A5109149440- MicroRNA in disease regulation
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Parasites and Host Interactions
- RNA and protein synthesis mechanisms
- Plant Virus Research Studies
- Circular RNAs in diseases
- Pregnancy-related medical research
- Global Health Workforce Issues
- RNA Research and Splicing
- Mosquito-borne diseases and control
- RNA Interference and Gene Delivery
- Global Maternal and Child Health
- Retinal Development and Disorders
- Extracellular vesicles in disease
Hubei Polytechnic University
2023-2025
Chinese Academy of Sciences
2011-2023
Wuhan Institute of Virology
2014-2023
Center for Excellence in Brain Science and Intelligence Technology
2017
Herpes simplex virus type 1 strain 129 (H129) has represented a promising anterograde neuronal circuit tracing tool, which complements the existing retrograde tracers. However, current H129 derived tracers are multisynaptic, neither bright enough to label details of neurons nor capable determining direct projection targets as monosynaptic tracer.Based on bacterial artificial chromosome H129, we have generated serial recombinant viruses for tracing. Among them, H129-G4 was obtained by...
Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects, primarily manifesting as neurological disorders. HCMV alters expression cellular microRNAs (miRs) and induces cell cycle arrest, which in turn modifies the environment to favor virus replication. Previous observations found that reduces miR-21 neural progenitor/stem cells (NPCs). Here, we show NPCs U-251MG represses while increasing levels Cdc25a, regulator known target miR-21. These opposing responses...
Background Human cytomegalovirus (HCMV) encodes microRNAs (miRNAs) that function as post-transcriptional regulators of gene expression during lytic infection in permissive cells. Some miRNAs have been shown to suppress virus replication, which could help HCMV establish or maintain latent infection. However, miRNA has not comprehensively examined and compared using cell culture systems representing (lytic) semi-permissive vs. non-permissive (latent-like) Methods Viral levels kinetics were...
Schistosomiasis is a neglected tropical disease that causes significant global burden. The aim of this study was to report the latest estimates global, regional, and national schistosomiasis burden forecast changes in schistosomiasis-related This work based on 2021 Global Burden Disease (GBD) study. We analyzed data by sex, age years, Socio-Demographic Index (SDI) region country, using Age-Standardized Rates (ASR) for comparisons among different groups. Estimated Annual Percent Changes...
ABSTRACT Human cytomegalovirus (HCMV) infection of the developing fetus frequently results in major neural developmental damage. In previous studies, HCMV was shown to downregulate progenitor/stem cell (NPC) markers and induce abnormal differentiation. As Notch signaling plays a vital role maintenance stem status is switch that governs NPC differentiation, effect on pathway NPCs investigated. downregulated mRNA levels Notch1 its ligand, Jag1, reduced protein altered intracellular...
Although a varicella-zoster virus (VZV) vaccine has been used for many years, the neuropathy caused by VZV infection is still major health concern. Open reading frame 7 (ORF7) of recognized as neurotropic gene in vivo, but its neurovirulent role remains unclear. In present study, we investigated effect ORF7 deletion on replication cycle at entry, genome replication, expression, capsid assembly and cytoplasmic envelopment, transcellular transmission differentiated neural progenitor cells...
Human cytomegalovirus (HCMV) is the leading infectious cause of birth defects, and may lead to severe or lethal diseases in immunocompromised individuals. Several HCMV strains have been identified widely applied research, but no isolate from China has characterized. In present study, we isolated, characterized sequenced first Chinese clinical strain Han, constructed novel functional clone Han-BAC-2311. Han was isolated urine sample a infant with multiple developmental disorders. It expresses...
Abstract Human cytomegalovirus (HCMV) preferentially targets neural progenitor cells (NPCs) in congenitally infected fetal brains, inducing neurodevelopmental disorders. While HCMV expresses several microRNAs (miRNAs) during infection, their roles NPC infection are unclear. Here, we characterized expression of cellular and viral miRNAs HCMV‐infected NPCs early by microarray identified seven differentially expressed six significantly upregulated miRNAs. Deep learning approaches were used to...