members Orthobunyavirus genus. Three California encephalitis virus serogroup related to Trivittatus virus; two others most similar Mermet Simbu serogroup, Tataguine...
Abstract Context Hereditary distal renal tubular acidosis caused by SLC4A1 gene mutation (SLC4A1-dRTA) is a rare hereditary form of acidosis. Rickets or osteomalacia common complication SLC4A1-dRTA and seriously affects patients’ daily lives. However, studies on the bone microstructure in are limited. Objective This work aimed to evaluate patients, compared age- sex-matched healthy controls X-linked hypophosphatemic rickets (XLH) patients. Methods was retrospective study 11 Clinical...
Abstract Context X-linked hypophosphatemia (XLH) is the most common form of heritable hypophosphatemic rickets. Previous studies have found deteriorated bone microarchitecture in adults with XLH. Detailed on skeletal adolescent and pediatric patients XLH are still lacking. Objective This study aimed to evaluate geometry, density, microarchitecture, stiffness by using high-resolution peripheral quantitative computed tomography (HR-pQCT). Method utilized HR-pQCT assess 106 Chinese Result...
Current prevalence and genotype distribution of hepatitis C virus (HCV) infection remain unknown in Ningxia, northwest China. From June to December 2013, 13,022 individuals were screened Ningxia HIV/AIDS Sentinel Surveillance System, with their demographic features collected serum samples tested for HCV antibody. Sero-positive drug users further subjected sequencing NS5B Core regions HCV. The anti-HCV was 0.34 % among without history use, while it 15.80 users. Of 79 sequences amplified from...
Abstract Context Nearly 20% patients with tumor-induced osteomalacia (TIO) experienced recurrence or nonrecovery after surgery. Serum fibroblast growth factor 23 and phosphate concentrations are not sufficient for prognosis in such cases. Despite its importance understanding of underlying pathogenesis, the alteration systemic metabolism refractory TIO remains unclear. Objective We aimed to find metabolomic characteristics establish a novel predictive model early discriminating based on their...