A5101776749- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Liver physiology and pathology
- Genetic and Kidney Cyst Diseases
- Tuberous Sclerosis Complex Research
- Renal cell carcinoma treatment
- Immune cells in cancer
- Lipid metabolism and disorders
- Venous Thromboembolism Diagnosis and Management
- Abdominal Trauma and Injuries
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- MRI in cancer diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Electrolyte and hormonal disorders
- Animal Nutrition and Physiology
- Trace Elements in Health
- Iron Metabolism and Disorders
- Ziziphus Jujuba Studies and Applications
- Extracellular vesicles in disease
First Affiliated Hospital of Zhengzhou University
2014-2024
Affiliated Hospital of Chengde Medical College
2023
Zhengzhou University
2015-2022
Henan Agricultural University
2011
tumor-infiltrating immune cells are highly relevant to the progression and prognosis of colorectal cancer (CRC). The aim this study is explore immune-related gene expression in tumor microenvironment CRC.CIBERSORT, a deconvolution algorithm, was used analyze infiltration 22 cell types 404 CRC 40 adjacent non-tumorous tissues.a wide heterogeneity among different paired tissues stages uncovered. M0 macrophages, M1 macrophages CD4 memory activated T were infiltrated significantly more compared...
It is crucial to grasp the characteristics of tumour immune microenvironment improve effects immunotherapy. In this study, and stromal scores 371 cases were calculated for quantitative analysis cell infiltration in hepatocellular carcinoma (HCC). The weighted gene co-expression network protein-protein interaction analysed identify microenvironment-related genes. results showed that patients with high had a higher 4-year recurrence-free rate. TP53, CTNNB1, AXIN1 mutations significantly varied...
Background: Liver cirrhosis is a major global health burden worldwide due to its high risk of morbidity and mortality. Role terlipressin for the management liver cirrhosis–related complications has been recognized during recent years. This article aims develop evidence-based clinical practice guidance on use complications. Methods: Hepatobiliary Study Group Chinese Society Gastroenterology Medical Association Hepatology Committee Research Hospital have invited gastroenterologists,...
Ferroptosis is one of the main mechanisms sorafenib against hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) plays an important role in heterogeneity, tumor metastasis, immunosuppressive microenvironment, and drug resistance HCC. However, there are few studies looking into relationship between ferroptosis EMT how they may affect prognosis HCC collectively.We downloaded gene expression clinical data patients from Cancer Genome Atlas (TCGA) International Consortium...
With the development of animal husbandry, shortage feedstuffs has become serious. Dietary fiber plays a crucial role in regulating health and production performance. The aim this study was to investigate effects three kinds corn straw-saccharification fibers (CSSF) such as high-fiber low-saccharification (HFLS), medium-fiber medium-saccharification (MFMS), low-fiber high-saccharification (LFHS) CSSF on reproductive performance sows. Thirty-two primiparous Yorkshire sows were randomly...
Hepatocellular carcinoma (HCC) is the main type of primary liver cancer and shows a heavy burden worldwide. Its recurrence mortality rate are still uncontrolled by usage present treatments. More attention has been focused on exploring specific genes that play important roles in HCC procession, function DEP domain containing 1B (DEPDC1B) not researched.
Primary hepatic neuroendocrine tumors (PHNETs), a group of neoplasms, are extremely rare. There only few case reports about PHNETs in the literature. The lack large samples and multicenter research results poor diagnostic therapeutic approaches.To discuss clinical characteristics, diagnosis, treatment risk factors related to survival.We retrospectively analyzed data, imaging features, immunohistochemistry efficacy 40 patients who were pathologically diagnosed with admitted First Affiliated...
Despite advances in immunosuppressive therapies, acute rejection response is still a serious concern especially the early phase after liver transplantation. This study aimed to evaluate whether blocking TSP1-CD47 signaling pathway could attenuate An allogeneic mouse orthotopic transplantation model (Balb/c→C3H) with prolonged cold ischemic was used induce severe IRI and lethal rejection. CD47mAb or isotype matched-control IgG2a administered donor during graft perfusion. Recipients were...
Congestive hepatopathy (CH) is a hepatic vascular disease that results in chronic liver congestion, which can lead to fibrosis. New uses of metformin have been discovered over the years. However, function congestive fibrosis not yet fully understood. This study aimed investigate effect on mouse model CH. Partial ligation inferior vena cava (pIVCL) was used establish congestion. Metformin (0.1%) added daily drinking water animals, and tissue studied after 6 weeks. Hepatic stellate cells...
Terlipressin has been shown to be effective in controlling variceal bleeding and decreasing associated mortality. is a synthetic analogue of vasopressin safer than arginine vasopressin; it induces selective vasoconstriction by stimulating the V1 receptors that are predominantly located splanchnic tissues. However, severe hyponatraemia may occur during terlipressin treatment, resulting neurological manifestations.We describe two patients who presented marked decrease serum sodium levels...
Iron (Fe) is an essential and important trace element for animals. In order to study its metabolism relationship with hepcidin, piglet models of Fe-deficiency Fe-overload were established by intramuscular injection different doses Fe-dextran (150 mg Fe/ml) within 1 week age. Twelve piglets divided into three groups four animals: deficiency, regular overload group, receiving 0 ml, ml 6 Fe-dextran, respectively. The euthanised at the age 7 days analysis. results showed that Fe-concentrations...
The comprehensive role of interleukin (IL) 18 during liver regeneration is barely studied. Our aim to evaluate the IL18 in after partial hepatectomy (PH) mice. expression profile and gut 70% PH was measured. Liver samples 85% from knockout (IL18 −/− ) mice wild type (WT) were collected for comparison regeneration. effect recombinant on tested mice, utility binding protein (BP) also evaluated following WT Expression levels elevated PH. weight/body weight ratios (LBWRs) significantly higher...
To explore the risk factors of short-term prognosis severe Budd-Chiari syndrome (BCS) patients,established and verified nomogram prediction model for these BCS patients evaluated its clinical application value.