A5011158028- Aluminum Alloys Composites Properties
- Magnesium Alloys: Properties and Applications
- Aluminum Alloy Microstructure Properties
- Chronic Myeloid Leukemia Treatments
- Drilling and Well Engineering
- Ion channel regulation and function
- Curcumin's Biomedical Applications
- Oil and Gas Production Techniques
- Microstructure and mechanical properties
- Advanced Welding Techniques Analysis
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Neuroscience and Neural Engineering
- Microtubule and mitosis dynamics
- Tunneling and Rock Mechanics
- RNA Interference and Gene Delivery
- Geotechnical and Geomechanical Engineering
- Erosion and Abrasive Machining
- Titanium Alloys Microstructure and Properties
- Fluid Dynamics and Turbulent Flows
- Hydraulic Fracturing and Reservoir Analysis
- Acute Myeloid Leukemia Research
- Advanced ceramic materials synthesis
- Microgrid Control and Optimization
- Chronic Lymphocytic Leukemia Research
Guangdong Pharmaceutical University
2009-2024
Chongqing University
2021-2024
Weifang University
2008-2022
Beijing Institute of Technology
2022
Key Laboratory of Guangdong Province
2021
Nanchang University
2019-2020
Ruian People's Hospital
2018
Southern Medical University
2013
University of Jinan
2012-2013
Guangdong Medical College
2010
Based on the fact that hydrogen sulfide (H2S) possesses smallest steric hindrance among thiols and SH− group adds faster to an electron-poor CC double bond, we designed synthesized a tricyanoethylene-derived colorimetric chemodosimeter 1 for fast highly selective assay of H2S. Chemodosimeter exhibited excellent water-solubility due introduction two hydrophilic hydroxyl groups. Upon addition Na2S, showed (complete within 400 s) robust decrease absorption intensity (>97%), accompanied by color...
In this study, we showed that curcumin treatment resulted in activation of Chk1‐mediated G2 checkpoint, which was associated with the induction G2/M arrest and resistance cancer cells to curcumin‐induced apoptosis. Further investigation revealed inhibition Chk1 significantly abrogated sensitized curcumin‐resistant apoptosis via upregulation Bad turn loss mitochondrial membrane potential. These results indicate may serve as a mechanism for represents potential target reversal resistance. Our...
In the ongoing battle against BCR-ABL+ leukemia, despite significant advances with tyrosine kinase inhibitors (TKIs), persistent challenges of drug resistance and enduring presence leukemic stem cells (LSCs) remain formidable barriers to achieving a cure. this study, we demonstrated that Disulfiram (DSF) induces ferroptosis synergize TKIs in inhibiting cells, particularly targeting resistant LSCs, using cell models, mouse primary from patients. We elucidated mechanism by which DSF promotes...
ClC-3, a gene encoding candidate protein for volume-activated chloride (C(-)) channels, may be involved in tumor development. Herein we report study using an antisense "knock-down" strategy to investigate the mechanism by which ClC-3 affects cell proliferation nasopharyngeal carcinoma CNE-2Z cells. With immunoblots and MTT assays demonstrated that expression of was cycle dependent similar concentration-dependent manner, oligonucleotide specific inhibited proliferation. The level correlated...
// Bin Xu 1,4,* , Xiaobao Jin 1,2,* Ling Min 5,* Qin Li 1,2 Lulu Deng 1,6 Hui Wu 2 Guixian Lin Lixin Chen 3 Haifeng Zhang Chunmei Liwei Wang Jiayong Zhu Weizhang Fujiang Chu Juan Shen 1,4 Hongzhi and Jianwen Mao 1 Guangdong Key Laboratory for Bioactive Drugs Research, Pharmaceutical University, Guangzhou, China School of Basic Medicine, Department Pharmacology Physiology, Medical College, Jinan 4 Biosciences Biopharmaceutics, 5 Cancer Center Guangzhou 6 Pharmacology, * These authors...
To address the shortcomings of existing linear power flow calculation methods for distribution networks with low versatility and accuracy, a method considering distributed generation (DG) is proposed. According to characteristics using Taylor series expansion technology, nonlinear terms basic equation are linearized. The reactive generated by non-PV type DG simplified quadratic function voltage amplitude. Then, combined approximation model, into form. Based on equation, proposed method,...
Ultrafine-grained (UFG) materials typically exhibit high strength but disappointingly low ductility due to the limited dislocation accumulation. To evade strength-ductility tradeoff of UFG pure aluminum (Al), four kinds UFG/coarse-grained (CG)/UFG sandwich-structured Al laminates were designed via extrusion and cold rolling. Microstructure characterization displayed that grain size CG in always remained ∼5 times UFG, indicating significant heterogeneity between constituent layers. The finite...
Stretch-activated chloride currents (I(Cl,SA) ) have been considered to be a component of volume-activated (I(Cl,vol) for some time. This is due similarity in biophysical and pharmacological properties that involve membrane curvature-induced mechanism rearrangement the cytoskeleton induced by cell swelling or stretch. In present study, we demonstrated current density, along with time taken from activation peak, were significantly different between two currents, highly metastatic human...
Three types of laminates were designed by alternately stacking AZ91 extruded sheets in different states for extrusion to improve the mechanical properties. The tensile tests revealed that combination solid-solution-treated with aging-treated achieved high strength and ductility, i.e., ultimate ~386 MPa elongation ~19.8%, respectively. Electron backscatter diffraction (EBSD) TEM results indicated layers more nano-sized precipitates small grain size provided reasonable while low dislocation...
Glioblastoma (GBM) is the most common, aggressive, and chemorefractory primary brain tumor in adults. Identifying novel drug targets crucial for GBM treatment. Here, we demonstrate that tubulin alpha 1a (TUBA1A) significantly upregulated compared to low-grade gliomas (LGG) normal tissues. High TUBA1A expression associated with poor survival patients. knockdown results mitotic arrest reduces growth mice. interacts polo-like kinase 3 (PLK3) cytoplasm inhibit its activation. This interaction...